Laboratórios de agrobiotecnologia: níveis de decisão em trajetórias de transferência de tecnologia

Historically the production of scientific knowledge in Argentina is characterized by a large gap between industry and scientific research. However, in recent years it can be seen premature cases of innovation which articulate relationships between researchers and companies. It is particulary interesting the study of agribiotechnology.The present work is carried out in the context of social studies of science and technology and it aims to analyze the trajectories of research and development laboratories cases which have projects in technology transfer to companies. The purpose is to characterize the strategies developed to guide their research in this direction.The general findings illustrate the existence of different levels of decision making that are key in achieving technology transfer. These decisions shape strategies which manage to coexist laboratory research and transfer.Históricamente la producción de conocimiento científico en Argentina se caracteriza por una gran separación entre el sector productivo y la investigación científica. Sin embargo, en los últimos años se puede observar incipientes casos de innovación que articulan relaciones entre los investigadores y empresas. Particularmente interesa estudiar el caso de la agrobiotecnología.Este trabajo se realiza en el marco de los estudios sociales de la ciencia y la tecnología y busca analizar las trayectorias de casos de laboratorios de investigación y desarrollo que tienen proyectos de transferencia tecnológica hacia empresas. El objetivo consiste en caracterizar las estrategias que desarrollan para orientar sus investigaciones en ese sentido.Las conclusiones generales ilustran la existencia de distintos niveles de decisión que resultan claves en la realización de la transferencia tecnológica. Esas decisiones conforman estrategias donde los laboratorios logran hacer coexistir actividades de investigación y transferencia.Historicamente a produção de conhecimento científico na Argentina é caracterizada por uma grande separação entre o setor produtivo e a investigação científica. No entanto, nos últimos anos podem se observar casos incipientes de inovação que articulam relações entre os investigadores e empresas. Particularmente interessa estudar o caso da agrobiotecnologia. Este trabalho é realizado no âmbito dos estudos sociais da ciência e a tecnologia e busca analisar as trajetórias de casos de laboratórios de pesquisa e desenvolvimento que têm projetos de transferência de tecnologia para empresas. O objetivo é caracterizar as estratégias desenvolvidas para orientar suas investigações nesse sentido. As conclusões gerais ilustram a existência de diferentes níveis de decisão que resultam fundamentais na realização da transferência de tecnologia. Essas decisões conformam estratégias onde os laboratórios conseguem fazer coexistir atividades de investigação e transferência

The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions

ObjectivesThis multicenter retrospective study of the initial U.S. experience evaluated the safety and efficacy of temporary cardiac pacing with the Tempo® Temporary Pacing Lead.BackgroundDespite increasing use of temporary cardiac pacing with the rapid growth of structural heart procedures, temporary pacing leads have not significantly improved. The Tempo lead is a new temporary pacing lead with a soft tip intended to minimize the risk of perforation and a novel active fixation mechanism designed to enhance lead stability.MethodsData from 269 consecutive structural heart procedures were collected. Outcomes included device safety (absence of clinically significant cardiac perforation, new pericardial effusion, or sustained ventricular arrhythmia) and efficacy (clinically acceptable pacing thresholds with successful pace capture throughout the index procedure). Postprocedure practices and sustained lead performance were also analyzed.ResultsThe Tempo lead was successfully positioned in the right ventricle and achieved pacing in 264 of 269 patients (98.1%). Two patients (0.8%) experienced loss of pace capture. Procedural mean pace capture threshold (PCT) was 0.7 ± 0.8 mA. There were no clinically significant perforations, pericardial effusions, or sustained device‐related arrhythmias. The Tempo lead was left in place postprocedure in 189 patients (71.6%) for mean duration of 43.3 ± 0.7 hr (range 2.5–221.3 hr) with final PCT of 0.84 ± 1.04 mA (n = 80). Of these patients, 84.1% mobilized out of bed with no lead dislodgment.ConclusionThe Tempo lead is safe and effective for temporary cardiac pacing for structural heart procedures, provides stable peri and postprocedural pacing and allows mobilization of patients who require temporary pacing leads.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154941/1/ccd28476.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154941/2/ccd28476_am.pd

Clinical impact of defibrillation testing at the time of implantable cardioverter-defibrillator insertion

