20 research outputs found
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
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- Bagetta G
- Bagniewska-Zadworna A
- Bai H
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- Bai X
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- Balazadeh S
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- Baldari CT
- Balduini W
- Ballabio A
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- Balzan R
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- Banerjee S
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- Bao Y
- Baptista MS
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- Barreiro E
- Barreto GE
- Bartek J
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- Bartolome A
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- Baulieu EE
- Baumgarner BL
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- Beaumatin F
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- Benbrook DM
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- Benitez BA
- Benito-Cuesta I
- Bensalem J
- Berchtold MW
- Berezowska S
- Bergamaschi D
- Bergami M
- Bergmann A
- Berliocchi L
- Berlioz-Torrent C
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- Besirli CG
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- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
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- Bhutia SK
- Bi L
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- Biden TJ
- Bijian K
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- Boone BA
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- Braus GH
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- Bravo-San Pedro JM
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- Bringer M-A
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- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
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- Buckingham EM
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- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- Burón MI
- Bustos V
- Butturini E
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- Büttner S
- Cabas I
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- Cadwell K
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- Caldwell GA
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- Call JA
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- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- Cantí C
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- Caraglia M
- Caramés B
- Carchman EH
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- Cardenas C
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- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
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- Carroll B
- Carter AB
- Carvalho AN
- Casanova M
- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
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- Chakrabarti G
- Chakrabarti O
- Chakraborty T
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- Chami M
- Chamilos G
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- Chan H
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- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
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- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
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- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
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- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
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- Collins MO
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- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
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- Cui Y
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- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
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- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
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- Dash S
- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
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- Dayalan Naidu S
- De Amicis F
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- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
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- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
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- Di Leo L
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- Di Sano F
- Diallinas G
- Diao J
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- Dickinson JM
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- Dikic I
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- Dinkova-Kostova AT
- Dionne MS
- Distler JHW
- Diwan A
- Dixon IMC
- Djavaheri-Mergny M
- Dobrinski I
- Dobrovinskaya O
- Dobrowolski R
- Dobson RCJ
- Dokmeci Emre S
- Donadelli M
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- Emerling BM
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- Figueras A
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- Frankel LB
