A novel palaeoaltimetry proxy based on spore and pollen wall chemistry

Understanding the uplift history and the evolution of high altitude plateaux is of major interest to a wide range of geoscientists and has implications for many disparate fields. Currently the majority of palaeoaltimetry proxies are based on detecting a physical change in climate in response to uplift, making the relationship between uplift and climate difficult to decipher. Furthermore, current palaeoaltimetry proxies have a low degree of precision with errors typically greater than 1 km. This makes the calculation of uplift histories and the identification of the mechanisms responsible for uplift difficult to determine. Here we report on advances in both instrumentation and our understanding of the biogeochemical structure of sporopollenin that are leading to the establishment of a new proxy to track changes in the flux of UV-B radiation over geological time. The UV-B proxy is based on quantifying changes in the concentration of UV-B absorbing compounds (UACs) found in the spores and pollen grains of land plants, with the relative abundances of UACs increasing on exposure to elevated UV-B radiation. Given the physical relationship between altitude and UV-B radiation we suggest that the analysis of sporopollenin chemistry, specifically changes in the concentration of UACs, may offer the basis for the first climate independent palaeoaltimetry proxy. Owing to the ubiquity of spores and pollen in the fossil record our proposed proxy has the potential to enable the reconstruction of the uplift history of high altitude plateaux at unprecedented levels of fidelity, both spatially and temporally

A highly virulent variant of HIV-1 circulating in the Netherlands.

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log <sub>10</sub> increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence

A highly virulent variant of HIV-1 circulating in the Netherlands

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence