Empleo de morteros estructurales eco-eficientes. Revisión crítica desde un análisis DAFO.

One of the main climate trigger are CO2 emissions. In the field of architecture and construction, one of the most harmful materials is the cement due to its employment and its polluting power (about 5 and 8% of the worldwide CO2 emissions). Thus, the search of an alternative material is essential. This paper shows the possibility of using eco-efficient mortars as structural materials, in order to guarantee both safety and environment preservation in the strengthening/refurbishment/retrofitting of structures. In those mortars, the binder can be substituted by organic or inorganic materials (e.g. fly ash, ground granulated blast furnace slag, rice husk ash, palm oil fuel ash). From this strategy, the waste reduction is promoted, as wastes are immobilised without polluting the environment essential. Thus, it is encouraged the re-use of architecture which is an essential factor to get a more sustainable habitat. The obtained results allow setting a guide that makes easier the selection of eco-efficient mortars (guaranteeing both structural safety and environment preservation) to the agents involved in processes of structural works.Uno de los principales detonantes del cambio climático son las emisiones de CO2. En el ámbito de la arquitectura y la construcción, uno de los materiales más perjudiciales en relación a su uso y su poder contaminante es el cemento (entre el 5 y 8% de las emisiones de CO2 en el mundo son generadas por éste). Por tanto, es fundamental buscar alternativas a su uso. Esta investigación muestra la posibilidad del uso de morteros eco-eficientes como materiales estructurales que garanticen tanto la seguridad de la construcción como la preservación del medioambiente en intervenciones de refuerzo/ rehabilitación/consolidación estructural. En estos morteros, el conglomerante o bien es un material distinto al cemento o se realiza la sustitución de parte de éste por materiales orgánicos o inorgánicos como cenizas volantes, residuos de altos hornos, cáscaras de arroz, cenizas de aceite de palma, entre otros, con lo que también se propiciaría la reducción de residuos que pasarían a inmovilizarse sin contaminar la naturaleza. Así, se fomenta el reciclaje de la arquitectura, siendo éste un factor clave para un hábitat sostenible. Los resultados obtenidos permiten establecer una guía que facilite a los agentes implicados en las actuaciones de intervención estructural la selección de morteros eco-eficientes óptimos, tanto para garantizar la seguridad como para preservar el medioambiente

Preliminary feasibility of near-infrared spectroscopy to authenticate grazing in dairy goats through milk and faeces analysis

Nowadays, society demands certification and authentication methodologies that are able to clarify the origin of different livestock products. This is considered of paramount importance in order to not only provide accurate information to consumers, but also to protect producers against fraudulent practices. In this context, the aim of this study is to establish a methodology to authenticate the grazing activity of dairy goats. To achieve this, milk and faeces samples were analysed using Near-Infrared Spectroscopy. The good results obtained in discriminant models demonstrated differences in both types of matrices when the two feeding regimes were compared. The development of this methodology could extend its use not only in dairy systems of goats but also in other animal species and systems

LINK-B: study protocol of a retrospective and prospective project for identification and linkage to care of people living with hepatitis B in a large health area of Barcelona

Hepatology; Telemedicine; VirologiaHepatologia; Telemedicina; VirologiaHepatología; Telemedicina; VirologíaIntroduction An estimated 290 million people are living with hepatitis B virus (HBV) worldwide; in Spain, the prevalence of hepatitis B virus surface antigen (HBsAg) is 0.4%. In our setting, many HBsAg-positive individuals are not linked to care, which implies a barrier to receiving treatment and controlling the infection. The main objective of this project is to evaluate the performance of a programme designed to achieve appropriate linkage to specialist care of HBsAg-positive individuals, newly tested or previously tested and lost to follow-up. Methods and analysis This is a retrospective and prospective study in which all HBsAg-positive cases recorded in the microbiology database will be identified. The retrospective phase will include cases detected between 2018 and 2020, and the prospective phase will run from January 2021 to June 2022. The project will be carried out in a tertiary university hospital covering the northern health area of Barcelona with a catchment population of 450 000 inhabitants and 16 affiliated primary care centres. The central laboratory detects approximately 1200 HBsAg-positive individuals every year; therefore, we expect to identify around 4000 patients over the duration of the project. The medical records of HBsAg-positive individuals will be consulted to identify and retrieve those who have not been appropriately linked to care. Candidates will be contacted to offer specialist disease assessment and follow-up. A website will be created to provide HBV-related information to primary care physicians, and a mobile phone application will be available to patients to improve the linkage circuits and ensure follow-up continuity. Ethics and dissemination The Vall d’Hebrón Hospital Ethics Committee (PR(AG)201/2021) and the Spanish Agency of Medicines and Medical Devices approved this study. The findings will be disseminated through peer-reviewed publications and conference presentations. This programme could increase the number of HBsAg-positive individuals properly linked to care and achieve better HBV monitoring, which will have a positive impact on WHO’s viral hepatitis elimination goals.This project is supported by Gilead Sciences through the competitive research 'HBV Treat' (protocol number IN-ES-320-6107)

Glicosil hidrolasas de Lactiplantibacillus plantarum WCFS1

Resumen del trabajo presentado a la 15ª Reunión de la Red Española de Bacterias Lácticas: Bacterias Lácticas en Alimentación y Salud. Valencia, 26 y 27 de mayo de 2022.AGL2017-84614-C2-1-R y AGL2017-84614-C2-2-RPeer reviewe

Unraveling the effect of silent, intronic and missense mutations on VWF splicing : contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to the identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7437G>A) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of three mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that four of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease. identifier:02869074

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Proposal of teaching innovation for Philology: program for the inclusion of students in academic research and acquisition of scientific and training experiences

Se busca crear un semillero de investigación para fomentar la producción científica y la participación del alumnado en proyectos de edición permitiendo así a los estudiantes la obtención de resultados efectivos antes de finalizar sus estudios.Depto. de Estudios Ingleses: Lingüística y LiteraturaFac. de FilologíaFALSEsubmitte