General Treatment of Reflection of Spherical Electromagnetic Waves from a Spherical Surface and its Implications for the ANITA Anomalous Polarity Events

We develop a general formalism to treat reflection of spherical electromagnetic waves from a spherical surface. Our main objective is interpretation of radio wave signals produced by cosmic ray interactions with Earth's atmosphere which are observed by the Antarctica based ANITA detector after reflection off the ice surface. The incident wave is decomposed into plane waves and each plane wave is reflected off the surface using the standard Fresnel formalism. For each plane wave the reflected wave is assumed to be locally a plane wave. This is a very reasonable assumption and there are no uncontrolled approximations in our treatment of the reflection phenomenon. The surface roughness effects are also included by using a simple model. We apply our formalism to the radiation produced by the balloon-borne HiCal radio-frequency (RF) transmitter. Our final results for the reflected power are found to be in good agreement with data for all elevation angles. We also study the properties of reflected radio pulses in order to study their phase relationship with direct pulses. We find that for some roughness models the pulse shape can be somewhat distorted and may be misidentified as a direct pulse. However this is a rather small effect and is unable to provide an explanation for the observed mystery events by ANITA.Comment: 26 pages, 7 figures, substantial revision

Sinteza izoamilnog acetata pomoću lipaze u sustavu bez otapala s vinilnim acetatom kao donorom acila

Synthesis of isoamyl acetate, a flavour ester extensively used in food industry, has been carried out in a solvent-free system. In the present study, an attempt has been made to enhance the isoamyl acetate synthesis yield by transesterification of isoamyl alcohol with vinyl acetate using immobilized Rhizopus oryzae NRRL 3562 lipase. In the present synthesis, substrates had no inhibitory effect on immobilized lipase. The effects of various reaction parameters on isoamyl acetate synthesis were studied and maximum conversion was achieved at 16 % (by mass per volume) of immobilized lipase, 40 °C and 200 rpm. Under these conditions, 8-hour reaction time was sufficient to reach a high ester conversion of 95 % with 0.5 mol/L of isoamyl alcohol. The structure of the transesterified product was confirmed by infrared and nuclear magnetic resonance spectroscopic studies. Immobilized lipase had Km and vmax values of 306.53 mmol/L and 99 µmol/(h·g) respectively, for isoamyl acetate synthesis in a solvent-free system.Provedena je sinteza izoamilnog acetata, estera koji se često koristi kao pojačivač okusa u prehrambenoj industriji, u sustavu bez otapala. Pokušao se poboljšati prinos izoamilnog acetata transesterifikacijom s vinilnim acetatom pomoću imobilizirane lipaze izolirane iz soja Rhizopus oryzae NRRL 3562. Pri tome supstrat nije inhibirao imobiliziranu lipazu. Istražen je utjecaj različitih parametara reakcije na sintezu te ustanovljeno da je maksimalna pretvorba postignuta sa 16 % (m/V) imobilizirane lipaze pri 40 °C i 200 rpm. Pri tim je uvjetima nakon 8 sati postignuta 95 %-tna konverzija s 0,5 mol/L izoamilnog acetata. Struktura produkta utvrđena je infracrvenom spektroskopijom i nuklearnom magnetskom rezonancijom. Imobilizirana lipaza imala je Km vrijednost od 306,53 mmol/L i υmax od 99 µmol/(h∙g)

The power of narrative persuasion: how an entertainment-education serial drama tackled open defecation and promoted contraceptive use in India

Television and radio serial dramas have been used as an effective entertainment-education (EE) strategy to address complex health and social issues around the world. In this article, we analyse India’s experience with the EE television serial, Main Kuch Bhi Kar Sakti HoonSeason 3 (I, A Woman, Can Achieve Anything, hereafter MKBKSH-3), broadcasted in 2019. Produced by Population Foundation of India, MKBKSH-3purposely employed principles of narrative persuasion to tackle open defecation, promote contraceptive use, and advocate for gender equality in a deeply entrenched patriarchal system. As part of a larger programme evaluation, we conducted data collection using two complementary methods: (1) field experiments in Uttar Pradesh’s Kanpur Dehat district with repeated measures among viewers and non-viewers; and (2) viewer surveys through the popular interactive voice response system with callers from across 28 states and union territories. Wherever possible, we kept questions consistent to help triangulate research findings. Our results indicate a significant increase in toilet ownership and decrease in open defecation among MKBKSH-3viewers. Further, MKBKSH-3’scharacters and storylines helped raise awareness of injectable contraceptives, and viewers—both male and female—displayed an increased likelihood of moving toward adopting contraceptives that were promoted. These empirical findings add to the growing literature on the value of entertainment-education serial dramas as enabling media for social and behaviour change.publishedVersio

