Gingival changes in children taking antiepileptic medication 4 years of clinical evaluation

Os autores efetuaram durante 4 anos a avaliação clínica das Alterações Gengivais em Crianças a fazer medicação anti-epiléptica. Foram seguidas 300 crianças de risco médico acrescido, de ambos os sexos, até aos 12 anos de idade; tomaram como grupo testemunha igual número de crianças saudáveis, da mesma faixa etária. Analisaram a distribuição das crianças consoante o sexo e a idade, em ambos os grupos. Verificaram o número de casos de crianças com epilepsia e a data do diagnóstico, início da terapêutica e ainda o fármaco utilizado. Determinaram a prevalência de hiperplasia gengival nos diferentes grupos e a sua correlação com a medicação, a higiene oral e o tipo de dieta. Fizeram propostas terapêuticas com base na experiência que obtiveram. Concluíram que a hiperplasia gengival se encontra predominantemente associada à Fenitoína e à Primidona; apresenta também uma íntima relação com a deficiente higiene oral e com a dieta mole.The authors have made during four years, the clinicai evaluation of the gingival alterations in the children getting anti-epileptic medication. A follow upof three hundred increased medicai risk children, was done. These children, from both the sexes were aged until twelve. An equal number of healthy children, aging the same range, was considered as testimony group. The distribution of these children was analysed according the sex and the age in both the groups. The number of the cases of children with apilepsy and the time of the diagnosis, the therapeutic beginning and still the used medicine, was verified. The prevalence of gingival hyperplasia at the different groups and its correlations with the medication, the oral hygiene and the type of the diet were recorded. Therapeutical proposals based on the obtained experience were advanced. The authors have concluded that the gingival hyperplasia is mainly associated to Phenytoin and Primidone and has also a dose connection with the poor oral hygiene and the soft diet

Analysis of cervical node metastasis in oral cavity squamous cell carcinoma patients

Analysis of cervical node metastasis in oral cavity squamous cell carcinoma patientsN/

Pretreatment hemoglobin level as a prognostic factor in patients with locally advanced head and neck squamous cell carcinoma

AimEvaluate pretreatment hemoglobin values as a prognostic factor in patients with locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy.BackgroundAnemia is one of the most prevalent laboratory abnormalities in oncological disease. It leads to a decrease in cellular oxygen supply, altering radiosensitivity of tumor cells and compromising therapeutic outcomes.Materials and MethodsRetrospective evaluation of patients with HNSCC treated with cCRT. Primary and secondary endpoint was to evaluate the correlation of Hb levels (≥12.5g/dL o

Alterações gengivais em crianças a efetuar medicação anti-epiléptica 4 anos de avaliação clínica

The authors have made during four years, the clinicai evaluation of the gingival alterations in the children getting anti-epileptic medication. A follow upof three hundred increased medicai risk children, was done. These children, from both the sexes were aged until twelve. An equal number of healthy children, aging the same range, was considered as testimony group. The distribution of these children was analysed according the sex and the age in both the groups. The number of the cases of children with apilepsy and the time of the diagnosis, the therapeutic beginning and still the used medicine, was verified. The prevalence of gingival hyperplasia at the different groups and its correlations with the medication, the oral hygiene and the type of the diet were recorded. Therapeutical proposals based on the obtained experience were advanced. The authors have concluded that the gingival hyperplasia is mainly associated to Phenytoin and Primidone and has also a dose connection with the poor oral hygiene and the soft diet.Os autores efetuaram durante 4 anos a avaliação clínica das Alterações Gengivais em Crianças a fazer medicação anti-epiléptica. Foram seguidas 300 crianças de risco médico acrescido, de ambos os sexos, até aos 12 anos de idade; tomaram como grupo testemunha igual número de crianças saudáveis, da mesma faixa etária. Analisaram a distribuição das crianças consoante o sexo e a idade, em ambos os grupos. Verificaram o número de casos de crianças com epilepsia e a data do diagnóstico, início da terapêutica e ainda o fármaco utilizado. Determinaram a prevalência de hiperplasia gengival nos diferentes grupos e a sua correlação com a medicação, a higiene oral e o tipo de dieta. Fizeram propostas terapêuticas com base na experiência que obtiveram. Concluíram que a hiperplasia gengival se encontra predominantemente associada à Fenitoína e à Primidona; apresenta também uma íntima relação com a deficiente higiene oral e com a dieta mole

