Controlling the evolution in modern theory and practice of domestic enterprises management

The aim of the article. The purpose of work is analysis of existent controlling conceptions through the prism of their application in domestic enterprises practical activity.The results of the analysis. In the article on the basis of comparative analysis the estimation of differences is carried out between the conceptual going near determination of essence, place and role of controlling, in the modern terms of domestic economy transformation. Parameters and descriptions of key elements of controlling conception are certain by a gnosiological analysis. The conceptual directions list of controlling development is in-process extended. Attention is accented on the increase of decentralization role and self-government in the modern management system. A place and role of controlling in a modern management is specified. The concept controlling, as interfunctional direction of administrative activity and instrument of unifying management function got subsequent development.Conclusions and directions of further researches. Bases on offered theoretic-methodological positions it can be developed the algorithm of management system improvement with the use of controlling subsection which provides continuous enterprise development

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10-14), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10-8) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10-8). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10-9), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk. © 2015 Nature America, Inc. All rights reserved