Generalized Fast-Convolution-based Filtered-OFDM: Techniques and Application to 5G New Radio

This paper proposes a generalized model and methods for fast-convolution (FC)-based waveform generation and processing with specific applications to fifth generation new radio (5G-NR). Following the progress of 5G-NR standardization in 3rd generation partnership project (3GPP), the main focus is on subband-filtered cyclic prefix (CP) orthogonal frequency-division multiplexing (OFDM) processing with specific emphasis on spectrally well localized transmitter processing. Subband filtering is able to suppress the interference leakage between adjacent subbands, thus supporting different numerologies for so-called bandwidth parts as well as asynchronous multiple access. The proposed generalized FC scheme effectively combines overlapped block processing with time- and frequency-domain windowing to provide highly selective subband filtering with very low intrinsic interference level. Jointly optimized multi-window designs with different allocation sizes and design parameters are compared in terms of interference levels and implementation complexity. The proposed methods are shown to clearly outperform the existing state-of-the-art windowing and filtering-based methods.Comment: To appear in IEEE Transactions on Signal Processin

Frequency-Domain Signal Processing for Spectrally-Enhanced CP-OFDM Waveforms in 5G New Radio

Orthogonal frequency-division multiplexing (OFDM) has been selected as the basis for the fifth-generation new radio (5G-NR) waveform developments. However, effective signal processing tools are needed for enhancing the OFDM spectrum in various advanced transmission scenarios. In earlier work, we have shown that fast-convolution (FC) processing is a very flexible and efficient tool for filtered-OFDM signal generation and receiver-side subband filtering, e.g., for the mixed-numerology scenarios of the 5G-NR. FC filtering approximates linear convolution through effective fast Fourier transform (FFT)-based circular convolutions using partly overlapping processing blocks. However, with the continuous overlap-and-save and overlap-and-add processing models with fixed block-size and fixed overlap, the FC-processing blocks cannot be aligned with all OFDM symbols of a transmission frame. Furthermore, 5G-NR numerology does not allow to use transform lengths shorter than 128 because this would lead to non-integer cyclic prefix (CP) lengths. In this article, we present new FC-processing schemes which solve the mentioned limitations. These schemes are based on dynamically adjusting the overlap periods and extrapolating the CP samples, which make it possible to align the FC blocks with each OFDM symbol, even in case of variable CP lengths. This reduces complexity and latency, e.g., in mini-slot transmissions and, as an example, allows to use 16-point transforms in case of a 12-subcarrier-wide subband allocation, greatly reducing the implementation complexity. On the receiver side, the proposed scheme makes it possible to effectively combine cascaded inverse and forward FFT units in FC-filtered OFDM processing. Transform decomposition is used to simplify these computations. Very extensive set of numerical results is also provided, in terms of radio-link performance and associated processing complexity.Comment: This work has been submitted to the IEEE Transactions on Wireless Communications for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessibl

Flexible fast-convolution processing for cellular radio evolution

Orthogonal frequency-division multiplexing (OFDM) has been selected as a baseline waveform for long-term evolution (LTE) and fifth-generation new radio (5G NR). Fast-convolution (FC)-based frequency-domain signal processing has been recently considered as an effective tool for transmitter and receiver side subband filtering of OFDM-based waveforms. However, for the original continuous FC-based model, the filtering can, in general, be configured in time-direction only with the granularity of half subframe, corresponding to 7, 14, or 28 symbols with 15 kHz, 30 kHz, or 60 kHz subcarrier spacing, respectively. In this paper, we present a symbol-synchronous FC-processing scheme flexibly allowing filter re-configuration with the time resolution equal to one OFDM symbol while supporting tight carrier-wise filtering for 5G NR in mixed-numerology scenarios with adjustable subcarrier spacings, center frequencies, and subband bandwidths, as well as providing co-existence with LTE. Proposed approach segments each stream of time-domain OFDM symbols into overlapping processing blocks of fixed size. Symbol synchronous processing is achieved by dynamically adjusting the overlap between the processing blocks while aligning the payload part of the processing block with the boundaries of the OFDM symbols. The proposed scheme is demonstrated to support the envisioned use cases of 5G NR and provide a flexible starting point for sixth generation (6G) development.acceptedVersionPeer reviewe

Exploiting bluetooth vulnerabilities in e-health IoT devices

Internet of Things (IoT) is an interconnected network of heterogeneous things through the Internet. The current and next generation of e-health systems are dependent on IoT devices such as wireless medical sensors. One of the most important applications of IoT devices in the medical field is the usage of these smart devices for emergency healthcare. In the current interconnected world, Bluetooth Technology plays a vital role in communication due to its less resource consumption which suits the IoT architecture and design. However Bluetooth technology does not come without security flaws. In this article, we explore various security threats in Bluetooth communication for e-Health systems and present some examples of the attacks that have been performed on e-Health systems by exploiting the identified vulnerabilities - 2019 Association for Computing Machinery.This publication was made possible by NPRP grant NPRP10-0125-170250 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors.Scopu

Software-defined radio prototype for fast-convolution-based filtered OFDM in 5G NR

In this work, we provide first-in-class measurement results for fast-convolution-based filtered orthogonal frequencydivision multiplexing (FC-F-OFDM) processing implemented on a universal software radio peripheral (USRP) software-defined radio (SDR). The fast-convolution-based processing offers a highly efficient and flexible filtered OFDM scheme allowing to achieve high spectral utilization in different channel bandwidths. Through the SDR implementation and transmitter spectrum emission measurements, we show that FC-F-OFDM allows to increase spectrum utilization compared to the fifth generation new radio (5G NR) Release-15 requirements. Furthermore, considering the out-of-band emission masks and adjacent-channel-leakage-ratio requirements, FC-F-OFDM provides a larger interference margin than well-known windowed overlap-and-add OFDM processing.acceptedVersionPeer reviewe

SDR Prototype for Clipped and Fast-Convolution Filtered OFDM for 5G New Radio Uplink

In wireless communications, higher transmission power enables higher coverage or higher data rate. However, due to hardware limitations, achieving high power efficiency becomes challenging. The main issue is that at high power region close to power amplifier (PA) saturation point the highly non-linear response of the PA leads to significant spectral regrowth. In such a case, waveforms with inherently good spectral containment allow for more spectral degradation and can be seen as the most effective solution for the problem. In this study, a fifth-generation new radio (5G NR) user equipment (UE) transmit power is improved by utilizing fast-convolution filtered orthogonal-frequency-division-multiplexing (FC-F-OFDM) waveform, which has an excellent spectral containment performance. A novel method is proposed for improving the peak-to-average-power ratio (PAPR) of FC-F-OFDM waveform, based on applying clipping before FC processing and allocating the clipping noise that stems from the applied clipping, over not only on active band, but a wider band consisting of both the in-band and guard-band regions. An accurate transmitter chain simulator including a measured memory-polynomial model of a practical PA is used to evaluate a wide set of different subcarrier spacings and channel bandwidths. Then, to validate the numerical results, a software-defined radio (SDR) based testbed is created and the modeled PA is used in this testbed. Weighted overlap-and-add (WOLA) based OFDM, also with clipping, is used as a reference in both the numerical evaluations and in measurements. For both waveforms, the transmitted signal quality, out-of-band emissions, and maximum PA output powers are measured under 5G NR specifications and results for different subcarrier spacings and channel bandwidths are provided to prove the benefits and robustness of the presented FC-F-OFDM approach.publishedVersionPeer reviewe

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.Peer reviewe

Sleep apnoea is a risk factor for severe COVID-19

Background Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19.Methods OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies.Results We identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021).Conclusion Risk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Abstract Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD