Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation

Funding Information: This work was funded by Cancer Research UK Programme grant C5255/ A23755 and Wellcome Trust Investigator Award 209397/Z/17/Z. The funding body had no role in the design of the study; in the collection, analysis, and interpretation of data; or in the writing of the manuscript. Acknowledgements We thank Professor Simon Kroll and Dr. Anderson Ryan for their very helpful comments. We thank Dr. Jia-Yu Ke at Research Diets, Inc. for formulation of the mouse diets, Dr. Lisa Folkes for assistance with the faecal butyrate quantification, and Omega Bioservices (Georgia, USA) for the 16S rRNA gene sequencing on a MiSeq platform.Peer reviewedPublisher PD

The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo

Funding Information: This work was funded by Cancer Research UK (CRUK; C5255/A23755). J.L.R. was funded by CRUK (project grant C15140/A19817). C.K.T. was funded by a CRUK DPhil Research Training and Support Grant, the Balliol College Alfred Douglas Stone Scholarship, and the University of Oxford Clarendon Fund. S.K. was funded by a CRUK/MRC Oxford Institute of Radiation Oncology CRUK studentship.Peer reviewedPublisher PD

SN 2009ib: A Type II-P supernova with an unusually long plateau

We present optical and near-infrared photometry and spectroscopy of SN 2009ib, a Type II-P supernova in NGC 1559. This object has moderate brightness, similar to those of the intermediate-luminosity SNe 2008in and 2009N. Its plateau phase is unusually long, lasting for about 130 days after explosion. The spectra are similar to those of the subluminous SN 2002gd, with moderate expansion velocities. We es- timate the 56Ni mass produced as 0.046 ± 0.015 M⊙. We determine the distance to SN 2009ib using both the expanding photosphere method (EPM) and the standard candle method. We also apply EPM to SN 1986L, a type II-P SN that exploded in the same galaxy. Combining the results of different methods, we conclude the distance to NGC 1559 as D = 19.8 ± 3.0 Mpc. We examine archival, pre-explosion images of the field taken with the Hubble Space Telescope, and find a faint source at the position of the SN, which has a yellow colour ((V − I)0 = 0.85 mag). Assuming it is a single star, we estimate its initial mass as MZAMS = 20 M⊙. We also examine the possibility, that instead of the yellow source the progenitor of SN 2009ib is a red supergiant star too faint to be detected. In this case we estimate the upper limit for the initial zero-age main sequence mass of the progenitor to be ∼ 14 − 17 M⊙. In addition, we infer the physical properties of the progenitor at the explosion via hydrodynamical modelling of the observables, and estimate the total energy as ∼ 0.55 × 1051 erg, the pre-explosion radius as ∼ 400 R⊙, and the ejected envelope mass as ∼ 15 M⊙, which implies that the mass of the progenitor before explosion was ∼ 16.5 − 17 M

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

Funding Information: This work was funded by Cancer Research UK (CRUK) program grant C5255/A23755 to A.E.K. Medical Research Council UK (MRC) program grant MC_PC 12001/1 (MC_UU_00001/1) and Breast Cancer Now (Grant No. 2019DecPR1406) to K.R. S.K. was supported by the MRC Oxford Institute of Radiation Oncology (OIRO) CRUK studentship. We thank Dr. Sovan Sarkar (Department of Oncology, University of Oxford) for generously providing DR-GFP U2OS cells. We thank Diogo Dias (Ludwig Cancer Research Institute, University of Oxford) for his technical advice on HR and SSA assays and assistance with the analysis. We thank Dr. Lisa Folkes and Alix Hampson for the high-performance liquid chromatography (HPLC) analysis of CB-5083 concentration in tissue extracts from CD-1 nude mice bearing subcutaneous RT112 tumors. We also thank the Oxford Radcliffe Biobank for providing us with human tissue sections.Peer reviewedPublisher PD