Anisotropic AGN Outflows and Enrichment of the Intergalactic Medium

We investigate the cosmological-scale influence of outflows driven by AGNs on metal enrichment of the intergalactic medium. AGNs are located in dense cosmological structures which tend to be anisotropic. We designed a semi-analytical model for anisotropic AGN outflows which expand away along the direction of least resistance. This model was implemented into a cosmological numerical simulation algorithm for simulating the growth of large-scale structure in the universe. Using this modified algorithm, we perform a series of 9 simulations inside cosmological volumes of size $(128 h^{-1}{\rm Mpc})^3$, in a concordance $\Lambda$CDM universe, varying the opening angle of the outflows, the lifetimes of the AGNs, their kinetic fractions, and their level of clustering. For each simulation, we compute the volume fraction of the IGM enriched in metals by the outflows. The resulting enriched volume fractions are relatively small at $z \gtrsim 2.5$, and then grow rapidly afterward up to $z = 0$. We find that AGN outflows enrich from 65% to 100% of the entire universe at the present epoch, for different values of the model parameters. The enriched volume fraction depends weakly on the opening angle of the outflows. However, increasingly anisotropic outflows preferentially enrich underdense regions, a trend found more prominent at higher redshifts and decreasing at lower redshifts. The enriched volume fraction increases with increasing kinetic fraction and decreasing AGN lifetime and level of clustering.Comment: 19 pages, 16 figures, submitted. The version uploaded here does not contain Figs 5, 6 & 7, because of their large sizes. Those can be found along with the full paper at: http://www.astro.phy.ulaval.ca/staff/paramita/AllPages/Talks-Posters/Papers_Thesis/ms_AGNoutflow.pd

Geographical Variations in Prostate Cancer Outcomes: A Systematic Review of International Evidence

Background: Previous reviews of geographical disparities in the prostate cancer continuum from diagnosis to mortality have identified a consistent pattern of poorer outcomes with increasing residential disadvantage and for rural residents. However, there are no contemporary, systematic reviews summarizing the latest available evidence. Our objective was to systematically review the published international evidence for geographical variations in prostate cancer indicators by residential rurality and disadvantage.Methods: Systematic searches of peer-reviewed articles in English published from 1/1/1998 to 30/06/2018 using PubMed, EMBASE, CINAHL, and Informit databases. Inclusion criteria were: population was adult prostate cancer patients; outcome measure was PSA testing, prostate cancer incidence, stage at diagnosis, access to and use of services, survival, and prostate cancer mortality with quantitative results by residential rurality and/or disadvantage. Studies were critically appraised using a modified Newcastle-Ottawa Scale.Results: Overall 169 studies met the inclusion criteria. Around 50% were assessed as high quality and 50% moderate. Men from disadvantaged areas had consistently lower prostate-specific antigen (PSA) testing and prostate cancer incidence, poorer survival, more advanced disease and a trend toward higher mortality. Although less consistent, predominant patterns by rurality were lower PSA testing, prostate cancer incidence and survival, but higher stage disease and mortality among rural men. Both geographical measures were associated with variations in access and use of prostate cancer-related services for low to high risk disease.Conclusions: This review found substantial evidence that prostate cancer indicators varied by residential location across diverse populations and geographies. While wide variations in study design limited comparisons across studies, our review indicated that internationally, men living in disadvantaged areas, and to a lesser extent more rural areas, face a greater prostate cancer burden. This review highlights the need for a better understanding of the complex social, environmental, and behavioral reasons for these variations, recognizing that, while important, geographical access is not the only issue. Implementing research strategies to help identify these processes and to better understand the central role of disadvantage to variations in health outcome are crucial to inform the development of evidence-based targeted interventions

Novel Role of Phosphorylation-Dependent Interaction between FtsZ and FipA in Mycobacterial Cell Division

The bacterial divisome is a multiprotein complex. Specific protein-protein interactions specify whether cell division occurs optimally, or whether division is arrested. Little is known about these protein-protein interactions and their regulation in mycobacteria. We have investigated the interrelationship between the products of the Mycobacterium tuberculosis gene cluster Rv0014c-Rv0019c, namely PknA (encoded by Rv0014c) and FtsZ-interacting protein A, FipA (encoded by Rv0019c) and the products of the division cell wall (dcw) cluster, namely FtsZ and FtsQ. M. smegmatis strains depleted in components of the two gene clusters have been complemented with orthologs of the respective genes of M. tuberculosis. Here we identify FipA as an interacting partner of FtsZ and FtsQ and establish that PknA-dependent phosphorylation of FipA on T77 and FtsZ on T343 is required for cell division under oxidative stress. A fipA knockout strain of M. smegmatis is less capable of withstanding oxidative stress than the wild type and showed elongation of cells due to a defect in septum formation. Localization of FtsQ, FtsZ and FipA at mid-cell was also compromised. Growth and survival defects under oxidative stress could be functionally complemented by fipA of M. tuberculosis but not its T77A mutant. Merodiploid strains of M. smegmatis expressing the FtsZ(T343A) showed inhibition of FtsZ-FipA interaction and Z ring formation under oxidative stress. Knockdown of FipA led to elongation of M. tuberculosis cells grown in macrophages and reduced intramacrophage growth. These data reveal a novel role of phosphorylation-dependent protein-protein interactions involving FipA, in the sustenance of mycobacterial cell division under oxidative stress

