Towards an architecture for real-time event processing

The purpose of this paper is to illustrate how and why we have evolved our data processing systems; from an initial version that relied on traditional RDBMSs and batch processing towards a system that processes a constant stream of data.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Towards an architecture for real-time event processing

The purpose of this paper is to illustrate how and why we have evolved our data processing systems; from an initial version that relied on traditional RDBMSs and batch processing towards a system that processes a constant stream of data.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Una plataforma de Real Time Bidding escalable e inteligente

El trabajo busca describir las tecnolog as, procesos y algoritmos aplicados para construir la plataforma de real-time bidding de Jampp y c omo se pretende evolucionar la misma.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Una plataforma de Real Time Bidding escalable e inteligente

El trabajo busca describir las tecnolog as, procesos y algoritmos aplicados para construir la plataforma de real-time bidding de Jampp y c omo se pretende evolucionar la misma.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Una plataforma de Real Time Bidding escalable e inteligente

El trabajo busca describir las tecnolog as, procesos y algoritmos aplicados para construir la plataforma de real-time bidding de Jampp y c omo se pretende evolucionar la misma.Sociedad Argentina de Informática e Investigación Operativa (SADIO

ELECTRON: An Architectural Framework for Securing the Smart Electrical Grid with Federated Detection, Dynamic Risk Assessment and Self-Healing

The electrical grid has significantly evolved over the years, thus creating a smart paradigm, which is well known as the smart electrical grid. However, this evolution creates critical cybersecurity risks due to the vulnerable nature of the industrial systems and the involvement of new technologies. Therefore, in this paper, the ELECTRON architecture is presented as an integrated platform to detect, mitigate and prevent potential cyberthreats timely. ELECTRON combines both cybersecurity and energy defence mechanisms in a collaborative way. The key aspects of ELECTRON are (a) dynamic risk assessment, (b) asset certification, (c) federated intrusion detection and correlation, (d) Software Defined Networking (SDN) mitigation, (e) proactive islanding and (f) cybersecurity training and certification

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p &lt; 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Comment on the article "Symptomatic carotid near-occlusion causes a high risk of recurrent ipsilateral ischemic stroke" by Gu et al.

We read with great interest the recent article “Symptomatic carotid near-occlusion causes a high risk of recurrent ipsilateral ischemic stroke” by Gu et al. [1]. The authors present a single-centre retrospective study in which they describe a preoperative or 90-day ipsilateral ischemic stroke risk that reaches 22% in patients with carotid near-occlusion (CNO) without full collapse and 30% for CNO with full collapse. The risk for CNO exceeds even that observed for “conventional” ≥ 50% carotid stenosis. These results are striking and, if confirmed, could lead to a significant change in the management of patients with symptomatic carotid near-occlusion [2]