The X-ray luminosity function of galaxies in the Coma cluster

The XMM-Newton survey of the Coma cluster of galaxies covers an area of 1.86 square degrees with a mosaic of 16 pointings and has a total useful integration time of 400 ksec. Detected X-ray sources with extent less than 10" were correlated with cataloged galaxies in the Coma cluster region. The redshift information, which is abundant in this region of the sky, allowed us to separate cluster members from background and foreground galaxies. For the background sources, we recover a typical LogN-LogS in the flux range 1.e-15 - 1.e-13 ergs/s/cm^2 in the 0.5-2.0 keV band. The X-ray emission from the cluster galaxies exhibits X-ray colors typical of thermal emission. The luminosities of Coma galaxies lie in the 1.e39-1.e41 ergs/s interval in the 0.5-2.0 keV band. The luminosity function of Coma galaxies reveals that their X-ray activity is suppressed with respect to the field by a factor of 5.6, indicating a lower level of X-ray emission for a given stellar mass.Comment: 16 pages, 2004 A&A in pres

Antiagregación y anticoagulación en síndromes coronarios agudos: niveles de evidencia

Management of acute coronary syndromes (ACS) has moved rapidly in parallel with our understanding of the pathophysiological basis of the disease. In the eighties, the demonstration of the pivotal role of coronary thrombosis in the etiology of a ACS led to administration of aspirin and unfractionated heparin. In recent years, new medical and invasive therapies have been developed: anti-platelets (thienopyridines and glycoprotein Ilb/IlIa inhibitors), antithrombins (low molecularweight heparins) and most recently, factor Xa inhibitors (pentasaccharides). As new treatments are rapidly added, clinicians are constantly challenged to incorporate new information and guidelines into their practices in a timely fashion

Tratamiento del síndrome antifosfolípido

The antiphospholipid syndrome (APS) is a disorder of recurrent thrombosis and/or pregnancy loss associated with the presence of antiphospholipid antibodies and persistently positive lupus anticoagulant, anticardiolipin or anti beta2-glycoprotein1. Oral anticoagulants are the best available and most effective treatment for the secondary prevention of recurrent venous or arterial thrombosis. Patients with APS are treated with long-term therapy to prolong the INR to 2.0-3.0. Low-molecular-weight heparin in combination with low-aspirin dose is a reasonable strategy to avoid pregnancy loss in women with this syndrome

Star Forming Objects in the Tidal Tails of Compact Groups

A search for star forming objects belonging to tidal tails has been carried out in a sample of deep Halpha images of 16 compact groups of galaxies. A total of 36 objects with Halpha luminosity larger than 10^38 erg s-1 have been detected in five groups. The fraction of the total Halpha luminosity of their respective parent galaxies shown by the tidal objects is always below 5% except for the tidal features of HCG95, whose Halpha luminosity amounts to 65% of the total luminosity. Out of this 36 objects, 9 star forming tidal dwarf galaxy candidates have been finally identified on the basis of their projected distances to the nuclei of the parent galaxies and their total Halpha luminosities. Overall, the observed properties of the candidates resemble those previously reported for the so-called tidal dwarf galaxies.Comment: 5 gif figures. Accepted for publication in Astrophysical Journa

Diagnóstico y tratamiento de la trombosis venosa profunda

Deep-vein thrombosis (DVT) is a common condition that can lead to complications such as postphlebitic syndrome, pulmonary embolism and death. Currently, an algorithm strategy combining pretest probability, D-dimer testing and compression ultrasonography imaging allows for safe and convenient estimation of suspected lower-limb thrombosis. The mainstay of treatment is anticoagulation therapy. The use of low-molecular-weight heparin or pentasaccharide (fondaparinux) allows for outpatient management of most patients with DVT. The duration of anticoagulation depends on whether the primary event was idiopathic or secondary to a transient risk factor. Interventions such as thrombolysis and placement of inferior vena cava filter are reserved for special situations

Fibrinogen Sevilla, a congenital dysfibrinogenemia characterized by an abnormal monomer aggregation and a defective plasmin lysis

