178 research outputs found
The Halo Masses of Galaxies to z âŒ3: A Hybrid Observational and Theoretical Approach
© 2018. The American Astronomical Society. All rights reserved.. We use a hybrid observational/theoretical approach to study the relation between galaxy kinematics and the derived stellar and halo masses of galaxies up to z =3 as a function of stellar mass, redshift, and morphology. Our observational sample consists of a concatenation of 1125 galaxies with kinematic measurements at 0.4 < z < 3 from long-slit and integral field studies. We investigate several ways to measure halo masses from observations based on results from semi-analytical models, showing that galaxy halo masses can be retrieved with a scatter of âŒ0.4 dex by using only stellar masses. We discover a third parameter, relating to the time of the formation of the halo, that reduces the scatter in the relation between the stellar and halo masses such that systems forming earlier have a higher stellar mass-to-halo mass ratio, which we also find observationally. We find that this scatter correlates with morphology such that early-type or older stellar systems have higher M â/M halo ratios. We furthermore show, using this approach and through weak lensing and abundance matching, that the ratio of stellar to halo mass does not significantly evolve with redshift at 1 < z < 3. This is evidence for the regulated hierarchical assembly of galaxies such that the ratio of stellar to dark matter mass remains approximately constant since z =2. We use these results to show that the dark matter accretion rate evolves from dM halo/d t âŒ4000 yr-1 at z âŒ2.5 to a few 100 yr-1 by z âŒ0.5
The Clustering of Extremely Red Objects
We measure the clustering of Extremely Red Objects (EROs) in ~8 deg^2 of the
NOAO Deep Wide Field Survey Bo\"otes field in order to establish robust links
between ERO z~1.2 and local galaxy z<0.1 populations. Three different color
selection criteria from the literature are analyzed to assess the consequences
of using different criteria for selecting EROs. Specifically, our samples are
(R-K_s)>5.0 (28,724 galaxies), (I-K_s)>4.0 (22,451 galaxies) and (I-[3.6])>5.0
(64,370 galaxies). Magnitude-limited samples show the correlation length (r_0)
to increase for more luminous EROs, implying a correlation with stellar mass.
We can separate star-forming and passive ERO populations using the (K_s-[24])
and ([3.6]-[24]) colors to K_s=18.4 and [3.6]=17.5, respectively. Star-forming
and passive EROs in magnitude limited samples have different clustering
properties and host dark halo masses, and cannot be simply understood as a
single population. Based on the clustering, we find that bright passive EROs
are the likely progenitors of >4L^* elliptical galaxies. Bright EROs with
ongoing star formation were found to occupy denser environments than
star-forming galaxies in the local Universe, making these the likely
progenitors of >L^* local ellipticals. This suggests that the progenitors of
massive >4L^* local ellipticals had stopped forming stars by z>1.2, but that
the progenitors of less massive ellipticals (down to L^*) can still show
significant star formation at this epoch.Comment: 19 pages, 16 figures, 4 tables, Accepted to ApJ 27th November 201
The Clustering and Halo Masses of Star Forming Galaxies at z<1
We present clustering measurements and halo masses of star forming galaxies
at 0.2 < z < 1.0. After excluding AGN, we construct a sample of 22553 24 {\mu}m
sources selected from 8.42 deg^2 of the Spitzer MIPS AGN and Galaxy Evolution
Survey of Bo\"otes. Mid-infrared imaging allows us to observe galaxies with the
highest star formation rates (SFRs), less biased by dust obscuration afflicting
the optical bands. We find that the galaxies with the highest SFRs have optical
colors which are redder than typical blue cloud galaxies, with many residing
within the green valley. At z > 0.4 our sample is dominated by luminous
infrared galaxies (LIRGs, L_TIR > 10^11 Lsun) and is comprised entirely of
LIRGs and ultra-luminous infrared galaxies (ULIRGs, L_TIR > 10^12 Lsun) at z >
0.6. We observe weak clustering of r_0 = 3-6 Mpc/h for almost all of our star
