105 research outputs found
Between conservation and disappearance : wine producers and heritage In areas of rural-urban interaction in Mendoza
Fil: Scoones, Ana.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Torres, Laura.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Pastor, Gabriela.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Acosta, Gabriela.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Palazzo, Romina.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Torres, Rocío.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Dubini, Daniela.
Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Palazzo, Elena.
Instituto Argentino de Investigaciones de las Zonas Áridas <IADIZA
Willage: A Two-Tiered Peer-to-Peer Resource Sharing Platform for Wireless Mesh Community Networks
The success of experiences such as Seattle and Houston Wireless has attracted the attention on the so called wireless mesh community networks. These are wireless multihop networks spontaneously deployed by users willing to share communication resources. Due to the community spirit characterizing such networks, it is likely that users will be willing to share other resources besides communication resources, such as data, images, music, movies, disk quotas for distributed backup, and so on. In other words, it is expected that peer-to-peer applications will be deployed in such type of networks. In this paper we propose Willage, a platform for resource localization in wireless mesh community networks with mobile users. The platform is based on a two-tiered architecture: resources are made available at the lower tier, which is composed of mobile terminals, whereas information on their localization is managed at the upper layer, which is composed of wireless mesh routers. We also introduce Georoy, an algorithm for the efficient retrieval of the information on resource localization based on the Viceroy algorithm. Simulation results show that Willage achieves its goal of enabling efficient and scalable peer-to-peer resource sharing in wireless mesh community networks
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell carcinomas that were diagnosed in female patients (mean age: 53.4 years; range: 31-69 years). Based on our findings, we conclude that the majority of clear cell carcinomas are ER/PR positive and consequently amenable to anti-ER treatment modalities. A subset of clear cell carcinomas also harbored alterations in PIK3CA/PTEN/AKT pathway, particularly PTEN, indicating a potential benefit of PI3K/Akt/mTOR inhibitors. The status of I-O biomarkers in clear cell carcinomas indicates a limited therapeutic benefit of immune checkpoint inhibitors (against PD-1/PD-L1)
Coupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma
A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell renal cell carcinoma (ccRCC) stages I, II, III, and IV (n = 112) and controls (n = 52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry and machine learning techniques. Multivariate models based on support vector machines and the LASSO variable selection method yielded two discriminant lipid panels for ccRCC detection and early diagnosis. A 16-lipid panel allowed discriminating ccRCC patients from controls with 95.7% accuracy in a training set under cross-validation and 77.1% accuracy in an independent test set. A second model trained to discriminate early (I and II) from late (III and IV) stage ccRCC yielded a panel of 26 compounds that classified stage I patients from an independent test set with 82.1% accuracy. Thirteen species, including cholic acid, undecylenic acid, lauric acid, LPC(16:0/0:0), and PC(18:2/18:2), identified with level 1 exhibited significantly lower levels in samples from ccRCC patients compared to controls. Moreover, 3α-hydroxy-5α-androstan-17-one 3-sulfate, cis-5-dodecenoic acid, arachidonic acid, cis-13-docosenoic acid, PI(16:0/18:1), PC(16:0/18:2), and PC(O-16:0/20:4) contributed to discriminate early from late ccRCC stage patients. The results are auspicious for early ccRCC diagnosis after validation of the panels in larger and different cohorts.Fil: Manzi, Malena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Palazzo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Knott, María Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Beauseroy, Pierre. Université de Technologie de Troyes; FranciaFil: Yankilevich, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Giménez, María Isabel. Hospital Italiano; ArgentinaFil: Monge, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentin
Poor efficacy of palbociclib in second-line treatment of metastatic lobular breast cancer in a case series: Use before or never more?
