THE NEED OF EDUCATION IN THE FIELD OF DOMESTIC VIOLENCE

The paper deals with the thesis that our classical type of education is not always enough to prepare us for the real life matters. One of those matters, a really negative one, is the domestic violence. It is a not very comfortable issue to talk about or to admit its existence in our lives. Furthermore, it deals with the possibility to find a place for this education issue in our educational system and its curriculums. The main aim is to prepare and to give the knowledge about the matter of domestic violence to the youngsters at a reasonable age. It could help in the field of prevention and even in the situations when we have to face the domestic violence – to identify its forms, what can the legal consequences be, how can we act, how can the legal authorities help, what are their competences and how or where can we get legal aid. The paper uses mainly analytical methods to examine the current state and comparative methods too, to compare the current state and the status recommended by the aim of the paper. The main research result is an educational model in the field of domestic violence which is practical and useful in real life situations.

Testing the method of multiple scales and the averaging principle for model parameter estimation of quasiperiodic two time-scale models

summary:Some dynamical systems are characterized by more than one time-scale, e.g. two well separated time-scales are typical for quasiperiodic systems. The aim of this paper is to show how singular perturbation methods based on the slow-fast decomposition can serve for an enhanced parameter estimation when the slowly changing features are rigorously treated. Although the ultimate goal is to reduce the standard error for the estimated parameters, here we test two methods for numerical approximations of the solution of associated forward problem: (i) the multiple time-scales method, and (ii) the method of averaging. On a case study, being an under-damped harmonic oscillator containing two state variables and two parameters, the method of averaging gives well (theoretically predicted) results, while the use of multiple time-scales method is not suitable for our purposes

The latitudinal uniformity of the unique life history of Velia caprai (Heteroptera: Veliidae) and notes to the pre-overwintering period of selected water striders (Heteroptera: Gerridae)

Temperate water striders (Gerridae) overwinter as adults and die after spring reproduction. European water cricket Velia caprai (Veliidae) overwinters concurrently in egg and adult stage in Central Europe. This rare overwintering strategy goes with longevity ofthis species. Adults can survive two winters in Central Europe, unlike other semiaquatic bugs. Scandinavian populations of V. caprai and water striders Gerris lacustris and G. lateralis were examined at the beginning and end of September to determine their life histories. Both gerrids start to overwinter during September, females prior to males and macropterous individuals prior to brachypterous. All females of G. lacustris and G. lateralis enter reproductive diapause before winter. V. caprai overwinters in both adult and egg stage in Norway, and can probably survive two winters. Central European and Scandinavian populations of V. caprai share the same unusual way of overwintering and probably also the whole life history

Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement

summary:The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production in the form of a system of ordinary differential equations. First, we tested the model features under periodic dosing, and subsequently, we provided an innovative method for a parameter estimation based on the periodic dosing response measurement. A numerical example approved the satisfactory behavior of the proposed algorithm

Regulatory network of drug-induced enzyme production: parameter estimation based on the periodic dosing response measurement

summary:The common goal of systems pharmacology, i.e. systems biology applied to the field of pharmacology, is to rely less on trial and error in designing an input-output systems, e.g. therapeutic schedules. In this paper we present, on the paradigmatic example of a regulatory network of drug-induced enzyme production, the further development of the study published by Duintjer Tebbens \textit{et al}. (2019) in the Applications of Mathematics. Here, the key feature is that the nonlinear model in form of an ODE system is controlled (or periodically forced) by an input signal being a drug intake. Our aim is to test the model features under both periodic and nonrecurring dosing, and eventually to provide an innovative method for a parameter estimation based on the periodic dosing response measurement

On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy

summary:A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence of that parameter on the solution of the model's system of ordinary differential equations is given and it is pointed out that some ingredients of the analysis might be useful for more general pharmacodynamic models. Numerical experiments are presented to illustrate the performance of related parameter estimation procedures based on least-squares minimization

On a stepladder model walking (with and without a decorator)

The work of Pavel Polach was originated in the framework of institutional support for the long time conception development of the research institution provided by the Ministry of Industry and Trade of the Czech Republic to Research and Testing Institute Plzen. The work of St ˇ epˇ an Pap ´ a´cek was supported by the Czech Science Foundation through the research grant ˇ No. 21-03689S. Roman Proky´sek supported his work by himself

On tank hydrodynamics of recirculating aquaculture systems: Computational fluid dynamics modeling and its validation

This work was supported by the MEYS of the Czech Republic – projects CENAKVA (No. CZ.1.05/2.1.00/01.0024), CENAKVA II (No. LO1205 under the NPU I program), by AQUAEX CEL, and by AQUAEXCEL3.0 research infrastructure project funded under the EU Horizon 2020 research and innovation programme (grant agreement No. 871108)

On a class of biped underactuated robot models with upper body: Sensitivity analysis of the walking performance

the research grant No. 21-03689

Advanced Computational Fluid Dynamics Study of the Dissolved Oxygen Concentration within a Thin-Layer Cascade Reactor for Microalgae Cultivation

High concentration of dissolved oxygen within microalgae cultures reduces the performance of corresponding microalgae cultivation system (MCS). The main aim of this study is to provide a reliable computational fluid dynamics (CFD)-based methodology enabling to simulate two relevant phenomena governing the distribution of dissolved oxygen within MCS: (i) mass transfer through the liquid–air interface and (ii) oxygen evolution due to microalgae photosynthesis including the inhibition by the same dissolved oxygen. On an open thin-layer cascade (TLC) reactor, a benchmark numerical study to assess the oxygen distribution was conducted. While the mass transfer phenomenon is embedded within CFD code ANSYS Fluent, the oxygen evolution rate has to be implemented via user-defined function (UDF). To validate our methodology, experimental data for dissolved oxygen distribution within the 80 meter long open thin-layer cascade reactor are compared against numerical results. Moreover, the consistency of numerical results with theoretical expectations has been shown on the newly derived differential equation describing the balance of dissolved oxygen along the longitudinal direction of TLC. We argue that employing our methodology, the dissolved oxygen distribution within any MCS can be reliably determined in silico, and eventually optimized or/and controlled