forming samples. We find that the clustering and halo mass depend on L_TIR at
all redshifts, where galaxies with higher L_TIR (hence higher SFRs) have
stronger clustering. Galaxies with the highest SFRs at each redshift typically
reside within dark matter halos of M_halo ~ 10^12.9 Msun/h. This is consistent
with a transitional halo mass, above which star formation is largely truncated,
although we cannot exclude that ULIRGs reside within higher mass halos. By
modeling the clustering evolution of halos, we connect our star forming galaxy
samples to their local descendants. Most star forming galaxies at z < 1.0 are
the progenitors of L < 2.5L* blue galaxies in the local universe, but star
forming galaxies with the highest SFRs (L_TIR >10^11.7 Lsun) at 0.6<z<1.0 are
the progenitors of early-type galaxies in denser group environments.Comment: 18 pages, 16 figures, 2 tables. Accepted for publication in the
Astrophysical Journa
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Caveolin-1 enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma model
<p>Abstract</p> <p>Background</p> <p>Resveratrol (RES), an estrogen analog, is considered as a potential cancer chemo-preventive agent. However, it remains unclear how RES is transported into cells. In this study, we observed that Caveolin-1(CAV1) expression can increase the cytotoxic and pro-apoptotic activity of RES in a dose- and time-dependent manner both <it>in vitro </it>and <it>in vivo </it>in a Hepatocellular Carcinoma animal model.</p> <p>Methods</p> <p>High performance liquid chromatography (HPLC) demonstrated that RES intra-cellular concentration is increased about 2-fold in cells stably expressing CAV1 or CAVM1 (a scaffolding domain (81-101AA)-defective CAV1 mutant) compared to the untransduced human Hepatoblastoma cell line (HepG2) or after transduction with the green fluorescent protein (GFP) control vector. The increased intra-cellular transport of RES was abolished in cells stably expressing CAVM2 (a cholesterol shuttle domain (143-156AA)-defective CAV1 mutant) or CAVRNAi. In order to further characterize CAV1-dependent RES transport, we synthesized RES-dansyl chloride derivatives as fluorescent probes to visualize the transport process, which demonstrated a distribution consistent with that of CAV1 in HepG2 cells.</p> <p>Results</p> <p>In addition, RES endocytosis was not mediated by estrogen receptor (ER) α and ÎČ, as suggested by lack of competitive inhibition by estrogen or Tamoxifen. Pathway analysis showed that RES can up-regulate the expression of endogenous CAV1; this activates further the MAPK pathway and caspase-3 expression.</p> <p>Discussion</p> <p>This study provides novel insights about the role played by CAV1 in modulating cellular sensitivity to RES through enhancement of its internalization and trafficking.</p
The ecological forecast horizon, and examples of its uses and determinants
Forecasts of ecological dynamics in changing environments are increasingly important, and are available for a plethora of variables, such as species abundance and distribution, community structure and ecosystem processes. There is, however, a general absence of knowledge about how far into the future, or other dimensions (space, temperature, phylogenetic distance), useful ecological forecasts can be made, and about how features of ecological systems relate to these distances. The ecological forecast horizon is the dimensional distance for which useful forecasts can be made. Five case studies illustrate the influence of various sources of uncertainty (e.g. parameter uncertainty, environmental variation, demographic stochasticity and evolution), level of ecological organisation (e.g. population or community), and organismal properties (e.g. body size or number of trophic links) on temporal, spatial and phylogenetic forecast horizons. Insights from these case studies demonstrate that the ecological forecast horizon is a flexible and powerful tool for researching and communicating ecological predictability. It also has potential for motivating and guiding agenda setting for ecological forecasting research and development
