Lessons of Election 2000

Many people believe that Election 2000 proved only how divided the nation is over politics and policy. In contrast, this study draws six lessons from Election 2000. Congress should set up a commission to recommend changes in the electoral system; the states should have the choice of accepting the reforms and the obligation to pay for them. The Electoral College should be preserved. The framers designed the Electoral College to limit arbitrary power. Abolishing the Electoral College would weaken the states and damage federalism. The United States is a consitutional republic, not a regime based on "the will of the people." Several politicians have appealed to the will of the people in the Florida struggle. The will of the people is a concept alien to the American political tradition of limited constitutional government. Underlying public attitudes strongly supported limited government in Election 2000. Both the platforms of the candidates and public opinion polls indicate that the public's skepticism about government remains high. Campaign spending enhanced turnout and participation in Election 2000. Both the NAACP and unions spent lavishly on getting out the vote. If campaign spending is restricted, turnout will fall, contrary to the professed desire of advocates of capaign finance restrictions. Congress should not hold hearings about media mistakes. Any punishment for errors or bias by the networks on election night should be left to public opinion

Scaling up a learning technology strategy: Supporting student/faculty teams in learner‐centred design

Many post‐secondary institutions are experiencing the challenge of scaling up their learning technology initiatives without a matching increase in staff resources. This mismatch is particularly acute at the design stage of projects, where both domain knowledge and instructional design expertise are needed. To address this, we are developing structures and tools for a small cadre of instructional design experts to support a growing number of learning technology projects developed by student/faculty teams. One of these tools, the Learner‐Centred Design Idea Kit, is an interactive WWW‐based resource now in a fourth iteration of use in an undergraduate course, Designing Learning Activities with Interactive Multimedia. The course and the LCD Idea Kit which supports it are part of a larger institutional strategy to introduce technology‐enabled change in the learning process, working ‘bottom‐up’ with individual faculty and using the LCD Idea Kit to scale up the course across multiple university departments. In this paper, we describe the course and the Kit in detail and provide and overview of our current status and lessons learned

Globalization, Cosmopolitanism, and Personal Identity

Many critics of increasing freedom of trade and of movement, and the phenomena of cosmopolitanism and globalization that result from such freedom, insist that the consequence of greater trade and movement is a net loss of identity. Globalization is, they allege, destructive of personal identity itself, which they see as reliant on sharply delineated differences among cultures. This paper sets out the anti-globalist critique and then shows that cosmopolitanism and globalization are hardly new phenomena, but have deep roots in European civilization. The threat allegedly posed by globalization to personal identity is described and the arguments of its main proponents given, followed by a critique of the theory of personal identity implicit in the argument and an alternative theory of personal identity (a “focal theory”) is described; that theory is both truer to lived human experience and fully compatible with the securing of personal identity in the context of an increasingly globalized world of free individuals

Estimating structural mean models with multiple instrumental variables using the generalised method of moments

Instrumental variables analysis using genetic markers as instruments is now a widely used technique in epidemiology and biostatistics. As single markers tend to explain only a small proportion of phenotypical variation, there is increasing interest in using multiple genetic markers to obtain more precise estimates of causal parameters. Structural mean models (SMMs) are semi-parametric models that use instrumental variables to identify causal parameters, but there has been little work on using these models with multiple instruments, particularly for multiplicative and logistic SMMs. In this paper, we show how additive, multiplicative and logistic SMMs with multiple discrete instrumental variables can be estimated efficiently using the generalised method of moments (GMM) estimator, how the Hansen J-test can be used to test for model mis-specification, and how standard GMM software routines can be used to fit SMMs. We further show that multiplicative SMMs, like the additive SMM, identify a weighted average of local causal effects if selection is monotonic. We use these methods to reanalyse a study of the relationship between adiposity and hypertension using SMMs with two genetic markers as instruments for adiposity. We find strong effects of adiposity on hypertension, but no evidence of unobserved confounding.