Relevant factors for treatment outcome and time to healing in medication-related osteonecrosis of the jaws – A retrospective cohort study

Background: Risk factors for medication-related osteonecrosis of the jaw (MRONJ) are well known, although few studies evaluate the factors that influence treatment outcomes in MRONJ and whether discontinuing antiresorptive medication influences healing. Purpose: (1) Describe the characteristics of a population of patients with MRONJ. (2) Identify the factors associated with favourable outcomes. (3) Identify a temporal correlation between discontinuation of antiresorptives and healing time. Methods: A retrospective longitudinal cohort study was carried out, including 77 patients with MRONJ treated between 2004 and 2016. Primary outcome was defined as healed/improved vs. worse/stable. Time to healing was set as the secondary outcome. Statistical significance was defined as p < 0.05. Results: Primary disease, route of administration, lesion location, and development of complications influenced the outcome of treatment. Significant differences in outcomes according to primary disease (p < 0.05) were found when staging, gender, and lesion location were held constant. Time to healing was longer for patients who discontinued medication more than 3 months after diagnosis than for those who discontinued at diagnosis or before - respectively, 36, 9, and 7 months (p = 0.01). Conclusions: The outcome of MRONJ treatment may be influenced by primary disease and route of administration of antiresorptives. Antiresorptive medication discontinuation contributes to reduce healing time in MRONJ.info:eu-repo/semantics/publishedVersio

Analysis of cervical node metastasis in oral cavity squamous cell carcinoma patients retrospective study and literature comparison

Background/Objective: Oral Cavity Cancer is a frequent type of Head and Neck Cancer, associated with high mortality rates worldwide. One of the main prognostic factors for the disease is regional lymph node metastasis that is associated with survival rate reduction by 50%. Reported tumour sites more frequently associated with regional node metastasis vary throughout literature. Therefore, we aimed to conduct a retrospective study that would allow us to identify the relationship between patient and SCC tumour factors with the rate of neck metastasis and compare our data with the conclusions from similar studies. Methods: A retrospective study was conducted in the Oral Medicine and Oncology Consultation of the Stomatology Department from Centro Hospitalar Universitário Lisboa Norte, comprehending patients diagnosed with Squamous Cell Carcinoma between January 2015 and April 2021. As eligibility criteria we considered patients which had clinical charts with complete information including sociodemographic variables, tumour site and disease staging at diagnosis. We excluded tumour sites with only two diagnosed cases, considering bias risk. Three groups were defined according to a clinical/pathological reason. The current research was approved by an independent ethics committee. Results: The sample includes 151 cases, the majority of which were males (≈59%) and with average age at diagnosis (± standard deviation) of 65 ± 13 years-old. Oral tumour sites with highest percentage of cases with clinical positive lymph nodes (cN+) by the time of diagnosis were inferior gingiva (72.7%, n=16), mouth floor (66.7%, n=22), oropharynx (64.7%, n=11), retromolar trigone (58%, n=11) and ventral tongue (57%, n=16). Sites with fewer cases of cN+ were inferior lip (31%, n=4) and superior lip (n=0). Similar results were found in our sample when operated tumors (pN+) were considered: floor of the mouth (65%, n=13), retromolar trigone (63.6%, n=7), inferior gingiva (46.2%, n=6) and ventral tongue (45%, n=9). Tumour sites with fewer pN+ cases were hard palate (25%, n=1), superior gingiva (16.7%, n=1) and inferior lip (0 out of 7 cases). According to Fisher’s exact test there is no statistically significant association (p-value=0.1506) between primary tumour site and cervical node disease (either cN+ or, whenever available, pN+). Conclusions: Our data seem to indicate an association between primary tumour site and N+, being cervical metastasis more frequent when tumour site was posterior and caudally located. Lower lip had the fewer positive lymph nodes, probably correlated with the inclusion in the same group of oral mucosa and skin cancers. Despite these findings, the association was not statistically significant.info:eu-repo/semantics/publishedVersio