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- Kim DR
- Kim E-K
- Kim EY
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
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- Acevedo-Arozena A.
- Adamopoulos I. E.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Fast Rendering of Diffusion Curves with Triangles
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- Field of study
Analysis of ESTs generated from inner bark tissue of an Acacia auriculiformis x Acacia mangium hybrid
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
The majority of plant expressed sequence tags (ESTs) available in the public databases are from non-woody species such as Arabidopsis, maize, soybean, and rice, with the exception of the model tree species, Populus. In this study, we report the first EST database constructed from the commercially important tree species Acacia. ESTs were generated from pooled RNA extracted from the mature, intermediate, and young inner bark tissues of an Acacia auriculiformis x Acacia mangium hybrid. Finally, 3,182 high-quality ESTs were analyzed representing a total of 1,982 unique transcripts (663 contigs and 1,319 singletons) for the inner bark cDNA library. A total of 1,053 unigenes (1,750 ESTs) showed similarities with protein sequences in public database where 867 were significant matches (E value ≤ e-10). Further analysis performed on unigenes with significant matches and known functions identified 231 genes including genes involved in cellulose, lignin, and hemicellulose biosynthesis. For cDNA library validation, quantitative real-time RT-PCR was performed to study the expression levels of the cellulose and lignin genes identified from this EST database in the phloem tissue of A. mangium, A. auriculiformis, and A. auriculiformis x A. mangium hybrid. All the seven candidate genes were expressed in all the individuals studied confirming the dependability of the EST database. The cDNA library and the EST database constructed are valuable resources for forest tree research aiming towards understanding the genetic control of wood formation and in the future endeavors to modify wood and fiber profile through marker-assisted breeding programs. © 2010 Springer-Verlag
Effect of Packet Loss on Collaborative Haptic Interactions in Networked Virtual Environments: An Experimental Study
- Author
- Publication venue
- 'MIT Press - Journals'
- Publication date
- Field of study
A framework using cluster-based hybrid network architecture for collaborative virtual surgery
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Improving the discrimination of hand motor imagery via virtual reality based visual guidance
- Author
- Arvaneh
- Babiloni
- Blankertz
- Daly
- Duda
- Ertelt
- Higashi
- Hoffmann
- Huang
- Jackson
- Jasper
- Jing Qin
- Kup-Sze Choi
- Leocani
- McFarland
- McFarland
- Muthukumaraswamy
- Neuper
- Neuper
- Oberman
- Ono
- Peter
- Pfurtscheller
- Pfurtscheller
- Pfurtscheller
- Pfurtscheller
- Pfurtscheller
- Pfurtscheller
- Pfurtscheller
- Pfurtscheller
- Pheng-Ann Heng
- Prasad
- Qiong Wang
- Rizzolatti
- Shin
- Shuang Liang
- Vidaurre
- Wai-Man Pang
- Wolpaw
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Net Zero Stocktake 2023
- Author
- Abdelaziz Sara
- Acikalin Duygu
- Adams Bethan
- Ahn Da Eun
- Apenuwa Oluwaseun
- Barnes Amelia
- Beever Anna
- Bill Carys
- Booth Amy
- Borthakur Barasha
- Boyer Samuel
- Boyes Kiyomi
- Brown Sophie
- Cairns Gabriel
- Candler Annamarie
- Collett Max
- Collin Alex
- Coulthard Claire
- Dantas Luna
- Dariye Ebenezer
- Dunn Alexander
- Efthimiou Athena
- El Kilany Marwan
- Fan Nicole
- Fowks Lyndsey
- Galang John Bervin
- Glanz Ben
- Gonzales Julian
- Hard Af Segerstad-Smith Mia
- Harris Arianwen
- Hooseria Sitara
- Hu Andrew
- Hylton Amelie
- Hyslop Camilla
- James Molly
- Janiurek Amba
- Jones Oscar
- Kamenkovich , Nadya
- Katalan Nasi Alp
- Kennelly Roisin
- Kline Kyle
- Konle Jana
- Kunde Hayley
- Laughton Isobel
- Layton Esme
- Le Angela
- Lee Seoyoung
- Linehan-Hill Harry
- Lutz Natasha
- Maddinson Charlotte
- Main Lucy
- Monikowska Laura
- Murrell Cassandra
- Muza Mitchel
- Needham-Hewavisenti Ella
- Newton Alexander
- O'Keeffe Fergus
- Palacio Sasse Lucia
- Pang Sze Ann
- Parker Rosa
- Perry Jocelyn
- Prince Nolwen
- Ray Shannon
- Reid Phoebe
- Robertson Maddy
- Sakari Rita R
- Sarro Caitlin
- Seo Heejung
- Shen Qicheng
- Shen Richard
- Sherif Sana
- Shrestha Kunja
- Spacey Martin Roberto
- Speake Emily
- Sun Ann
- Tam Claudia
- Taylor Haroon
- Teginbayev Daulet
- Thu Nayah
- Troiano Mattia
- Trung Irene
- Usman Ibrahim
- Von Alten-Reuss Gabriella
- Wallock William
- Wang Hantao
- Ward Josephine
- Xia Minqi
- Zhukova Anna
- Zionts Jessica
- Publication venue
- Zenodo
- Publication date
- 12/06/2023
- Field of study
The underlying dataset for the Net Zero Tracker's Net Zero Stocktake Report 2023
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- António Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecile Yelnik
- Cedric Laouenan
- Ceila Sant'Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chloe Donohue
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
