Correction to: Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

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Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective

Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three-dimensional in vitro model in screening protocols. In this brief work, we discuss some of the issues that cancer nanomedicine will need to consider in the switch from bi-dimensional to three-dimensional multicellular tumor spheroid models

Applicazione di Lean Manufacturing e TPM nel settore della produzione dei nastri adesivi: il caso VIBAC

L'obiettivo della tesi è l'applicazione delle tecniche di lean manufacturing in ambito aziendale e delle metodiche della TPM (Total Productive Maintenance).L'analisi è stata effettuata su un impianto pilota del reparto taglio in affiancamento agli operatori di macchina e al tutor aziendale, responsabile della manutenzione di stabilimento.E' stato creato un team di lavoro con le figure responsabili dei vari reparti(produzione, manutenzione, officina) con i quali si è monitorato l'avanzamento del progetto.Le principali tematiche trattate sono state: l'implementazione delle 5S, procedure di avviamento e spegnimento,tecniche di visual management, la manutenzione autonoma, analisi delle cause di fermata/guasto dell'impianto, installazione di un nuovo indicatore di performance e progettazione della gestione del fabbisogno materiali. Sviluppi futuri prevedono l'implementazione delle metodiche a tutti i reparti e impianti dello stabilimento

Suitability of ground-based SfM-MVS for monitoring glacial and periglacial processes

Photo-based surface reconstruction is rapidly emerging as an alternative survey technique to lidar (light detection and ranging) in many fields of geoscience fostered by the recent development of computer vision algorithms such as structure from motion (SfM) and dense image matching such as multi-view stereo (MVS). The objectives of this work are to test the suitability of the ground-based SfM-MVS approach for calculating the geodetic mass balance of a 2.1km2 glacier and for detecting the surface displacement of a neighbouring active rock glacier located in the eastern Italian Alps. The photos were acquired in 2013 and 2014 using a digital consumer-grade camera during single-day field surveys. Airborne laser scanning (ALS, otherwise known as airborne lidar) data were used as benchmarks to estimate the accuracy of the photogrammetric digital elevation models (DEMs) and the reliability of the method. The SfM-MVS approach enabled the reconstruction of high-quality DEMs, which provided estimates of glacial and periglacial processes similar to those achievable using ALS. In stable bedrock areas outside the glacier, the mean and the standard deviation of the elevation difference between the SfM-MVS DEM and the ALS DEM was-0.42 \ub1 1.72 and 0.03 \ub1 0.74 m in 2013 and 2014, respectively. The overall pattern of elevation loss and gain on the glacier were similar with both methods, ranging between-5.53 and + 3.48 m. In the rock glacier area, the elevation difference between the SfM-MVS DEM and the ALS DEM was 0.02 \ub1 0.17 m. The SfM-MVS was able to reproduce the patterns and the magnitudes of displacement of the rock glacier observed by the ALS, ranging between 0.00 and 0.48 m per year. The use of natural targets as ground control points, the occurrence of shadowed and low-contrast areas, and in particular the suboptimal camera network geometry imposed by the morphology of the study area were the main factors affecting the accuracy of photogrammetric DEMs negatively. Technical improvements such as using an aerial platform and/or placing artificial targets could significantly improve the results but run the risk of being more demanding in terms of costs and logistics

Strategies to improve the structural integrity of tied-arch bridges affected by instability phenomena

Abstract A numerical study is proposed to investigate the nonlinear behavior of steel tied-arch bridges, whose arch ribs are inclined inwardly. The main aim of the paper is to assess if the arch rib inclination may be an effective strategy to enhance the structural integrity of the bridge structure against out-of-plane buckling mechanisms. The nonlinear behavior of the structure is investigated throughout an advanced 3D finite element model, which accurately reproduces nonlinear sources involved in the cable system and structural elements. An analysis that combines results obtained by traditional elastic buckling analysis and incremental nonlinear elastic analysis is employed to properly evaluate the maximum capacity of the structure. Comparisons between bridge structures with inclined and vertical ribs configurations are proposed focusing attention on both structural and economic aspects. Results show that rib inclination provides several structural benefits to the bridge while reducing overall construction costs

