Analysis of cervical node metastasis in oral cavity squamous cell carcinoma patientsN/

Caldas, Cecília

Coutinho, Gonçalo Cunha

Coutinho, José Cunha

Domingues, Tiago

Nobre, Miguel Araújo

Palmela, Paulo

Salvado, Francisco

Silva, Leonor Cruz e

São João, Ricardo

English

Repositório Cientifico do Instituto Politécnico de Santarém

ANALYSIS OF CERVICAL NODE METASTASIS IN ORAL CAVITY SQUAMOUS CELL CARCINOMA PATIENTSLeonor Cruz e Silva1;José Cunha Coutinho 1; Gonçalo Cunha Coutinho 1; Ricardo São João2,3; Tiago Domingues 2; Cecília Caldas 1; Paulo Palmela 1; Miguel Araújo Nobre4,5; Francisco Salvado 1,41 Stomatology University Clinic, Centro Hospital Universitário Lisboa Norte; 2 Department of ComputerScience and Quantitative Methods, School of Management and Technology-Polytechnic Institute ofSantarém; 3 CEAUL, Faculdade de Ciências, Universidade de Lisboa; 4 Faculdade de Medicina da Universidade de Lisboa; 5 Maló ClinicINTRODUCTIONORAL CAVITY CANCERBuccalMucosaFloor ofthe MouthAnterior TongueAlveolar RidgesRetromolarTrigoneHard PalateInner Partof the Lips• Sixteenth position worldwide• Squamous Cell Carcinoma accounts for more than 90% of casesALCOHOOL - TOBACCODeleterious chewing habitsORAL CAVITY CANCERPRESENCE OF LYMPHATIC METASTASIS IS THOUGHT TO BE THE MOST RELEVANT PROGNOSTIC FACTORTumour Staging 5-year survical rateLocalized disease - stages I and II 80%Locorregional disease - stages III, IVA and IVB 50%Distant disease - stage IVC 25%OVERALL SURVIVAL 40-50%ORAL CAVITY CANCERDissemination behaviour may be influenced by barriers tumour encountersDifferent manifestations of oral cancer. Images from the Stomatology University Department of Centro Hospital Universitário Lisboa Norte - MultimediaArchiveORAL CAVITY CANCERTherapeutic management of clinically node negative neck is defined by calculated risk ofoccult metastases or undetectable micro metastases, and primary subsite of cancer lesionmay play a relevant role in this estimates. METHODSMETHODSRETROSPECTIVE STUDY IN ORAL MEDICINE AND ONCOLOGY UNITY OF THE STOMATOLOGY DEPARTMENT OF CENTRO HOSPITALAR UNIVERSITÁRIO LISBOA NORTEPatients diagnosed with Oral cavity Squamous Cell Carcinoma (OSCC) January 2015 – April 2021Inclusion criteria: clinical charts with complete information Exclusion criteria: clinical charts with incomplete information A convenience sample was considered and only patient charts were consulted, with personal data completelyanonymised - informed consent was not collected.METHODSTHREE GROUPS WERE DEFINED FOR ANALYSIS:• Anterior Region - Upper Maxilla: upper lip,  maxillary gingiva and alveolar ridge, upper vestibule, jugal mucosa, hard palate• Anterior Region - Lower Jaw: lower lip, lingual border, lingual dorsum, lingual belly, floor of the mouth, mandibular gingiva and alveolar ridge, lower vestibule• Posterior Region: retromolar trigone, oropharynxRESULTSRESULTS17,08%67,92%15,00%0,00%10,00%20,00%30,00%40,00%50,00%60,00%70,00%Tumour Sitesanterior region - upper maxilla anterior region - lower jaw posterior regionThe proportions of primary tumor location with cervical metastization were found to be distinct (Chi-square test for proportions, p-value<0.001)Most patients are male, sexagenarian, smokers and drinkers.87 (57,6%)64 (42,4%)RESULTS↑Oral tumour sites with highest % of cases with clinical positivelymph nodes (cN+) by the time of diagnosis were inferior gingiva(72.7%, n=16), mouth floor (66.7%, n=22), oropharynx (64.7%,n=11), retromolar trigone (58%, n=11) and ventral tongue (57%,n=16).↓Sites with fewer cases of cN+ were inferior lip (31%, n=4) andsuperior lip (n=0).Similar results were found in our sample when operated tumors(pN+) were considered. Tumour sites with fewer pN+ cases werehard palate (25%, n=1), superior gingiva (16.7%, n=1) and inferiorlip (0 out of 7 cases).According to Fisher’s exact test there is no statistically significantassociation (p-value=0.1506) between primary tumour site andcervical node disease (either cN+ or, whenever available, pN+)C O N C L U S I O N S / D I S C U S S I O NPossible association between primary tumour site and involved lymph nodes• In accordance to similar studiesAssociation was not statistically significantFurther studies in this field are requiredACKNOWLEDGEMENTSThis study is partially financed by national funds through FCT Fundação para a Ciência e Tecnologia under the project UIDB/ 00006/2020.A special acknowledgement to Stomatology University Department of CentroHospitalar Universitário Lisboa Norte for the support and data provided.REFERENCES• Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, et al. 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Dermatol Surg. abril de2017;43(4):494-506. https://doi.org/10.1097/ DSS.0000000000001020ANALYSIS OF CERVICAL NODE METASTASIS IN ORAL CAVITY SQUAMOUS CELL CARCINOMA PATIENTSTHANK YOUR FOR YOURPPA: PRESENCE, PARTICIPATION & ATTENTION !Any questions?leonormcruzesilva@hotmail.com

Analysis of cervical node metastasis in oral cavity squamous cell carcinoma patients

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Analysis of cervical node metastasis in oral cavity squamous cell carcinoma patients

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