A conceptual integration approach to the property word nagy ‘big’

This paper describes the various readings of the typically size-related Hungarian adjective nagy ‘big’ in combination with the corresponding noun readings in a corpus-based analysis. Adjective-noun combinations have not only attracted the attention of psychologists (Murphy 2002; Smith et al. 1988; Wisniewski 1997), but they are also in the focus of cognitive linguistics. This study is carried out chiefly in terms of two conceptual models of adjectival modification: the conceptual integration model (Fauconnier 2004; Turner 2007), and the lexical semantic model (Paradis 2005; 2008). The analysis proposed here is applied to corpus data compiled from the Hungarian National Corpus (HNC). 1038 occurrences of nagy -noun constructions have been evaluated for the appropriate adjective versus noun readings with the contextual environment at hand. The results suggest that even though nagy is typically associated with size-interpretations (e.g., nagy ablak ‘big window’ or nagy fa ‘big tree’), other associations such as nagy öröm ‘great joy’, nagy esemény ‘important occasion’ are in fact more frequent. This finding is in accordance with recent studies proposing that linguistic frequency does not always cooccur with cognitive salience (Gilquin 2006)

A proteinkináz C izoenzimek vizsgálatának jelentősége a szisztémás lupus erythematosus-ban szenvedő betegek perifériás monocitáiban és limfocitáiban = The importance of the investigations on the protein kinase C isoenzymes in the monocytes and lymphocytes of patients with systemic lupus erythematosus

Új eredmények 1. A szisztémás lupus erythematosus (SLE) betegségben szenvedő betegek T limfocitáiban a protein kináz C (PKC) izoenzimek közül a béta, delta, az éta, az epszilon, a théta és a zéta, a monocitákban pedig a PKC delta, epszilon és zéta sejten belüli expressziója mind fehérje, mind hírvivő RNS szinten csökkent. Ez SLE specifikus jelenség, és a kimutatott defektus érvényesül ezen fehérjék géntranszkripciójának a szintjén. 2. A glükokortikoszteroid kezelés hatására ezek mennyisége - a T sejtekben található PKC théta kivételével -megemelkedik. 3. Az SLE-s betegek monocitáiban található csökkent arachidonsav termelés a PKC delta alulműködéséhez köthető, ami új szempontot jelent ezen sejtek SLE-ben megfigyelt kóros működésében. 4. Az SLE-s betegekben a CD4+ CD25+ Fox P3+ regulatórikus (szupresszor) T sejtek abszolut száma csökken a perifériás vérben, ami plazmaferezis hatására - a betegek javulásával együtt -megemelkedik. 5. HaCaT keratinocitákban kimutattuk, hogy a PKC alfa és PKC delta serkenti a differenciálódást és apoptózist, míg ezzel párhuzamban gátolja a proliferációt és tumor növekedést immundeficiens egerekben. Ezzel ellentétben a PKC béta és epszilon in vitro és in vivo is növeli a keratinociták sejtosztódását és gátolja a differenciálódást és az apoptózist. | NEW RESULTS 1. In the patients with systemic lupus erythematosus (SLE) the decreased expressions of some protein kinase C (PKC) isoenzymes can be observed at both protein and messanger RNA levels as follows, in the T cells, PKC beta, delta, eta, epsilon, theta, zeta; in the monocytes PKC delta, epsilon and zeta. This phenomenon is SLE specific, and it reflects the defects in the synthesis of these proteins at the level of gene transcription. 2. The amount of these isoenzymes can be increased by glucocorticosteroids, with the exception of PKC theta in the T cells. 3. The decreased production of arachidonic acid in the monocytes of SLE patients can be related to the inpairment of PKC delta what shows a new aspect of monocyte defects linked to this disease. 4. The absolute number of regulatory CD4+ CD25+ Fox P3+ (suppressor) T cells is decreased in the peripheral blood of SLE patients what can be increased by plasmapheresis, and what is parallel with the clinical imrpovement of the patients. 5. In HaCaT keratinocytes PKC alpha and PKC delta stimulates the differentiation and apoptosis whereas in immunodificient mice these isotypes of PKC inhibits the proliferation and tumor grouth. On the other hand, PKC beta and epsilon increases the proliferation of keratinocytes but inhibits their differentiation and apoptosis

Az asszertív magatartás jellemzői az ápolásban

The study deals with the theoritical questions of assertiveness. It describes the interpretations of the concept and the bases of the classification of assertive and nonassertive behaviour and the characteristics of each type. Furthermore, the results of the assertiveness research in nursing science are summarised with special regard to the possible causes of nurses’ non-assertiveness

Az asszertív magatartás jellemzői az ápolásban

The study deals with the theoritical questions of assertiveness. It describes the interpretations of the concept and the bases of the classification of assertive and nonassertive behaviour and the characteristics of each type. Furthermore, the results of the assertiveness research in nursing science are summarised with special regard to the possible causes of nurses’ non-assertiveness

Az ápolóhallgatók empátia és asszertivitás szintjének ellenőrzése

TesisLima NorteEscuela Académico Profesional de Negocios InternacionalesMarketing y Comercio InternacionalEsta investigación tuvo como objetivo principal determinar cómo ha evolucionado la producción de la uva peruana en el marco del tratado de Libre Comercio con EE.UU. 2003- 2017. Para el análisis de la investigación se tomó en cuenta los departamentos productores de uvas en el Perú, la cual se obtuvo datos con respecto a ellos del volumen de producción, área cosechada y rendimiento por hectárea. El diseño utilizado en esta investigación es no experimental puesto que no hubo manipulación de la variable, se utilizó datos ex post facto de fuentes confiables para los resultados como MINAGRI, SUNAT, FAOSTAT y Trade Map. De acuerdo a los resultados de la investigación se concluyó que la producción de la uva peruana en el marco del Tratado de Libre Comercio con EE.UU 2003-2017 ha tenido una tendencia creciente

Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer : The superiority of minimally invasive surgery

Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures.To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) in a network meta-analysis (NMA).We conducted a systematic search of the MEDLINE, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and CENTRAL databases to identify RCTs according to the following population, intervention, control, outcome (commonly known as PICO): P: Patients with resectable esophageal cancer; I/C: Transthoracic, transhiatal, minimally invasive (thoracolaparoscopic), hybrid, and robot-assisted esophagectomy; O: Survival, total adverse events, adverse events in subgroups, length of hospital stay, and blood loss. We used the Bayesian approach and the random effects model. We presented the geometry of the network, results with probabilistic statements, estimated intervention effects and their 95% confidence interval (CI), and the surface under the cumulative ranking curve to rank the interventions.We included 11 studies in our analysis. We found a significant difference in postoperative pulmonary infection, which favored the minimally invasive intervention compared to transthoracic surgery (risk ratio 0.49; 95%CI: 0.23 to 0.99). The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery (mean difference -85 min; 95%CI: -150 to -29), hybrid intervention (mean difference -98 min; 95%CI: -190 to -9.4), minimally invasive technique (mean difference -130 min; 95%CI: -210 to -50), and robot-assisted esophagectomy (mean difference -150 min; 95%CI: -240 to -53). Other comparisons did not yield significant differences.Based on our results, the implication of minimally invasive esophagectomy should be favored