- Claire Lévy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Clotilde Allavena
- Clément Le Bihan
- Colin McArthur
- Coline Jaud-Fischer
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cédric Joseph
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Dafsah Juzar
- Damien Bouhour
- Daniel Glikman
- Daniel Haber
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- David L. Robertson
- David Maslove
- David Richardson
- David S.Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Debby Bogaert
- Deepashankari Suppiah
- Dehbia Benkerrou
- Delphine Bachelet
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- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana Adrião
- Diana Hernández
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Fernando Rincon
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dyah Kanya Wati
- Dzawani Muhamad
- Eder Caceres
- Edmund Manning
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elise Artaud-Macari
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Ema Leal
- Eman Al Qasim
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L'her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Félix Djossou
- Gabriel Macheda
- Gail Carson
- Gamage Dona Priyadarshani
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Gilles Peytavin
- Giri Shan Rajahram
- Giulia Bertoli
- Graham S. Cooke
- Grazielle Viana Ramos
- Gry Kloumann Bekken
- Grégory Corvaisier
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
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- Gwenhaël Colin
- Ha Sha Lene
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Renk
- Hannah Habraken
- Hans Martin Bosse
- Harald Vonkeman
- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Heidi Jean Dalton
- Heng Gee Lee
- Hervé Le Nagard
- Hiba Zayyad
- Hikombo Hitoto
- Himasha Muvindi
- Himed Musaab
- Hiu Jian Chua
- Hodane Yonis
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Hugo Inácio
- Hugo Mouquet Ben Morton
- Hugues Aumaître
- Hugues Cordel
- Husna Begum
- Hwa Jin Cho
- Hélène Espérou
- Hélène Salvator
- Ikram Houas
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- Ingrid G Bustos
- Irfan Khan
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
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- Sofia Cardoso
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- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasmine Kaur
- Abby Hurd
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abid Khatak
- Adam Ali
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Aftab Imtiaz
- Agamemnon Bakakos
- Agnieszka Oldakowska
- Agnès Meybeck
- Agnès Sommet
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisha Kalsoom Mufti
- Aisling Gavin
- Aisling Murphy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Alberto Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martin-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexander King
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Ait Hssain
- Ali Hachemi
- Ali Liaquat
- Ali Raza
- Alice Bogaarts
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Alison M Meynert
- Allegra Chatterjee
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Amanda Corley
- Amanda Palacios
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amin Khawaja
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Hackmann
- Amy Lester-Grant
- Amy Stone
- Amélie Valran
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anand Thakur
- Anant Kataria
- Anatoliy Gavrylov
- Anders Benjamin Kildal
- Anders Tveita
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Hershey
- Andrew Udy
- Andrey Svistunov
- Andriy Bal
- André Cabie
- André Dias
- André Roberto
- Andy Dong
- Andy Law
- Aneela Altaf
- Angel Asensio
- Angel Sanchez-Miralles
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Ankana Satya
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B Docherty
- Annmarie O Callaghan
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ricchiuto
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- António Mesquita
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Henriquez-Trujillo
- Arabella Fahy
- Ardiyan Apriyana
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsalan Rahutullah
- Arshad Taqi
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Ashraf Sheharyar
- Asim Rana
- Asma Moin
- Astarini Hidayah
- Atif Siddiqui
- Attaur Rehman
- Audrey Barrelet
- Aurelius Bonfasius
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Ayodhia Pitaloka
- Azlan Mat Soom
- B P Sanka Ruwan Sri Darshana
- Bailey Cassandra
- Baillie J Kenneth
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barrio Noelia García
- Baruch Joaquín
- Basanta Gauli
- Basri Mat Nor
- Beane Abigail
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefevre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernhard Roessler
- Bertrand Dussol
- Bianca Boxma
- Biing Horng Lee
- Birgitte Stiksrud
- Blake Mergler
- Blandine Rammaert
- Blumberg Lucille
- Bouchra Loufti
- Bozza Fernando
- Brenda Molloy
- Brenda Reeve
- Brendan Scicluna
- Brian Marsh
- Brigitte Elharrar
- Briseida Parra