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Improved imputation quality of low-frequency and rare variants in European samples using the âGenome of The Netherlands'
Although genome-wide association studies (GWAS) have identified many common variants associated with complex traits, low-frequency and rare variants have not been interrogated in a comprehensive manner. Imputation from dense reference panels, such as the 1000 Genomes Project (1000G), enables testing of ungenotyped variants for association. Here we present the results of imputation using a large, new population-specific panel: the Genome of The Netherlands (GoNL). We benchmarked the performance of the 1000G and GoNL reference sets by comparing imputation genotypes with âtrue' genotypes typed on ImmunoChip in three European populations (Dutch, British, and Italian). GoNL showed significant improvement in the imputation quality for rare variants (MAF 0.05â0.5%) compared with 1000G. In Dutch samples, the mean observed Pearson correlation, r2, increased from 0.61 to 0.71. We also saw improved imputation accuracy for other European populations (in the British samples, r2 improved from 0.58 to 0.65, and in the Italians from 0.43 to 0.47). A combined reference set comprising 1000G and GoNL improved the imputation of rare variants even further. The Italian samples benefitted the most from this combined reference (the mean r2 increased from 0.47 to 0.50). We conclude that the creation of a large population-specific reference is advantageous for imputing rare variants and that a combined reference panel across multiple populations yields the best imputation results
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene
Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with motherâs, and, to a lesser extent, with fatherâs TL having the strongest influence on the offspring. In this cohort, motherâs, but not fatherâs age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait
Observation of long ionizing tracks with the ICARUS T600 first half-module
F. Arneodo, B. Bade"ek, A. Badertscher, B. Baiboussinov, M. Baldo Ceolin, G. Battistoni, B. Bekman, P. Benetti, E. Bernardini, M. Bischofberger, A. Borio di Tigliole, R. Brunetti, A. Bueno, E. Calligarich, M. Campanelli, C. Carpanese, D. Cavalli, F. Cavanna, P. Cennini, S. Centro, A. Cesana, C. Chen, D. Chen, D.B. Chen, Y. Chen, D. Cline, Z. Dai, C. De Vecchi, A. Dabrowska, R. Dolfini*, M. Felcini, A. Ferrari, F. Ferri, Y. Ge, A. Gigli Berzolari, I. Gil-Botella, K. Graczyk, L. Grandi, K. He, J. Holeczek, X. Huang, C. Juszczak, D. Kie"czewska, J. Kisiel, T. Koz"owski, H. Kuna-Ciska", M. Laffranchi, J. Ćagoda, Z. Li, F. Lu, J. Ma, M. Markiewicz, A. Martinez de la Ossa, C. Matthey, F. Mauri, D. Mazza, G. Meng, M. Messina, C. Montanari, S. Muraro, S. Navas-Concha, M. Nicoletto, G. Nurzia, S. Otwinowski, Q. Ouyang, O. Palamara, D. Pascoli, L. Periale, G. Piano Mortari, A. Piazzoli, P. Picchi, F. Pietropaolo, W. P ! o"ch"opek, T. Rancati, A. Rappoldi, G.L. Raselli, J. Rico, E. Rondio, M. Rossella, A. Rubbia, C. Rubbia, P. Sala, D. Scannicchio, E. Segreto, F. Sergiampietri, J. Sobczyk, J. Stepaniak, M. Szeptycka, M. Szleper, M. Szarska, M. Terrani, S. Ventura, C. Vignoli, H. Wang, M. W ! ojcik, J. Woo, G. Xu, Z. Xu, A. Zalewska, J. Zalipska, C. Zhang, Q. Zhang, S. Zhen, W. Zipper a INFN Laboratori Nazionali del Gran Sasso, s.s. 17bis Km 18+910, Assergi (L'Aquila), Italy b Institute of Experimental Physics, Warsaw University, Warszawa, Poland c Institute for Particle Physics, ETH H . onggerberg, Z . urich, Switzerland Dipartimento di Fisica e INFN, Universit " a di Padova, via Marzolo 8, Padova, Italy Dipartimento di Fisica e INFN, Universit " a di Milano, via Celoria 16, Milano, Italy f Institute of Physics, University of Silesia, Katowice, Poland Dipartimento di Fisica e INFN, Universit " a di Pavia, via Bassi 6, Pavia, Italy Dpto de F!isica Te ! orica y del Cosmos & C.A.F.P.E., Universidad de Granada, Avda. Severo Ochoa s/n, Granada, Spain Dipartimento di Fisica e INFN, Universit " a dell'Aquila, via Vetoio, L'Aquila, Italy CERN, CH-1211 Geneva 23, Switzerland Politecnico di Milano (CESNEF), Universit " a di Milano, via Ponzio 34/3, Milano, Ital
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