A dysfibrinogenemia (fibrinogen Sevilla) was detected in a 64-yr-old woman with no previous history of hemorrhagic diathesis or thrombosis. Thrombin and reptilase times were prolonged. The aggregation of fibrin monomers showed a prolonged latency time with a defective slope although fibrinopeptide release and clot stabilization were found to be normal. Plasmin proteolysis was abnormal with a much slower plasmic degradation in patient's purified fibrinogen. By chromatofocussing the patient's fibrinogen showed an abnormality in pattern elution with a second peak eluting at a pH slightly more basic than the normal one (pH 5.5). Likewise, the isoelectrofocussing of purified non-reduced patient's fibrinogen in agarose gel showed an abnormal distribution in its focussed bands, especially in a group which focussed in a pI-interval between 5.20-5.85. By two-dimensional electrophoresis we did not find any abnormality in the fibrinogen-reduced chains. These results could indicate that the abnormal monomer aggregation, as well as the defective plasmin lysis, could be due to conformational aspects of fibrinogen rather than to structural defects

Seismic structure of the southern Gulf of California from Los Cabos block to the East Pacific Rise

Multichannel reflection and coincident wide-angle seismic data collected during the 2002 Premier Experiment, Sea of Cortez, Addressing the Development of Oblique Rifting (PESCADOR) experiment provide the most detailed seismic structure to date of the southern Gulf of California. Multichannel seismic (MCS) data were recorded with a 6-km-long streamer, 480-channel, aboard the R/V Maurice Ewing, and wide-angle data was recorded by 19 instruments spaced every similar to 12 km along the transect. The MCS and wide-angle data reveal the seismic structure across the continent-ocean transition of the rifted margin. Typical continental and oceanic crust are separated by a similar to 75-km-wide zone of extended continental crust dominated by block-faulted basement. Little lateral variation in crustal thicknesses and seismic velocities is observed in the oceanic crust, suggesting a constant rate of magmatic productivity since seafloor spreading began. Oceanic crustal thickness and mean crustal velocities suggest normal mantle temperature (1300 degrees C) and passive mantle upwelling at the early stages of seafloor spreading. The crustal thickness, width of extended continental crust, and predicted temperature conditions all indicate a narrow rift mode of extension. On the basis of upper and lower crust stretching factors, an excess of lower crust was found in the extended continental crust. Total extension along transect 5W is estimated to be similar to 35 km. Following crustal extension, new oceanic crust similar to 6.4-km-thick was formed at a rate of similar to 48 mm a(-1) to accommodate plate separation

The GALEX UV luminosity function of the cluster of galaxies Abell 1367

We present the GALEX NUV (2310 A) and FUV (1530 A) galaxy luminosity functions of the nearby cluster of galaxies A1367 in the magnitude range -20.3< M_AB < -13.3. The luminosity functions are consistent with previous (~ 2 mag shallower) estimates based on the FOCA and FAUST experiments, but display a steeper faint-end slope than the GALEX luminosity function for local field galaxies. Using spectro-photometric optical data we select out star-forming systems from quiescent galaxies and study their separate contributions to the cluster luminosity function. We find that the UV luminosity function of cluster star-forming galaxies is consistent with the field. The difference between the cluster and field LF is entirely due to the contribution at low luminosities (M_AB >-16 mag) of non star-forming, early-type galaxies that are significantly over dense in clusters.Comment: 4 pages, 4 figures, 1 table. Accepted for publication in Astrophysical Journal Letter

Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice

Anti-angiogenic therapy reduces both plaque growth and intimal neovascularization in apolipoprotein-E-deficient mice (apoE-/-). Vascular endothelial growth factor (VEGF) has been suggested as playing a role in the development of atherosclerosis. We examined the hypothesis that VEGF and VEGF receptor-2 (VEGFR-2) expression is upregulated in apoE-/- and, since it could be driven by oxidative stress, tested whether dietary supplementation with vitamins C and E could downregulate it.Two-month-old apoE-/- received vitamin C combined with alpha- or beta-tocopherol for 4 weeks. Aortic VEGF and VEGFR-2 expression were measured by RT-qPCR and western blot.ApoE-/- showed significantly higher expression of aortic VEGF and VEGFR-2 mRNA (P<0.001) and protein (P<0.001) than wild-type mice, as well as increased plasma VEGF (P<0.001). Vitamin C and alpha-tocopherol significantly reduced aortic VEGF and VEGFR-2 expression in apoE-/- (P<0.001), circulating VEGF (P<0.01) and plasma lipid peroxidation (P<0.01). apoE-/- receiving vitamin C and beta-tocopherol showed diminished lipid peroxidation and VEGFR-2, but only partial reduction of VEGF expression. These data demonstrate that augmented VEGF and VEGFR-2 expression in apoE-/- vasculature can be downregulated by vitamins C and E, at least partially through oxidative stress reduction. This novel mechanism could contribute to explaining the beneficial effects of antioxidant vitamins in experimental atherosclerosis