- Broadley Tessa
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Budha Charan Singh
- Burrell Aidan
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Caitriona Cody
- Calvin Wong
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlos Alexandre Antunes de Brito
- Carlos Lumbreras Bermejo
- Carlos M Luna
- Carlos Pimentel
- Carmen Infante Dominguez
- Carola Pierobon
- Carolien van Netten
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Carson Gail
- Cassidy Codan
- Cassie Lawrence
- Catarina Pires
- Catarina Silva
- Catherine A Shaw
- Catherine Blier
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L Hough
- Catherine Marquis
- Catherine Motherway
- Cecile Azoulay
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Chantre Lima
- Charbel Maroun Eid
- Charlene Da Silveira
- Charles Crepy D'Orleans
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Robba
- Chiara Simona Cardellino
- Chiara Vitiello
- Chih-Hsien Wang
- Chloe Donohue
- Chris Kandel
- Chris McKay
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Buesaquillo
- Christian Prebensen
- Christian Rabaud
- Christophe Fraser
- Christophe Rapp
- Christopher A Green
- Christy Kay
- Ci Wong Xin
- Citarella Barbara Wanjiru
- Claire Andréjak
- Claire Foley
- Claire Kelly
- Claire Levy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudia Sepulveda
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Cleide Barrigoto
- Clotilde Allavena
- Clément Le Bihan
- Coilin Smyth
- Colin McArthur
- Colin McArthur
- Colin McCloskey
- Coline Jaud-Fischer
- Colleen Curran
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Cosimo Cristella
- Courtney Greene
- Cristina De Rose
- Cristinava Vajdovics
- Cynthia Alegre
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cécile Yelnik
- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
- Céline Ficko
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- Samuel Hinton
- Samuel Markowicz
- Samuel McElwee
- Sandrine Couffin-Cadiergues
- Sandulescu Oana
- Sanjay Lakhey
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Taleb
- Sara Ventura
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Seamus Daly
- Sean Donohue
- Sebastian Vencken
- Sebastiano Maria Colombo
- Segolène Greffe
- Semple Malcolm G
- Senthilkumar Alegesan
- Sergio Poli
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shakeel Ahmed
- Shaminee Veeran
- Sharma Keshav
- Sharma Pratima
- Shaun Thompson
- Shaunagh Browne
- Sheeba Hakak
- Sheila Cárcel
- Sherry McDermott
- Sheryl Ann Abdukahil
- Shinichiro Ohshimo
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Shubha Kalyan Shrestha
- Sia Loong Tonnii
- Sigfrid Louise
- Silvia Castañeda
- Silvia Lourenco
- Sim Choon Ean
- Sim Lim Heng Benedict
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Simone Carelli
- Simão Rodeia
- Singh Oinam Budha Charan
- Siobhan Casey
- Siobhan Egan
- Siri Goepel
- Siti Nurul Atikah Ahmad Ridzuan
- Siti Rohani Binti Mohd Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Smaragdi Kalomoiri
- Sobia Masood
- Sofia Cardoso
- Sofia Prapa
- Sofia Tejada
- Sofía Contreras
- Soizic Le Mestre
- Somers Emily C
- Sophie Halpin
- Sophie Mahy
- Sophie O'Halloran
- Sravya Pudota
- Sree Satyapriya
- Srinivas Murthy
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Huo
- Stella Rousset
- Stephan Schroll
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Stijn Van de Velde
- Streinu-Cercel Anca
- Stuart Houltham
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Su Hwan Lee
- Subbarao Elapavaluru
- Subhash Acharya
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Sung-Min Cho
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Cabral
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suwarti Suwarti
- Suzanne Bennett
- Suzette Willems
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Syed Muneeb
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Sílvia Ferreira
- T Eoin West
- Taccone Fabio
- Tae Song
- Taha Pasha
- Tahira Jamal Mohamed
- Tak-Hyuk Oh
- Takako Akimoto
- Takayuki Ogura
- Taku Tanaka
- Tala Al-Dabbous
- Tamara Seitz
- Tan Pei Wen
- Tarek Elshazly
- Tatiana Fonseca
- Tawnya Ogston
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Thalha Rashan
- Tharmini Ravi
- Tharwat Aisa
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tjard Schermer
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tomoyuki Endo
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Vadim Tieroshyn
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vecham Pavan Kumar
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Janes
- Victoria Manda
- Victoria McEneany
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Véronique Lemee
- Víctor Quirós González
- Wai Ching Sin
- Walter Picard
- Wan Fadzlina Wan Muhd Shukeri
- Wei Han Hoh
- Wei Shen Lim
- Wei Jia
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Wils Evert-Jan
- Wim Dieperink
- Wing Yiu Ng
- Xavier Duval
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zul Fakar
- Zulfiqar Sandhu
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 28/02/2023
- Field of study
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death