I paradossi dell'affidamento familiare tra separazione e appartenenza, connessione e distanza. L'esperienza del Centro affidi di Massa.

La tesi affronta l'affidamento familiare a vari livelli: giuridico, sociale e nella prassi operativa. Il focus della dissertazione è il concetto di temporaneità, aspetto saliente dell'istituto; il tentativo è quello di far emergere le criticità che tale assunto porta con sè, nonchè di mettere in evidenza la necessità di cambiamenti da apportare all'istituto stesso dell'affidamento. Si propone un nuovo approccio al concetto di "rientro", che non equivalga, necessariamente ad un riavvicinamento fisico, bensì ad una riunificazione affettiva

Real-practice thromboprophylaxis in atrial fibrillation

This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of 6,138 NVAF patients, only 3,024 received Vitamin K antagonist (VKA). Potential barriers decreasing the probability of being treated with VKA were female sex, older age, antiplatelet treatment and history of bleeding. In addition, VKA-treatment was not in line with current ESC and AIAC guidelines, since the patients at high or low risk of stroke were under-or over-treated, resp. Among VKAtreated patients, 73 % of subjects were not at target with anticoagulation. OAT resulted to be effective in reducing stroke risk. However, stroke events were significantly influenced also by previous stroke or transient ischemic attack (hazard ratio, HR = 2.99, p < 0.001) and by previous bleeding events (HR = 1.60, p < 0.001)

Exotic atoms at extremely high magnetic fields: the case of neutron star atmosphere

The presence of exotic states of matter in neutron stars (NSs) is currently an open issue in physics. The appearance of muons, kaons, hyperons, and other exotic particles in the inner regions of the NS, favored by energetic considerations, is considered to be an effective mechanism to soften the equation of state (EoS). In the so-called two-families scenario, the softening of the EoS allows for NSs characterized by very small radii, which become unstable and convert into a quark stars (QSs). In the process of conversion of a NS into a QS material can be ablated by neutrinos from the surface of the star. Not only neutron-rich nuclei, but also more exotic material, such as hypernuclei or deconfined quarks, could be ejected into the atmosphere. In the NS atmosphere, atoms like H, He, and C should exist, and attempts to model the NS thermal emission taking into account their presence, with spectra modified by the extreme magnetic fields, have been done. However, exotic atoms, like muonic hydrogen $(p\,\mu^-)$ or the so-called Sigmium $(\Sigma^+\,e^-)$, could also be present during the conversion process or in its immediate aftermath. At present, analytical expressions of the wave functions and eigenvalues for these atoms have been calculated only for H. In this work, we extend the existing solutions and parametrizations to the exotic atoms $(p\,\mu^-)$ and $(\Sigma^+\,e^-)$, making some predictions on possible transitions. Their detection in the spectra of NS would provide experimental evidence for the existence of hyperons in the interior of these stars.Comment: 10 pages, 6 figures, proceedings of the "International Conference on Exotic Atoms and Related Topics - EXA2017", Austrian Academy of Sciences, Austria, September 11-15, 201

Improvement in ACE I/D polymorphism detection

The ACE I/D polymorphism has been reported to influence predisposition to cardiovascular disease. Conflicting results in its detection may be due to mistyping of I/D genotypes as D/D genotypes occurring in the traditional genotyping method. In order to resolve mistyping troubles and to permit a rapid and accurate analysis, we performed a stepdown PCR reaction followed by detection using Nanogen technology, and we compared these results with those obtained from traditional genotyping methods, such as conventional and confirmatory PCR. The Nanogen stepdown method showed a 100% sensitivity and 99.6% specificity, when compared with the confirmatory PCR. Our experiments provide evidence that, by using the Nanogen stepdown method, the DD mistyping was markedly decreased, thus representing a useful tool suitable for performing large-scale screening or research

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1)

Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid β (Aβ) accumulation, and progressive neurodegeneration. Cdk5 is a proline-directed serine/threonine kinase whose activation by the p25 protein has been implicated in a number of neurodegenerative disorders. The CK-p25 inducible mouse model exhibits progressive neuronal death, elevated Aβ, reduced synaptic plasticity, and impaired learning following p25 overexpression in forebrain neurons. Levels of Aβ, as well as the APP processing enzyme, β-secretase (BACE1), are also increased in CK-p25 mice. It is unknown what role increased Aβ plays in the cognitive and neurodegenerative phenotype of the CK-p25 mouse. In the current work, we restored Aβ levels in the CK-p25 mouse to those of wild-type mice via the partial genetic deletion of BACE1, allowing us to examine the Aβ-independent phenotype of this mouse model. We show that, in the CK-p25 mouse, normalization of Aβ levels led to a rescue of synaptic and cognitive deficits. Conversely, neuronal loss was not ameliorated. Our findings indicate that increases in p25/Cdk5 activity may mediate cognitive and synaptic impairment via an Aβ-dependent pathway in the CK-p25 mouse. These findings explore the impact of targeting Aβ production in a mouse model of neurodegeneration and cognitive impairment, and how this may translate into therapeutic approaches for sporadic AD.National Institutes of Health (U.S.) (Grant NIH R01NS051874)Ruth L. Kirschstein National Research Service Award (Predoctoral Fellowship F31GM80055-03

El contexto de los repositorios de acceso abierto en la Argentina: logros y asuntos pendientes

Esta presentación contiene: * 11 años de los Sistemas Nacionales: una Política de Estado (SGCTIP) * SNRD * Lo que viene… Nuevas Directrices * Interoperabilidad * Los principales cambios * Ley nº26.899 de repositorios * ¿Qué deben incluir las Políticas Institucionales de AA? * ¿Cuáles son los problemas más frecuentes detectados en las políticas institucionales? * Grado de adecuación de las instituciones de CyT de Argentina a la Ley 26.899 de Acceso Abierto. Octubre 2019 * ¿Cómo se puede verificar la adecuación de las Políticas Institucionales de Acceso Abierto a la Ley? * Herramienta de apoyo * Asuntos PendientesServicio de Difusión de la Creación Intelectua

El contexto de los repositorios de acceso abierto en la Argentina: logros y asuntos pendientes

Esta presentación contiene: * 11 años de los Sistemas Nacionales: una Política de Estado (SGCTIP) * SNRD * Lo que viene… Nuevas Directrices * Interoperabilidad * Los principales cambios * Ley nº26.899 de repositorios * ¿Qué deben incluir las Políticas Institucionales de AA? * ¿Cuáles son los problemas más frecuentes detectados en las políticas institucionales? * Grado de adecuación de las instituciones de CyT de Argentina a la Ley 26.899 de Acceso Abierto. Octubre 2019 *¿Cómo se puede verificar la adecuación de las Políticas Institucionales de Acceso Abierto a la Ley? * Herramienta de apoyo * Asuntos Pendiente

El contexto de los repositorios de acceso abierto en la Argentina: logros y asuntos pendientes

Esta presentación contiene: * 11 años de los Sistemas Nacionales: una Política de Estado (SGCTIP) * SNRD * Lo que viene… Nuevas Directrices * Interoperabilidad * Los principales cambios * Ley nº26.899 de repositorios * ¿Qué deben incluir las Políticas Institucionales de AA? * ¿Cuáles son los problemas más frecuentes detectados en las políticas institucionales? * Grado de adecuación de las instituciones de CyT de Argentina a la Ley 26.899 de Acceso Abierto. Octubre 2019 *¿Cómo se puede verificar la adecuación de las Políticas Institucionales de Acceso Abierto a la Ley? * Herramienta de apoyo * Asuntos Pendiente