PeerNomination : relaxing exactness for increased accuracy in peer selection

In peer selection agents must choose a subset of themselves for an award or a prize. As agents are self-interested, we want to design algorithms that are impartial, so that an individual agent cannot affect their own chance of being selected. This problem has broad application in resource allocation and mechanism design and has received substantial attention in the artificial intelligence literature. Here, we present a novel algorithm for impartial peer selection, PeerNomination, and provide a theoretical analysis of its accuracy. Our algorithm possesses various desirable features. In particular, it does not require an explicit partitioning of the agents, as previous algorithms in the literature. We show empirically that it achieves higher accuracy than the exiting algorithms over several metrics

Nanoroughness, Surface Chemistry and Drug Delivery Control by Atmospheric Plasma Jet on Implantable Devices

Implantable devices need specific tailored surface morphologies and chemistries to interact with the living systems or to actively induce a biological response also by the release of drugs or proteins. These customised requirements foster technologies that can be implemented in additive manufacturing systems. Here we present a novel approach based on spraying processes that allows to control separately topographic features in the submicron range ( 3d 60 nm - 2 \ub5m), ammine or carboxylic chemistry and fluorophore release even on temperature sensitive biodegradable polymers such as polycaprolactone (PCL). We developed a two-steps process with a first deposition of 220 nm silica and poly(lactic-co-glycolide) (PLGA) fluorescent nanoparticles by aerosol followed by the deposition of a fixing layer by atmospheric pressure plasma jet (APPJ). The nanoparticles can be used to create the nano-roughness and to include active molecule release, while the capping layer ensures stability and the chemical functionalities. The process is enabled by a novel APPJ which allows deposition rates of 10 - 20 nm\ub7s-1 at temperatures lower than 50 \ub0C using argon as process gas. This approach was assessed on titanium alloys for dental implants and on PCL films. The surfaces were characterized by FT-IR, AFM and SEM. Titanium alloys were tested with pre-osteoblasts murine cells line, while PCL film with fibroblasts. Cell behaviour was evaluated by viability and adhesion assays, protein adsorption, cell proliferation, focal adhesion formation and SEM. The release of a fluorophore molecule was assessed in the cell growing media, simulating a drug release. Osteoblast adhesion on the plasma treated materials increased by 20% with respect to commercial titanium alloys implants. Fibroblast adhesion increased by a 100% compared to smooth PCL substrate. The release of the fluorophore by the dissolution of the PLGA nanoparticles was verified and the integrity of the encapsulated drug model confirmed

DYSMORPHIC features and adult short stature: possible clinical markers of KBG syndrome

BackgroundGrowth monitoring is an essential part of primary health care in children and short stature is frequently regarded as a relatively early sign of poor health. The association of short stature and dysmorphic features should always lead to exclude an underlying syndromic disorder.Case presentationWe report the case of an Indian school-aged boy with dysmorphic features, intellectual disability and a clinical history characterized by seizures and hearing problems. Although his height was always included in the normal range for age and sex throughout childhood, he presented a short near-adult stature in relation to his mid-parent sex-adjusted target height. This is probably due to a rapidly progressive pubertal development.ConclusionsIn the presence of characteristic dysmorphic features, intellectual disability, seizures and hearing problems, KBG syndrome should always be considered. This emergent condition presents a wide spectrum of clinical phenotypes and is often associated with adult short stature

Phenotypic Overlap in Children with Tall Stature: A Case of Weaver Syndrome

Introduction: Tall stature is defined as length or height more than two standard deviations above the mean for age of the refer- ence population. There are different causes of tall stature from a familial trait or a transient anticipation of growth with no major consequences to growth disorders, such as endocrine disorder and syndromic conditions like overgrowth syndromes. Case Presentation: In this study, we reported the case of a 7-year-old girl with tall stature from birth. The patient showed a general- ized overgrowth, associated with extremely advanced bone age, dysmorphic features such as a broad forehead and large extremities, and a slight neurodevelopmental delay. Laboratory tests were normal, and the main hormonal disorders were ruled out. The diag- nosis of overgrowth syndrome was suspected according to the clinical presentation, and the diagnosis of Weaver syndrome was confirmed by the finding of the pathogenic mutation c.2050C > T p.(Arg684Cys) in EZH2 gene through next generation sequencing (NGS). Conclusions: Our patient showed phenotypical features related to different overgrowth syndrome characteristics. We underlined the difficulties in reaching a clinical diagnosis in presence of tall stature. The role of molecular biology, particularly genetic analysis by NGS approach, should be considered in cases of tall stature with phenotypic overlap

Fluvial inverse modelling for inferring the timing of Quaternary uplift in the Simbruini range (Central Apennines, Italy)

The regional topography of the Central Apennines results from convergence between the African and Eurasian plates that led to the formation of a Neogene NE-verging imbricate fold and thrust belt. During the final stages of the orogenic deformations, the whole area was affected by strong uplift and by extensional faulting oriented along the main direction of the Apennine chain. In this framework, the landscape evolution in subaerial conditions started diachronically and is testified by the relicts of clastic deposit at different height from base levels of the present drainage network. In the Simbruini range, there are no absolute dating records neither of the most ancient clastic units deposited after the Messinian thrust-top facies nor of tectonic events. Trying to fill this gap, we used geomorphometric analyses to infer the timing of the recent phases of the tectonic history of the Simbruini range. Specifically, we identified the main non-lithological knickpoints along the river longitudinal profiles, clustered their altimetric distribution and correlated them with the levels of continental clastic deposits reserved at different elevations. Furthermore, we inferred the uplift history of the range by applying the inverse modelling of the river longitudinal profiles. Assuming a block uplift model, the drainage network cutting the Simbruini range recorded on average about 2.4 Myr of tectonic history, characterized by variable base level fall rates (corresponding to uplift rates). According the average tectonic history, the highest base level fall rate of 690 m My-1 was reached at 1.65 Ma, followed by the minimum of about 370 m My-1 , reached at 0.75 Ma, and by a second rise, up to a present-day value of 660 m My-1