The Ventasso Horse: genetic characterization by microsatellites markers

The genetic structure of Ventasso Horse (VH) was investigated using 12 microsatellites. The analyses were carried out on 117 VH individuals and the results were compared with those obtained analysing 11 other breeds reared in Italy. All microsatellites were polymorphic in VH and in the other breeds. A total of 124 alleles (from 6 to 19 alleles per microsatellite) were detected. Average heterozygosity was 0.743 in VH and ranged from 0.613 to 0.759 in the other breeds. The mean FST value had an average value of 0.0932. Genetic distances were calculated using Nei's standard genetic distance (Ds). The smallest Ds values were found between VH and Anglo-Arab, Thoroughbred, Maremmano and Lipizzan horse breeds. Phylogenetic trees constructed using neighbour-joining method showed two clear separate clusters: the first includes Bardigiano, Haflinger and Italian Heavy Draught Horse, the second contains the other 9 breeds

Renormalization and finiteness of topological BF theories

We show that the BF theory in any space-time dimension, when quantized in a certain linear covariant gauge, possesses a vector supersymmetry. The generator of the latter together with those of the BRS transformations and of the translations form the basis of a superalgebra of the Wess-Zumino type. We give a general classification of all possible anomalies and invariant counterterms. Their absence, which amounts to ultraviolet finiteness, follows from purely algebraic arguments in the lower-dimensional cases.Comment: 27 p., Latex fil

Small-Angle X-ray Scattering Unveils the Internal Structure of Lipid Nanoparticles

Lipid nanoparticles own a remarkable potential in nanomedicine, only partially disclosed. While the clinical use of liposomes and cationic lipid-nucleic acid complexes is well-established, liquid lipid nanoparticles (nanoemulsions), solid lipid nanoparticles, and nanostructured lipid carriers have even greater potential. However, they face obstacles in being used in clinics due to a lack of understanding about the molecular mechanisms controlling their drug loading and release, interactions with the biological environment (such as the protein corona), and shelf-life stability. To create effective drug delivery carriers and successfully translate bench research to clinical settings, it is crucial to have a thorough understanding of the internal structure of lipid nanoparticles. Through synchrotron small-angle X-ray scattering experiments, we determined the spatial distribution and internal structure of the nanoparticles' lipid, surfactant, and the water in them. The nanoparticles themselves have a barrel-like shape that consists of coplanar lipid platelets (specifically cetyl palmitate) that are partially covered by polysorbate 80 surfactant and retain a small amount of hydration water. Although the platelet structure was expected, the presence of surfactant molecules forming sticky patches between adjacent platelets challenges the classical core-shell model used to describe solid lipid nanoparticles. Additionally, the surfactant partially covers the water-nanoparticle interface, allowing certain lipid regions to come into direct contact with surrounding water. These structural features play a significant role in drug loading and release, biological fluid interaction, and nanoparticle stability, making these findings valuable for the rational design of lipid-based nanoparticles.Comment: 22 pages, 11 figure

Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis

Exacerbations of chronic bronchitis (AECB) are a major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and their impact on public health is increasing. The new fluoroquinolones have an excellent spectrum providing cover for the most important respiratory pathogens, including atypical and “typical” pathogens. Not surprisingly, different guidelines have inserted these agents among the drugs of choice in the empirical therapy of AECB. The pharmacokinetic and dynamic properties of the new fluoroquinolones have a significant impact on their clinical and bacteriological efficacy. They cause a concentration-dependent killing with a sustained post-antibiotic effect. This review discusses the most recent data on the new fluoroquinolone prulifloxacin and critically analyses its activity and safety in the management of AECB