Multilevel determinants of breast cancer survival: association with geographic remoteness and area-level socioeconomic disadvantage

A major priority for cancer control agencies is to reduce geographical inequalities in cancer outcomes. While the poorer breast cancer survival among socioeconomically disadvantaged women is well established, few studies have looked at the independent contribution that area- and individual-level factors make to breast cancer survival. Here we examine relationships between geographic remoteness, area-level socioeconomic disadvantage and breast cancer survival after adjustment for patients’ socio- demographic characteristics and stage at diagnosis. Multilevel logistic regression and Markov chain Monte Carlo simulation were used to analyze 18 568 breast cancer cases extracted from the Queensland Cancer Registry for women aged 30 to 70 years diagnosed between 1997 and 2006 from 478 Statistical Local Areas in Queensland, Australia. Independent of individual-level factors, area-level disadvantage was associated with breast-cancer survival (p=0.032). Compared to women in the least disadvantaged quintile (Quintile 5), women diagnosed while resident in one of the remaining four quintiles had significantly worse survival (OR 1.23, 1.27, 1.30, 1.37 for Quintiles 4, 3, 2 and 1 respectively).) Geographic remoteness was not related to lower survival after multivariable adjustment. There was no evidence that the impact of area-level disadvantage varied by geographic remoteness. At the individual level, Indigenous status, blue collar occupations and advanced disease were important predictors of poorer survival. A woman’s survival after a diagnosis of breast cancer depends on the socio-economic characteristics of the area where she lives, independently of her individual-level characteristics. It is crucial that the underlying reasons for these inequalities be identified to appropriately target policies, resources and effective intervention strategies

The impact of the TPP on selected ASEAN economies

Abstract The Trans Pacific Partnership was set to be the world's largest and most comprehensive FTA linking 12 countries on both sides of the Pacific. In a major turnaround, late January 2017, USA-one of the major trading partners to the region announced its decision to withdraw from it. Four of the ASEAN members under the TPP, namely Brunei, Malaysia, Singapore and Vietnam, have a number of existing FTAs with some major TPP members and hold a significant trade share with them. However, these countries do not have any agreements with Canada and Mexico and except Singapore, have no other trade negotiation with the USA, though the USA absorbs a significant share of the exports of the TPP-ASEAN nations, particularly of Vietnam. Given this background, withdrawal of the USA seems to be a major setback for the TPP-ASEAN countries as these economies are expected to be the largest beneficiaries of the agreement. This study investigates how far the non-participation of the USA would affect the overall growth and welfare of each of the TPP-ASEAN countries. For this purpose, the study separately evaluates the impact of the TPP on each of the TPP-ASEAN countries. As an analytical framework, the paper uses a global CGE model and attempts a number of simulations by calibrating various trade integration scenarios, such as tariff reduction and input-augmenting technological change. Results of the study show that all of the TPP-ASEAN members enjoy a welfare gain and positive growth in total output and trade when the USA is a member. Vietnam and Malaysia, in particular are the largest beneficiaries. When the USA is omitted, these countries continue to have positive growth rates but the rates fall considerably

Multiple primary cancers among colorectal cancer survivors in Queensland, Australia, 1996-2007

Purpose To quantify the demographic and clinical factors associated with an increased risk of multiple primary cancers (MPCs) among colorectal cancer survivors. Methods Standardized incidence ratios for MPCs were calculated for residents of Queensland, Australia, who were diagnosed with a first primary colorectal cancer between 1996 and 2005 and survived for at least 2 months. Relative risk ratios were calculated for all MPCs combined and selected individual sites using multivariate Poisson models. Results A total of 1,615 MPCs were observed among 15,755 study patients. The cohort had a significant excess risk of developing subsequent colorectal (SIR = 1.47, 95 % CI 1.30-1.66) or non-colorectal (SIR = 1.24, 95 % CI 1.18-1.31) cancers relative to the incidence of cancer in the general population. Age at initial diagnosis, follow-up time, initial colorectal subsite, and surgical treatment were independently associated (p < 0.01) with the overall risk of developing MPCs after adjustment. The relative risk ratio was 1.23 (95 % CI 1.07-1.41) for those aged 20-59 years compared with the 70-79 age group and 0.82 (95 % CI 0.72-0.92) for 1-5-year follow-up relative to the first year. The likelihood of being diagnosed with a MPC was 33 % higher (95 % CI 1.12-1.56) for surgically treated patients and 45 % higher (95 % CI 1.29-1.64) after proximal colon cancers relative to rectal cancer. Conclusions While these population-based results do not incorporate all possible risk factors, they form an important foundation from which to further investigate the etiological causes that result in the development of MPCs among colorectal cancer survivors.Full Tex