SN 2011hs: a fast and faint Type IIb supernova from a supergiant progenitor

Observations spanning a large wavelength range, from X-ray to radio, of the Type IIb supernova (SN) 2011hs are presented, covering its evolution during the first year after explosion. The optical light curve presents a narrower shape and a fainter luminosity at peak than previously observed for Type IIb SNe. High expansion velocities are measured from the broad absorption H I and He I lines. From the comparison of the bolometric light curve and the time evolution of the photospheric velocities with hydrodynamical models, we found that SN 2011hs is consistent with the explosion of a 3–4 M⊙ He-core progenitor star, corresponding to a main-sequence mass of 12–15 M⊙, that ejected a mass of 56Ni of about 0.04 M⊙, with an energy of E = 8.5 × 1050 ERG. Such a low-mass progenitor scenario is in full agreement with the modelling of the nebular spectrum taken at ∼215 d from maximum. From the modelling of the adiabatic cooling phase, we infer a progenitor radius of ≈500–600 R⊙, clearly pointing to an extended progenitor star. The radio light curve of SN 2011hs yields a peak luminosity similar to that of SN 1993J, but with a higher mass-loss rate and a wind density possibly more similar to that of SN 2001ig. Although no significant deviations from a smooth decline have been found in the radio light curves, we cannot rule out the presence of a binary companion star

SN 2009N: linking normal and subluminous Type II-P SNe

We present ultraviolet, optical, near-infrared photometry and spectroscopy of SN 2009N in NGC 4487. This object is a Type II-P supernova with spectra resembling those of subluminous II-P supernovae, while its bolometric luminosity is similar to that of the intermediate-luminosity SN 2008in. We created SYNOW models of the plateau phase spectra for line identification and to measure the expansion velocity. In the near-infrared spectra we find signs indicating possible weak interaction between the supernova ejecta and the pre-existing circumstellar material. These signs are also present in the previously unpublished near-infrared spectra of SN 2008in. The distance to SN 2009N is determined via the expanding photosphere method and the standard candle method as D = 21.6 +/- 1.1 Mpc. The produced nickel-mass is estimated to be similar to 0.020 +/- 0.004 M-circle dot. We infer the physical properties of the progenitor at the explosion through hydrodynamical modelling of the observables. We find the values ofthe total energy as similar to 0.48 x 10(51) erg, the ejected mass as similar to 11.5 M-circle dot, and the initial radius as similar to 287 R-circle dot.</p

SN 2009N: linking normal and subluminous Type II-P Sne

We present ultraviolet, optical, near-infrared photometry and spectroscopy of SN 2009N in NGC 4487. This object is a type II-P supernova with spectra resembling those of subluminous II-P supernovae, while its bolometric luminosity is similar to that of the intermediate luminosity SN 2008in. We created SYNOW models of the plateau phase spectra for line identification and to measure the expansion velocity. In the near-infrared spectra we find signs indicating possible weak interaction between the supernova ejecta and the pre-existing circumstellar material. These signs are also present in the previously unpublished near-infrared spectra of SN 2008in. The distance to SN 2009N is determined via the expanding photosphere method and the standard candle method as $D= 21.6 \pm 1.1\,{\mathrm {Mpc}}$. The produced nickel-mass is estimated to be $\sim 0.020 \pm 0.004\,{\mathrm M_\odot}$. We infer the physical properties of the progenitor at the explosion through hydrodynamical modelling of the observables. We find the values of the total energy as $\sim 0.48 \times 10^{51}\, {\mathrm {erg}}$, the ejected mass as $\sim 11.5\,{\mathrm M_\odot}$, and the initial radius as $\sim 287\,{\mathrm R_\odot}$.Comment: 23 pages, 18 figures, accepted for publication by MNRA

SN 2009ib: a Type II-P supernova with an unusually long plateau

We present optical and near-infrared photometry and spectroscopy of SN 2009ib, a Type II-P supernova in NGC 1559. This object has moderate brightness, similar to those of the intermediate-luminosit ..