Estimating Structural Mean Models with Multiple Instrumental Variables using the Generalised Method of Moments

Instrumental variables analysis using genetic markers as instruments is now a widely used technique in epidemiology and biostatistics. As single markers tend to explain only a small proportion of phenotypical variation, there is increasing interest in using multiple genetic markers to obtain more precise estimates of causal parameters. Structural mean models (SMMs) are semi-parametric models that use instrumental variables to identify causal parameters, but there has been little work on using these models with multiple instruments, particularly for multiplicative and logistic SMMs. In this paper, we show how additive, multiplicative and logistic SMMs with multiple discrete instrumental variables can be estimated efficiently using the generalised method of moments (GMM) estimator, how the Hansen J-test can be used to test for model mis-specification, and how standard GMM software routines can be used to fit SMMs. We further show that multiplicative SMMs, like the additive SMM, identify a weighted average of local causal effects if selection is monotonic. We use these methods to reanalyse a study of the relationship between adiposity and hypertension using SMMs with two genetic markers as instruments for adiposity. We find strong effects of adiposity on hypertension, but no evidence of unobserved confounding.Structural Mean Models, Multiple Instrumental Variables, Generalised Method of Moments, Mendelian Randomisation, Local Average Treatment Effects

Running a traditional ‘textbook’ campaign, Rob Portman has a commanding lead in Ohio’s Senate race, in spite of Donald Trump.

As part of our series covering key Senate races in the 2016 election, Tom Sutton and Barbara Palmer take a close look at Ohio’s election, where former Governor Ted Strickland is challenging the incumbent Republican Senator Rob Portman. While Portman was initially considered to be vulnerable, he is now nearly 15 percentage points ahead of Strickland, a lead which may be down to the GOP Senator’s superior fundraising and the funding of attack ads by outside campaign groups

Investigation Into the use of C- and N-terminal GFP Fusion Proteins for Subcellular Localization Studies Using Reverse Transfection Microarrays

Reverse transfection microarrays were described recently as a high throughput method for studying gene function. We have investigated the use of this technology for determining the subcellular localization of proteins. Genes encoding 16 proteins with a variety of functions were placed in Gateway expression constructs with 3′ or 5′ green fluorescent protein (GFP) tags. These were then packaged in transfection reagent and spotted robotically onto a glass slide to form a reverse transfection array. HEK293T cells were grown over the surface of the array until confluent and GFP fluorescence visualized by confocal microscopy. All C-terminal fusion proteins localized to cellular compartments in accordance with previous studies and/or bioinformatic predictions. However, less than half of the N-terminal fusion proteins localized correctly. Of those that were not in concordance with the C-terminal tagged proteins, half did not exhibit expression and the remainder had differing subcellular localizations to the C-terminal fusion protein. This data indicates that N-terminal tagging with GFP adversely affects the protein localization in reverse transfection assays, whereas tagging with GFP at the C-terminal is generally better in preserving the localization of the native protein. We discuss these results in the context of developing high-throughput subcellular localization assays based on the reverse transfection array technology

The FX/90: A proposal in response to a low Reynolds Number station keeping mission

The FX/90 is a remotely piloted vehicle designed to fly at Reynolds numbers below 2 x 10 to the 5th power. Several applications exist for this type of flight, such as low altitude flight of very small aircraft. The design presented here allows investigation into the unique problems involved in low Reynolds number flight, which will, in turn, further understanding of this flight regime. The aircraft will operate in a steady flight environment, free from significant atmospheric turbulence and weather effects. The F-90 has a 39 in. fuselage which is constructed of balsa and plywood. The landing gear for the aircraft is a detachable carriage on which the aircraft rests. The aerodynamic planform is a rectangular wing (no taper or sweep) with a chord of 9 in., a wingspan of 72 in., and is constructed entirely out of styrofoam. The propulsion system is a puller configuration mounted on the front of the fuselage. It consists of an Astro 05 engine and a 10-6 two bladed propeller. Control of the aircraft is accomplished through the use of two movable control surfaces: elevators for pitch control, and a rudder for yaw control. The aircraft is soundly constructed, highly maneuverable, and adequately powered. Furthermore, the investigation into alternative technologies, most notably the styrofoam wing and the detachable landing gear, holds promise to improve the performance of the aircraft

Comparison of typical meteorological year and on-site measurements for solar PV site selection

The standard approach when simulating photovoltaic output is to employ Typical Meteorological Year (TMY) data sets. This paper uses statistical analyses to investigate several TMYs. The objectives are: (1) to ascertain which TMY generation method most accurately reproduces solar conditions in the UK; (2) to discover the minimum time resolution at which TMYs delver reliable results; and (3) to determine if there are any circumstances in which TMYs can replace long-term time series