Block Chain Technology in Digital Accounting

The manual system of business process has been restricted by the Nobel Covid-19, and people have begun to work digitally. Block chain technology cannot be ignored when it comes to digitalization. Cryptocurrency and digitalization have grown far more rapidly than any other industry, and this technology is at the heart of it. Especially in the accounting field, this technology could have a major impact. It is possible that block chain technology could transform accounting from a two-entry system to a three-entry system.. As a result of this accounting fundamental need, it becomes imperative to maintain and update financial records. The transactions are recorded in real time, with full accuracy and reliability, and once the transaction is completed, it cannot be changed

A Study on Development Schemes of Rural India

Rural development is gaining global attention, especially among developing nations. It has great importance for a country such as India. It refers to the development of rural economies, which are experiencing serious poverty issues, and aims to develop their productivity. In addition, the report stresses the importance of addressing different pressing issues of village economies that impede growth and improve these areas.  The Indian government has launched several schemes to develop rural areas. A few of the major problems in rural India are the lack of housing, the lack of infrastructure in villages and towns to connect villages with all-weather roads, and the lack of employment opportunities. The purpose of this paper is to analyze the government of India has announced the Pradhan Mantri Awaas Yoiana Gramin scheme to provide homes, Pradhanmantri Gram Sadak Yojana to build roads and To provide rural people with employment opportunities, the Mahatma Gandhi National Rural Employment Guarantee Act 2005 was passed. In this study, we discover what the role of these schemes is in India's rural development, as well as how they are progressing at present

Awareness And Usage Pattern of Learner’s On ELearning Platform: A Survey

During this covid-19 pandemic situation, virtual e-learning environment is more effective and useful for learners’ and for any educational system to cater the needs. E-Learning provides opportunity to the learner’s regardless geographic location, independent of time and place. E-Learning platform helps the learners to enhance their learning skills, employability skill development, subject expertise, and research skills by which the teaching and learning strategy get increases. Learning through e- platforms develop the technical skills, exploring the knowledge, interest of learning and way to change teaching style. Through this paper, an attempt is made to understand the learner’s perception, their interactive pattern with the e- learning platforms and the organization/universities offering courses during the covid-19

Prevalence, Antibiotic Susceptibility Testing, Beta-Lactamase Production and mcr-1 Gene Detection in Uropathogenic Klebsiella Pneumoniae Isolated from A Tertiary Care Hospital in Bhopal: A Prospective Study

Introduction: Klebsiella pneumoniae (K pneumoniae) is an inhabitant of the nasopharynx and gastrointestinal tract and it is capable of causing a variety of infections, including urinary tract infection (UTI), pneumonia, liver abscess and septicemia. UTI in humans can be hospital and community-acquired. UTI should initially be treated with Co-trimoxazole, Nitrofurantoin, 1st generation cephalosporins, and Ciprofloxacin. Still, in India, frequent usage of broad-spectrum antibiotics such as cephalosporins, carbapenems and colistin for getting immediate response has led to resistance to these drugs. K pneumoniae possess several different mechanisms of drug resistance for survival. ESBL, MBL and AmpC beta-lactamase production is one of the dominant mechanisms to inactivate the beta-lactam antibiotics. UTI caused by MDR K pneumoniae is often treated with carbapenems and colistin. Inappropriate doses and frequent usage of these antibiotics make bacteria resistant therefore it is important to know about the susceptibility of antibiotics against K pneumoniae before giving broad-spectrum antibiotics in the local community for the better management of UTI. Methods: The present study is a prospective study. All clean-catch, mid-stream urine samples were collected in the sample collection centre from the patients suspecting UTI. Semi-quantitative culture method (SQCM) was used to isolate K pneumoniae. SQCM is a routinely used culture method as a diagnostic criterion for patients having a UTI. SQCM indicates the bacterial count present in the urine sample. Firstly, K pneumoniae was isolated and identified followed by Antimicrobial-susceptibility testing (AST). After the AST, double disc synergy test checked the production of ESBL, MBL and AmpC beta-lactamase. Lastly, colistin resistance in K pneumoniae was determined by the E-strip method and K pneumoniae strains positive by E-strip method were further screened for mcr-1 gene by PCR. Results: A total of 11740 urine samples were received and processed. 2465 (21%) samples showed significant growth of uropathogens. Out of all pathogens, 332 (13%) were identified as K pneumoniae.  Other 2133 (87%) pathogens were identified as Enterobacteriaceae members, Pseudomonas aeruginosa, Burkholderia, Acinetobacter baumannii, Enterococcus, and Staphylococcus. Of all the antibiotics we tested in our study, colistin (87%), carbapenems (78-79%) were the most and penicillin (00-43%) group was the least sensitive. ESBL, AmpC and MBL were 203 (61%), 126 (38%) and 83 (25%) respectively in K pneumonia. Colistin resistance was shown by 43 (13%) K pneumonia strains and out of these 43, only 08 (19%) strains were positive for mcr-1 gene

