Arginase activity and CD3ζ expression after major surgery

Letter.-- et al.The studies from our laboratory were supported by grants from Spanish Ministerio de Economia y Competitividad (SAF2011-30518; and RD12/0036/0065 from Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III, cofunded by the Fondo Europeo de Desarrollo Regional of the European Union), the European Community’s Seventh Framework Programme FP7-2007-2013 (grant HEALTH-F2-2011-256986, PANACREAS), and Junta de Castilla y León (CSI052A11-2 and CSI221A12-2).Peer Reviewe

John G. Lockhart y sus Ancient Spanish Ballads

Se entiende que en la historia de la traducción son necesarias cuatro preguntas que han de ser formuladas y respondidas por este orden: quién traduce, qué traduce, cómo y para qué traduce. Son preguntas a las que no siempre podemos dar respuesta en su totalidad, pero a medida que la historia de la civilización occidental es más próxima a nosotros la tarea se hace menos difícil. En el caso que nos ocupa es menos ardua porque la proximidad temporal nos pone a nuestro alcance la documentación necesaria. Empezaremos por el quién, porque las siguientes tienen así más fácil respuesta. Es de un especial interés ver qué y cómo lo presenta porque así sabremos la finalidad y el propósito que estas traducciones tuvieron en su momento, pues hay dos clases de propósitos, los que se confiesan de forma explícita en los prólogos y los que se infieren, en este caso, de la selección que hizo Lockhart del romancero español y de aquellos aspectos del romancero que más le interesó destaca

Virginia Woolf y su traducción: Los diarios

La primera observación que es necesario hacer al presentar la obra de V. Woolf en español es que en nuestro país su edición no se produce hasta que no comienza la transición política, aunque ya en 1973 se publicara una traducción de The Years al catalán (Els anys). Es a partir de 1977 cuando comienza a publicarse de forma continuada y, hasta donde sabemos, lo hizo por la traducción que hiciera J. L. Borges de Orlando en 1937 y que es histórica. Desde entonces y hasta el momento, la publicación de sus obras ha sido constante. Hay que destacar la labor importantísima de la editorial Lumen, fiel a un único traductor, Andrés Bosch, un especialista en la obra de la autora inglesa. Es este conjunto de obra traducida por la misma persona el que, en teoría, tendría que ser el mejor reflejo de la obra original, ya que el traductor ocasional no es lo deseabl

Arginase as a new concern in blood transfusion

Letter to the editor.-- et al.This work was supported in part from the Junta de Castilla y León (Biomedicine project 2011-2012, and CSI221A12-2), Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III, co-funded by the Fondo Europeo de Desarrollo Regional of the European Union (RD06/0020/1037 and RD12/0036/0065), and the Spanish Ministerio de Economia y Competitividad (SAF2011-30518).Peer Reviewe

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusion

Correspondence.Peer Reviewe

Desenvolupament d’un tractament antiadherent de superfícies de titani per a aplicacions biomèdiques

L’ús d’implants de titani per a traumatologia i odontologia és una pràctica molt estesa actualment. El seu èxit, però, es veu afectat pels casos de infeccions que pateixen. En el cas concret dels implants dentals, el 14% dels implants pateixen infeccions bacterianes i entre el 5 i el 8% presenten infecció bacteriana que desenvolupa una peri-implantitis i una conseqüent pèrdua de l’implant. Per aquest motiu, en els darrers anys s’ha estudiat el desenvolupament de superfícies antibacterianes. En aquest treball s’optimitza un tractament antiadherent per a superfícies de titani amb l’objectiu de minimitzar l’adhesió bacteriana que pugui produir una infecció posterior. S’ha desenvolupat un tractament de la superfície de titani per formar un recobriment amb un polímer antiadherent. S’han estudiat les característiques fisicoquímiques de la superfície que en resulta. També s’ha estudiat la seva biocompatibilitat i capacitat per evitar l’adhesió de proteïnes i bacteris.The use of titanium implants for orthopedic and dental practice is currently widespread. Its success, however, is affected by implant-related infections. In the case of dental implants, 14% of implants suffered bacterial infections and between 5 and 8% have a bacterial infection that develops peri-implantitis and consequent loss of the implant. For this reason, in the recent years the development of antibacterial surfaces has been thoroughly studied. In this paper, a treatment has been optimized for creating antifouling titanium surfaces with the objective to minimize bacterial adhesion that may result in an infection. The titanium surface treatment produces a coating with an antifouling polymer. The physicochemical characteristics of the resulting surface have been studied, as well as the biocompatibility and the ability to prevent the adhesion of proteins and bacteria.Peer Reviewe