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T cells and delayed graft function
Ischemia-reperfusion injury (IRI) in kidney transplantation is the major cause of delayed graft function (DGF), an event associated with an increased risk of acute rejection. The aim of this study was to evaluate T helper (Th) cell phenotype in renal transplants with DGF. T-bet (Th1), GATA-3 (Th2) and IL-17 (Th17) protein expression was investigated in pretransplant biopsies, DGF and acute tubular damage (ATD) caused by calcineurin-inhibitor toxicity. Intracytofluorimetric analysis of IFN-γ, IL-4 and IL-17 was performed to analyze Th1, Th2 and Th17 responses in peripheral blood mononuclear cells of recipients with early graft function (EGF) and DGF, before (T0) and 24 h after transplantation (T24). In pretransplant biopsies, T-bet(+) , GATA-3(+) and IL-17(+) cells were barely detectable. In DGF, T-bet(+) and IL-17(+) cells were significantly increased compared with pretransplant and ATD. More than 90% of T-bet(+) and less then 5% of IL-17(+) cells were CD4(+) . GATA-3(+) cells were increased to a lower extent. T-bet(+) /GATA-3(+) cell ratio was significantly higher in DGF. Peripheral CD4(+) IFN-γ/IL-4 ratio was significantly decreased in DGF, while CD4(+) /IL-17(+) cells did not differ between T0 and T24 in DGF. Our data suggest that DGF is characterized by a prevalent Th1 phenotype within the graft. This event might represent a link between DGF and acute rejection
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new targeted therapies based on specific biomarkers were recently investigated in the NEC of lung and in other types of breast carcinoma, which may provide guidance to their feasibility in breast NEC. Twenty breast NECs were profiled for biomarkers of therapy including antibody-drug conjugates (DLL3, TROP-2, and FOLR1), histone deacetylase (H3K36Me3) inhibitors, tropomyosin receptor kinases (NTRK1/2/3 gene fusions) targeted inhibitors, alkylating agents (MGMT), and immune checkpoint inhibitors (PD-L1, TMB, and MSI) using immunohistochemistry and DNA/RNA next-generation sequencing assays. Predictive expression of TROP-2, FOLR1, and H3K36Me3 were detected in different subsets of tumors and may pave the way for development of novel targeted therapies in some patients with breast NECs. There was no evidence of DLL3 expression, NTRK gene fusions, or MGMT hypermethylation. No biomarkers predictive of immune checkpoint inhibitor efficacy (programmed death-ligand 1 expression, tumor mutational burden, microsatellite instability) were identified. FGFR and CCND1 gene amplifications were detected in isolated cases. This study identified several potential targets for novel therapies in breast NEC, including farletuzumab and mirvetuximab soravtansine (FOLR1), sacituzumab govitecan (TROP-2), and HDAC inhibitors (H3K36Me3). In some cases, CCND1 gene amplification may indicate the usefulness of investigational therapies. The reported results should serve as an early indication of potential clinical relevance in selected patients with breast NEC
Variedades criollas (Vitis vinifera L.): conservación y puesta en valor del patrimonio genético vitivinícola
En el mundo existen más de 5000 variedades de vid diferentes. Entre ellas, sólo un grupo reducido son cultivadas comercialmente tanto para la elaboración de vino como para consumo en fresco. Esto ha dado origen al abandono de muchas variedades autóctonas por ser consideradas de menor calidad enológica. La Argentina es el quinto productor de
vinos y noveno exportador mundial, y ha basado su estrategia comercial en el cultivo de la variedad Malbec, la cual representa al menos un 50% de los vinos exportados. La imagen de Argentina como país productor asociado al Malbec es una ventaja competitiva, pero otros países ya han comenzado a producir vinos con esta variedad (ej. Francia, USA, Chile). Por lo tanto, con el presente proyecto se busca ampliar la oferta varietal para hacer frente a la fuerte competencia internacional. Una opción para elaborar productos con alta identidad regional es utilizar variedades criollas poco difundidas en el medio y con alto potencial enológico
Comparative morphological analysis of chronic and acute cigarette smoke effects on human keratinized oral mucosa: ex vivo and in vitro studies
Caracterización agronómica de Variedades Criollas de Vid
En el mundo existen más de 5000 variedades de vid diferentes. Entre ellas, sólo un grupo reducido son cultivadas comercialmente tanto para la elaboración de vino como para consumo en fresco. Esto ha dado origen al abandono de muchas variedades autóctonas por ser consideradas de menor calidad enológica. Argentina es el quinto productor de vinos y noveno exportador mundial, y ha basado su estrategia comercial en el cultivo de la variedad Malbec, la cual representa al menos un 50% de los vinos exportados. La imagen de Argentina como país productor asociado al Malbec es
una ventaja competitiva, pero otros países ya han comenzado a producir vinos con esta variedad (ej. Francia, USA, Chile). Por lo tanto, con el presente proyecto se busca ampliar la oferta varietal para hacer frente a la fuerte competencia internacional
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