Bayesian Method in Linear Model and Constant Time Series Model Using Non- Informative Prior Under Phenology

Climate Change is very recent topic at global level for discussion for all of us. Phenology is one of the main bio- indicators to track climate change effects on ecosystem. The present study is devoted to derive results of coherent interest in the field of phenology from Bayesian point of view. In this paper we have developed the phenological probability models using linear model and constant time series model. The comparison of both the models has also been done using the concept of residual sum of square and Bayes’ factor

Neurocysticercosis with initial clinical presentation of acute cysticercal meningitis coexisting with anterior chamber intraocular cysticercosis: a case report from a rural institute in India

Acute cysticercal meningitis coexisting with intraocular cysticercosis is an extremely infrequent clinical presentation of neurocysticercosis. We report a 26 year old male, who presented with signs and symptoms of acute eosinophilic cysticercal meningitis with intraocular cysticercosis in the anterior chamber of left eye. Diagnosis was confirmed with demonstration of cerebrospinal fluid (CSF) eosinophilia, cysticercus specific IgG antibodies by CSF ELISA, sterile bacterial, mycobacterial and fungal CSF cultures, cystic lesions containing characteristic scolices consistent with neurocysticercosis on neuroimaging and histopathological demonstration of cysticercus cellulosae larva viscoexpressed from the eye. The importance of having high index of clinical suspicion highlighted along with need of examining cerebrospinal fluid with Wright-Giemsa stain so as not to miss cerebrospinal fluid eosinophilia and diagnosis of this extremely under-reported clinical entity, when there is concurrent presence of brain and other extracerebral lesions consistent with cysticercosis

Management of acute diarrhea in children: is the treatment guidelines is really implemented?

Background: Acute diarrhea is a common problem in children especially in poor and developing nations. It is one of the leading cause of under-five years’ mortality globally. The children used to die each year of dehydration and electrolyte imbalance caused by acute diarrhea. Despite of WHO recommendations on the use of ORS and zinc in the management of acute diarrhea as a simple and effective treatment, the prescribing trend of ORS and zinc in acute diarrhoea is not up to the mark, which further increases the burden of the problems. Objectives: we aimed to assess; (1) prescribing trend of ORS and zinc in acute diarrhoea in children aged 6months to 5years by health care providers, (2) to asses’ proportion of patient education in acute diarrhea by health care providers.Methods: This was a qualitative, cross-sectional, hospital based study carried among children aged 6months to 5yrs.Results: This study was conducted among 313 children of acute diarrhoea who had been treated outside. Mean age (months) was 27.53±15.87. Out of all children who were treated from outside, 180 (57.50%) took treatment from general physician, 113 (36.10%) children took the treatment from pediatrician, and 20 (6.85%) took the treatment from the physician and 25 (7.9%) took treatment as over the counter antidiarrheal by the pharmacists. Out of them dehydration was documented only in 97 (30.99%), while ORS was given in 229 (73.16%) and zinc was given in 121 (38.65%) children. Patients education was done in 39 (12.46%).Conclusions: There was gross under implementation of treatment guidelines in the management of acute diarrhea by health care providers especially by general physicians

Effect of rhizospheric nutrient management on root growth, yield, and nutrient use efficiency of wheat (Triticum aestivum L.) under Tarai region of Uttarakhand, India