HyPer biosensor to monitor intracellular hydrogen peroxide in skeletal muscle cells

[EN] Suplemento de la revista Free Radical Biology and Medicine: HyPer biosensor to monitor intracellular hydrogen peroxide in skeletal muscle cells

Polyethylene glycol pulsed electrodeposition for the development of antifouling coatings on titanium

Titanium dental implants are widely used for the replacement of damaged teeth. However, bacterial infections at the interface between soft tissues and the implant can impair the functionality of the device and lead to failure. In this work, the preparation of an antifouling coating of polyethylene glycol (PEG) on titanium by pulsed electrodeposition was investigated in order to reduce Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) adhesion while maintaining human fibroblast adhesion. Different pulsed conditions were prepared and characterized by contact angle, Focused Ion Beam (FIB), Fourier Transformed Infrared Spectroscopy in the Attenuated Total Reflectance mode (ATR-FTIR), and X-ray photoelectron spectroscopy (XPS). XPS tested fibronectin adsorption. S. aureus, E. coli and human fibroblast adhesion was tested in vitro in both mono and co-culture settings. Physicochemical characterization proved useful for confirming the presence of PEG and evaluating the efficiency of the coating methods. Fibronectin adsorption decreased for all of the conditions, but an adsorption of 20% when compared to titanium was maintained, which supported fibroblast adhesion on the surfaces. In contrast, S. aureus and E. coli attachment on coated surfaces decreased up to 90% vs. control titanium. Co-culture studies with the two bacterial strains and human fibroblasts showed the efficacy of the coatings to allow for eukaryotic cell adhesion, even in the presence of pre-adhered bacteria.Peer ReviewedPostprint (published version

Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats

-acylethanolamines or acylethanolamides. The hydrolysis of OEA and PEA is catalyzed by the fatty acid amide hydrolase (FAAH). A number of FAAH inhibitors that increase the levels of OEA and PEA in the brain have been developed, including URB597. In the present report, we examined whether URB597, OEA or PEA injected into wake-related brain areas, such as lateral hypothalamus (LH) or dorsal raphe nuclei (DRN) would promote wakefulness (W) in rats.Male Wistar rats (250–300 g) were implanted for sleep studies with electrodes to record the electroencephalogram and electromyogram as well as a cannulae aimed either into LH or into DRN. Sleep stages were scored to determine W, slow wave sleep (SWS) and rapid eye movement sleep (REMS). Power spectra bands underly neurophysiological mechanisms of the sleep-wake cycle and provide information about quality rather than quantity of sleep, thus fast Fourier transformation analysis was collected after the pharmacological trials for alpha (for W; α = 8–12 Hz), delta (for SWS; δ = 0.5–4.0 Hz) and theta (for REMS; θ = 6.0–12.0 Hz). Finally, microdialysis samples were collected from a cannula placed into the nucleus accumbens (AcbC) and the levels of dopamine (DA) were determined by HPLC means after the injection of URB597, OEA or PEA. We found that microinjection of compounds (10, 20, 30 µg/1 µL; each) into LH or DRN during the lights-on period increased W and decreased SWS as well as REMS and enhanced DA extracellular levels.URB597, OEA or PEA promoted waking and enhanced DA if injected into LH or DRN. The wake-promoting effects of these compounds could be linked with the enhancement in levels of DA and indirectly mediated by anandamide