Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

It is widely known that epigenetic modifications are important in regulating transcription, but several have also been reported in alternative splicing. The regulation of pre-mRNA splicing is important to explain proteomic diversity and the misregulation of splicing has been implicated in many diseases. Here, we give a brief overview of the role of epigenetics in alternative splicing and disease. We then discuss the bioinformatics methods that can be used to model interactions between epigenetic marks and regulators of splicing. These models can be used to identify alternative splicing and epigenetic changes across different phenotypes

Exploring the variability among smallholder farms in the banana-based farming systems in Bukoba district, Northwest Tanzania

A study was conducted in the high and low rainfall zones in the banana-based farming system in Bukoba district, Tanzania, to explore the variability among household characteristics and farm productivity. Approaches used included a participatory rural appraisal, rapid system characterization, surveys and detailed farm monitoring in two villages, one from each zone in 2005 through 2006. Based on a wealth-ranking, four household resource groups with decreasing wealth were identified: Resource group 1 > Resource group 2 > Resource group 3 > Resource group 4, distinguished by domestic assets, livestock ownership and labour relations. Through principal component analysis using additional variables defined by research team, three Functional Resource Groups from among the four Resource groups at each rainfall zone were identified distinguished by: soil fertility management, food security and farm and off-farm income as important indicators of variability. Further detailed monitoring over 14 months (from March, 2006 through May, 2007) in at least three households from each functional resource group showed that N, P and K balances among land use types and farms were driven by levels of organic inputs used and were also related to wealth and dependence on off-farm activities. However, all households were net food buyers, implying food insecurity. In addition, off-farm activities and off-farm income were important livelihood survival strategie

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism

Peer reviewedPublisher PD

Structure and diversity of fish communities in man-made ponds of the Niger Delta (southern Nigeria)

1. A survey of eight local earthen hand-dug ponds located within the freshwater swamps of a Niger Delta area (southern Nigeria) was conducted over a period of 3 months. A total of 4,313 fishes representing 19 species from 12 families were recorded.2. The most abundant species was Xenomystus nigri (905 individuals), whereas the least common was Protopterus annectens (13). Cichlidae and Clariidae counted three species each, whereas Anabantidae, Hepsetidae, Mochokidae, Protopteridae, Phractolaemidae, Malapteruridae and Gymnarchidae were represented by a single species each.3. A lotic species, Synodontis sp., was recorded possibly as a result of the episodic flood of 2012.4. The Engenni swamps harbour a moderately diverse ichthyofauna. Regulations should be put in place to further enhance the fisheries potential of these local ponds

Rapid Variability of Gamma-Ray Blazars: A Model for MKN 421

The extremely rapid burst of TeV photons from Mkn 421 (15 May 1996) can be reconciled with the standard properties of a relativistic gamma-ray emitting jet (bulk Lorentz factor $\approx$ 10; size \10^{17} cm) if one assumes that the electrons are accelerated in conical shocks with both opening and viewing angles $\approx 1/\Gamma$. If the injection time and the cooling time are much less than the photon crossing time, an emission ring moves along the jet and leads to the appearance of a very rapid flare, in satisfactory agreement with the observations.Comment: 12 pages, 3 figures, uses aasms4.sty, to appear in ApJ Letter

Subacute pericardial abscess after aortic valve replacement: a case report

BACKGROUND: Purulent pericarditis is an infectious disease, frequently caused by gram-positive bacteria, that is rarely observed in healthy individuals, and is often associated with predisposing conditions. CASE PRESENTATION: Here, we present the case of an Escherichia coli post-surgical localized purulent pericarditis complicated by transient constrictive pericarditis and its diagnostic and therapeutic management. CONCLUSIONS: Our case report focuses on the importance of imaging-guided treatment of purulent pericardial diseases, in particular on the emerging role of 18\u2009F-labelled 2-fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in pericardial diseases and on the management of transient constrictive pericarditis, often seen after thoracic surgery