Background: Ventricular fibrillation is routinely induced during implantable cardioverter- -defibrillator insertion to assess defibrillator performance, but this strategy is experiencing a progressive decline. We aimed to assess the efficacy of defibrillator therapies and long-term outcome in a cohort of patients that underwent defibrillator implantation with and without defibrillation testing. Methods: Retrospective observational series of consecutive patients undergoing initial defibrillator insertion or generator replacement. We registered spontaneous ventricular arrhythmias incidence and therapy efficacy, and mortality. Results: A total of 545 patients underwent defibrillator implantation (111 with and 434 without defibrillation testing). After 19 (range 9–31) months of follow-up, the death rate per observation year (4% vs. 4%; p = 0.91) and the rate of patients with defibrillator-treated ventricular arrhythmic events per observation year (with test: 10% vs. without test: 12%; p = 0.46) were similar. The generalized estimating equations-adjusted first shock probability of success in patients with test (95%; CI 88–100%) vs. without test (98%; CI 96–100%; p = 0.42) and the proportion of successful antitachycardia therapies (with test: 87% vs. without test: 80%; p = 0.35) were similar between groups. There was no difference in the annualized rate of failed first shock per patient and per shocked patient between groups (5% vs. 4%; p = 0.94). Conclusions: In this observational study, that included an unselected population of patients with a defibrillator, no difference was found in overall mortality, first shock efficacy and rate of failed shocks regardless of whether defibrillation testing was performed or not.Hadid, C.; Atienza, F.; Strasberg, B.; Arenal, Á.; Codner, P.; González-Torrecilla, E.; Datino, T.... (2015). Clinical impact of defibrillation testing at the time of implantable cardioverter-defibrillator insertion. Cardiology Journal. 22(3):253-259. doi:10.5603/Cj.a2014.0062S25325922

Impact of COVID-19 Pandemic on TAVR Activity: A Worldwide Registry

Background: The COVID-19 pandemic had a considerable impact on the provision of structural heart intervention worldwide. Our objectives were: 1) to assess the impact of the COVID-19 pandemic on transcatheter aortic valve replacement (TAVR) activity globally; and 2) to determine the differences in the impact according to geographic region and the demographic, development, and economic status of diverse international health care systems. Methods: We developed a multinational registry of global TAVR activity and invited individual TAVR sites to submit TAVR implant data before and during the COVID-19 pandemic. Specifically, the number of TAVR procedures performed monthly from January 2019 to December 2021 was collected. The adaptive measures to maintain TAVR activity by each site were recorded, as was a variety of indices relating to type of health care system and national economic indices. The primary subject of interest was the impact on TAVR activity during each of the pandemic waves (2020 and 2021) compared with the same period pre–COVID-19 (2019). Results: Data were received from 130 centers from 61 countries, with 14 subcontinents and 5 continents participating in the study. Overall, TAVR activity increased by 16.7% (2,337 procedures) between 2018 and 2019 (ie, before the pandemic), but between 2019 and 2020 (ie, first year of the pandemic), there was no significant growth (–0.1%; –10 procedures). In contrast, activity again increased by 18.9% (3,085 procedures) between 2020 and 2021 (ie, second year of the pandemic). During the first pandemic wave, there was a reduction of 18.9% (945 procedures) in TAVR activity among participating sites, while during the second and third waves, there was an increase of 6.7% (489 procedures) and 15.9% (1,042 procedures), respectively. Further analysis and results of this study are ongoing and will be available at the time of the congress. Conclusion: The COVID-19 pandemic initially led to a reduction in the number of patients undergoing TAVR worldwide, although health care systems subsequently adapted, and the number of TAVR recipients continued to grow in subsequent COVID-19 pandemic waves. Categories: STRUCTURAL: Valvular Disease: Aorti

Laboratorios de agrobiotecnología: niveles de decisión en trayectorias de transferencia tecnológica