Rhizospheric nutrient management and fertilizer placement can be a useful measure to improve wheat crops productivity in Tarai regions of India.  An experiment was conducted to evaluate the effects of rhizospheric nutrient management on wheat (Triticum aestivum L.) to explore the relationship between root proliferation, grain yield and NUE in Tarai region of Uttarakhand,  India.  It comprised 3 fertilizer application (P1 to P3) and 6 nutrient management treatments (T1 to T6) with absolute control in a randomized complete block design and replicated thrice. Experimental results indicated that P1 (1.29 and 1.47; 1.84 and 2.29 mg/cc) produced greater root density, and compared to P3 (1.39 and 1.49; 1.74 and 2.17 mg/cc), P2 (1.24 and 1.36; 1.68 and 1.97 mg/cc) and absolute control (0.85 and 1.19; 1.42 and 1.69 mg/cc) at maximum tillering and flowering stage in year 2017-18 and 2018-19, respectively .The root proliferation also influenced the grain yield (5.4 and 5.5; 5.3 and 5.3; 5.1 and 5.2; 3.5 and 3.3 t/ha ) in P1, P3, P2 and absolute control in the year 2017-18 and 2018-19, respectively.  However, the grain yield and root distributions (at the flowering stage) recorded significantly (p=0.05) maximum in T4 (5.8 and 5.7 t/ha; 1.84 and 2.32 mg/cc) followed by T3, T6, T1, T5, T2 treatments and minimum in absolute control (3.5 and3.3 t/ha; 1.42 and 1.69 mg /cc) in the year of 2017-18 and 2018-19, respectively.  Thus, the rhizospheric nutrient management (75% RDF+ vermicompost + PSB) with fertilizer placement can be a feasible approach for increasing grain yield and NUE in Tarai regions of Uttarakhand, by promoting deep root development and reducing fertilizer inputs in wheat.

Development and validation of a robust high-performance thin layer chromatographic (HPTLC) method for the analysis of Lovastatin in Higher Basidiomycetous mushrooms

Hypercholesteromia is one of the main risk factors of cardiovascular disease, causing high blood pressure and atherosclerosis. This has necessitated development of methods or substances which would reduce cholesterol uptake from the digestive tract or destroy cholesterol by enzymatic reactions. One of the practical approaches to protect the human body from high cholesterol levels is to inhibit the cholesterol-synthesizing ability of the organism. Lovastatin is a metabolite of mold fungi from the different genera. However, its presence has also been detected in fruiting bodies and submerged cultivated mycelia of some species of Higher Basidiomycetous fungus, especially in the species of genus Pleurotus – P. ostreatus and P. eryngii. We are screening Higher Basidiomycetous mushrooms for identification of commercially recoverable quantities of lovastatin.  Since lovastatin quantification in a large number of fungal samples is required, a simple, rapid and accurate analytical method was required. Use of HPTLC for quantitative measurements of lovastatin in fungal biomass has not yet been reported. In the present study a simple, precise, specific and accurate TLC Densitometric method for estimation of lovastatin in Higher Basidiomycetous mushrooms was developed, validated and used for estimation of lovastatin content in the cultured mycelia of Pleurotus spp. The develop method was validated for linearity, accuracy, precision, LOD, LOQ, spiking, robustness as per the ICH guidelines. The Rf and % recovery value for Lovastatin 0.52 and 99.15 respectively. Developed analytical methods showed good separation and recovery of Lovastatin

Efficacy and safety of hydroxychloroquine when added to stable insulin therapy in combination with metformin and glimepiride in patients with type 2 diabetes compare to sitagliptin

Background: The trial was done to evaluate the efficacy and tolerability of hydroxychloroquine when added to stable insulin therapy in combination with metformin and glimepiride in patients with type 2 diabetes (T2DM) compare to sitagliptin.Methods: After two weeks run in period, eligible patients inadequately controlled on long acting, intermediate acting or premixed insulin (HbA1c ≥7.5% and ≤10%), in combination with metformin and glimepiride were randomised 1:1 to the addition of once daily hydroxychloroquine 400mg or sitagliptin 100mg over 24weeks study period. The primary endpoint was HbA1c change from baseline at week 24. Home based glucometer was used to determine finger stick glucose value to detect hypo or hyperglycemia periodically.Results: At 24 weeks, the addition of hydroxychloroquine significantly (p <0.001) reduced HbA1c by 1.3% compared with Sitagliptin which was 0.9%. A greater proportion of patients achieved an HbA1c level <7% while randomised to Hydroxychloroquine as compared with sitagliptin (31 vs. 18% respectively; p <0.001). The addition of hydroxychloroquine significantly (p<0.001) reduced fasting plasma glucose by 31.0mg/dl (vs 23.2mg/dl with sitagliptin) and post prandial plasma glucose by 52.1mg/dl (vs 41mg/dl with sitagliptin) relative to sitagliptin. The difference in mean value of total daily insulin dose showed a highly significant decrease (P <0.0001) from baseline to end of the treatment with hydroxychloroquine i.e. from 41±10.2 to 31.87±16.49 IU as compare to sitagliptin i.e. from 41±10.6 to 37.91±11.71 IU. And also highly significant (P <0.0001) decrease in mean weight was observed at the end of trial with hydroxychloroquine.Conclusions: Hydroxychloroquine decreases HbA1c in patients whose type 2 diabetes is poorly controlled with stable-dose insulin therapy with metformin and glimepiride