PeerNomination : a novel peer selection algorithm to handle strategic and noisy assessments

In peer selection a group of agents must choose a subset of themselves, as winners for, e.g., peer-reviewed grants or prizes. We take a Condorcet view of this aggregation problem, assuming that there is an objective ground-truth ordering over the agents. We study agents that have a noisy perception of this ground truth and give assessments that, even when truthful, can be inaccurate. Our goal is to select the best set of agents according to the underlying ground truth by looking at the potentially unreliable assessments of the peers. Besides being potentially unreliable, we also allow agents to be self-interested, attempting to influence the outcome of the decision in their favour. Hence, we are focused on tackling the problem of impartial (or strategyproof) peer selection -- how do we prevent agents from manipulating their reviews while still selecting the most deserving individuals, all in the presence of noisy evaluations? We propose a novel impartial peer selection algorithm, PeerNomination, that aims to fulfil the above desiderata. We provide a comprehensive theoretical analysis of the recall of PeerNomination and prove various properties, including impartiality and monotonicity. We also provide empirical results based on computer simulations to show its effectiveness compared to the state-of-the-art impartial peer selection algorithms. We then investigate the robustness of PeerNomination to various levels of noise in the reviews. In order to maintain good performance under such conditions, we extend PeerNomination by using weights for reviewers which, informally, capture some notion of reliability of the reviewer. We show, theoretically, that the new algorithm preserves strategyproofness and, empirically, that the weights help identify the noisy reviewers and hence to increase selection performance

Thermal-induced phase transitions in self-assembled mesostructured films studied by small-angle X-ray scattering

Two examples of phase transition in self-assembled mesostructured hybrid thin films are reported. The materials have been synthesized using tetraethoxysilane as the silica source hydrolyzed with or without the addition of methyltriethoxysilane. The combined use of transmission electron microscopy, small-angle X-ray scattering and computer simulation has been introduced to achieve a clear identification of the organized phases. A structural study of the self-assembled mesophases as a function of thermal treatment has allowed the overall phase transition to be followed. The initial symmetries of mesophases in as-deposited films have been linked to those observed in samples after thermal treatment. The monodimensional shrinkage of silica films during calcination has induced a phase transition from face-centered orthorhombic to body-centered cubic. In hybrid films, instead, the phase transition has not involved a change in the unit cell but a contraction of the cell parameter normal to the substrate

Multimodal Imaging of Macular Telangiectasia Type 2: Focus on Vascular Changes Using Optical Coherence Tomography Angiography

PURPOSE. To report morphologic features of idiopathic macular telangiectasia (MacTel) type 2 by means of optical coherence tomography angiography (OCTA) and to compare these findings to fundus fluorescein angiography (FFA), fundus autofluorescence (FAF), confocal blue reflectance (CBR), and spectral-domain OCT (SD-OCT). In addition, foveal vessel density and parafoveal vascular density (PFVD), and foveal retinal thickness and parafoveal retinal thickness (PFRT) were compared between MacTel 2 patients and normal aged-matched controls. METHODS. Eight patients (15 eyes) with MacTel 2 and 17 normal controls (17 eyes) underwent retinal multimodal imaging assessment and grading. Results from different imaging techniques were used to compare interimaging modalities. Objective quantification of retinal vessel density and macular thickness was evaluated in MacTel 2 patients (15 eyes). RESULTS. In MacTel 2 eyes a comparison of OCTA to the other imaging techniques showed that the strongest correlations were present with SD-OCT, early FFA, and late FFA. Moderate correlations were found between OCTA and CBR and FAF. Foveal vessel density was significantly lower in MacTel 2 eyes than control eyes both in the superficial plexus (23.74% vs. 33.14%; P = 0.003) and in the deep plexus (24.63% vs. 34.21%; P = 0.005). Superficial PFVD was significantly different in the two groups (47.06% vs. 51.40%; P = 0.005) but not the deep PFVD. Foveal retinal thickness was 214.13 mu m in MacTel 2 eyes and 258.18 mu m in normal controls, and PFRT was 279.60 and 323.29 mu m, respectively (P CONCLUSIONS. Optical coherence tomography angiography is useful for retinal vasculature characterization in MacTel type 2 patients and showed a high correlation with well-established imaging techniques

Nonlinear optical properties of Au–Ag nanoplanets made by ion beam processing of bimetallic nanoclusters in silica

The nonlinear absorption of Au–Ag nanoplanets made by Ar irradiation of bimetallic nanoclusters in silica has been experimentally investigated by means of the single beam z-scan technique. The measurements have been performed in the picoseconds regime in order to isolate the fast electronic contribution to the third-order nonlinearity. The results reveal large nonlinear absorption properties of these systems, characterized by the concomitance of saturable and reverse saturable absorption. A phenomenological expression has been developed to fit the z-scan curves and to quantitatively determine the nonlinear optical parameters