Históricamente la producción de conocimiento científico en Argentina se caracteriza por una gran separación entre el sector productivo y la investigación científica. Sin embargo, en los últimos años se puede observar incipientes casos de innovación que articulan relaciones entre los investigadores y empresas. Particularmente interesa estudiar el caso de la agrobiotecnología.Este trabajo se realiza en el marco de los estudios sociales de la ciencia y la tecnología y busca analizar las trayectorias de casos de laboratorios de investigación y desarrollo que tienen proyectos de transferencia tecnológica hacia empresas. El objetivo consiste en caracterizar las estrategias que desarrollan para orientar sus investigaciones en ese sentido.Las conclusiones generales ilustran la existencia de distintos niveles de decisión que resultan claves en la realización de la transferencia tecnológica. Esas decisiones conforman estrategias donde los laboratorios logran hacer coexistir actividades de investigación y transferencia.Historically the production of scientific knowledge in Argentina is characterized by a large gap between industry and scientific research. However, in recent years it can be seen premature cases of innovation which articulate relationships between researchers and companies. It is particulary interesting the study of agribiotechnology.The present work is carried out in the context of social studies of science and technology and it aims to analyze the trajectories of research and development laboratories cases which have projects in technology transfer to companies. The purpose is to characterize the strategies developed to guide their research in this direction.The general findings illustrate the existence of different levels of decision making that are key in achieving technology transfer. These decisions shape strategies which manage to coexist laboratory research and transfer.Historicamente a produção de conhecimento científico na Argentina é caracterizada por uma grande separação entre o setor produtivo e a investigação científica. No entanto, nos últimos anos podem se observar casos incipientes de inovação que articulam relações entre os investigadores e empresas. Particularmente interessa estudar o caso da agrobiotecnologia. Este trabalho é realizado no âmbito dos estudos sociais da ciência e a tecnologia e busca analisar as trajetórias de casos de laboratórios de pesquisa e desenvolvimento que têm projetos de transferência de tecnologia para empresas. O objetivo é caracterizar as estratégias desenvolvidas para orientar suas investigações nesse sentido. As conclusões gerais ilustram a existência de diferentes níveis de decisão que resultam fundamentais na realização da transferência de tecnologia. Essas decisões conformam estratégias onde os laboratórios conseguem fazer coexistir atividades de investigação e transferência

Laboratorios de agrobiotecnología: niveles de decisión en trayectorias de transferencia tecnológica

Históricamente la producción de conocimiento científico en Argentina se caracteriza por una gran separación entre el sector productivo y la investigación científica. Sin embargo, en los últimos años se puede observar incipientes casos de innovación que articulan relaciones entre los investigadores y empresas. Particularmente interesa estudiar el caso de la agrobiotecnología. Este trabajo se realiza en el marco de los estudios sociales de la ciencia y la tecnología y busca analizar las trayectorias de casos de laboratorios de investigación y desarrollo que tienen proyectos de transferencia tecnológica hacia empresas. El objetivo consiste en caracterizar las estrategias que desarrollan para orientar sus investigaciones en ese sentido. Las conclusiones generales ilustran la existencia de distintos niveles de decisión que resultan claves en la realización de la transferencia tecnológica. Esas decisiones conforman estrategias donde los laboratorios logran hacer coexistir actividades de investigación y transferencia

Investigación científica e innovación tecnológica en Argentina: Impacto de los fondos de la Agencia Nacional de Promoción Científica y Tecnológica

El objetivo general de la evaluación ha sido verificar el grado de cumplimiento de las metas establecidas para el Programa de Modernización Tecnológica III, analizar los desvíos y sus posibles causas, medir el impacto del Programa y extraer enseñanzas que permitan realizar ajustes en el diseño y el proceso de implementación. El enfoque metodológico se oriento a la evaluación de impacto y se focalizó en el análisis de diversos indicadores de resultados.

La Transferencia Tecnológica en la universidad argentina: hacia una tipificación de estrategias de las oficinas de transferencia de las universidades nacionales de gestión pública

La innovación ha dejado de ser concebida como un proceso de decisión individual independiente del contexto, pasando a una conceptualización sistémica con actores insertos y entrelazados en distintas redes de instituciones. En ésta línea, las relaciones entre Universidades, empresas y gobierno resultan de particular interés para comprender las dinámicas de innovación local. El presente trabajo surge de un relevamiento nacional de 29 oficinas universitarias de transferencia tecnológica (realizado en 2015 con financiamiento del CIECTI-MINCYT), que se propuso analizar las dinámicas de transferencia y apropiación del conocimiento generado en las Universidades Nacionales y su relación con los procesos innovativos. A partir de un enfoque conceptual basado en la identificación y análisis de las capacidades esenciales de las oficinas, así como los canales para la transferencia y la extensión, en este trabajo se propone presentar algunos resultados preliminares respecto de la tipificación de visiones que permitirían hacer visibles algunas estrategias subyacentes.En particular, la priorización de determinados canales de transferencia por parte de los responsables de las OTT, han permitido agrupar y analizar clusters con visiones similares respecto de las acciones de transferencia, y cuyo análisis podría alimentar la discusión acerca de las estrategias de conexión y transferencia con el medio socio-productivo.Fil: Codner, Dario Gabriel. Universidad Nacional de Quilmes; ArgentinaFil: Becerra, Paulina. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martin, Dominique Ph.. Universidad Nacional de Quilmes; ArgentinaFil: Pellegrini, Pablo Ariel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lugones, Gustavo Eduardo. Universidad Nacional de Quilmes; Argentin