Multi-Wavelength View of Flare Events on November 20, 2003

We analyze two flare events which occurred in active region NOAA 501 on November 20, 2003. The H-alpha and magnetogram measurements show interaction between two filaments which produced a slowly rising flare event, corresponding to two stages of magnetic reconnection. The relative clockwise rotation between the two sunspot systems caused filament destabilization. The cusp-shaped magnetic field in the main phase of the second flare and its evolution in correlation with ribbon separation provide evidence for the cause of the CME eruption. The propagation and orientation of the CME with respect to the ecliptic plane is illustrated by IPS images.Comment: 4 pages, 4 figures; To appear in "Magnetic Coupling between the Interior and the Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200

Consistency in Vulnerability Assessments of Wheat to Climate Change—A District-Level Analysis in India

In India, a reduction in wheat crop yield would lead to a widespread impact on food security. In particular, the most vulnerable people are severely exposed to food insecurity. This study estimates the climate change vulnerability of wheat crops with respect to heterogeneities in time, space, and weighting methods. The study uses the Intergovernmental Panel on Climate Change (IPCC) framework of vulnerability while using composite indices of 27 indicators to explain exposure, sensitivity, and adaptive capacity. We used climate projections under current (1975–2005) conditions and two future (2021–2050) Representation Concentration Pathways (RCPs), 4.5 and 8.5, to estimate exposure to climatic risks. Consistency across three weighting methods (Analytical Hierarchy Process (AHP), Principal Component Analysis (PCA), and Equal Weights (EWs)) was evaluated. Results of the vulnerability profile suggest high vulnerability of the wheat crop in northern and central India. In particular, the districts Unnao, Sirsa, Hardoi, and Bathinda show high vulnerability and high consistency across current and future climate scenarios. In total, 84% of the districts show more than 75% consistency in the current climate, and 83% and 68% of the districts show more than 75% consistency for RCP 4.5 and RCP 8.5 climate scenario for the three weighting methods, respectively. By using different weighting methods, it was possible to quantify “method uncertainty” in vulnerability assessment and enhance robustness in identifying most vulnerable regions. Finally, we emphasize the importance of communicating uncertainties, both in data and methods in vulnerability research, to effectively guide adaptation planning. The results of this study would serve as the basis for designing climate impacts adjusted adaptation measures for policy interventions

Proper depiction of monsoon depression through IRS-P4 MSMR

In this paper, daily variations of satellite-derived geophysical parameters such as integrated water vapour (IWV), cloud liquid water content (CLW), sea surface temperature (SST) and sea surface wind speed (SSW) have been studied for a case of monsoon depression that formed over the Bay of Bengal during 19th-24th August 2000. For this purpose, IRS P4 MSMR satellite data have been utilized over the domain equator - 25°N and 40°-100°E. An integrated approach of satellite data obtained from IRS-P4, METEOSAT-5 and INSAT was made for getting a signal for the development of monsoon depression over the Indian region. Variations in deep convective activity obtained through visible, infrared and OLR data at 06 UTC was thoroughly analyzed for the complete life cycle of monsoon depression. Geophysical parameters obtained through IRS-P4 satellite data were compared with vorticity, convergence and divergence at 850 and 200 hPa levels generated through cloud motion vectors (CMVs) and water vapour wind vectors (WVWVs) obtained from METEOSAT-5 satellite. This comparison was made for finding proper consistency of geophysical parameters with dynamical aspects of major convective activity of the depression. From the results of this study it is revealed that there was strengthening of sea surface winds to the south of low-pressure area prior to the formation of depression. This indicated the possibility of increase in cyclonic vorticity in the lower troposphere. Hence, wind field at 850 hPa with satellite input of CMVs in objective analysis of wind field using optimum interpolation (OI) scheme was computed. Maximum cyclonic vorticity field at 850 hPa was obtained in the region of depression just one day before its formation. Similarly, with the same procedure maximum anticyclonic vorticity was observed at 200 hPa with WVWVs input. Consistent convergence and divergence at 850 and 200 hPa was noticed with respect to these vorticities. In association with these developments, we could get lowest values of OLR (120W/m 2) associated with major convective activity that was consistent with the maximum values of integrated water vapour (6-8 gm/cm 2) and cloud liquid water content (50-60 mg/cm 2) persisting particularly in the southwest sector of the monsoon depression

EMERGING QUALITY CONTROL PERSPECTIVES FOR AYURVEDIC DRUG

Ayush system of medicines based Herbal Pharmaceutical industry (ASU & H drug mfg) is having great potential and opportunities in India for development in future because of global acceptability of the medicinal plants & their value added products in Domestic & International Market as Ayurvedic, Unani and Siddha medicines, Herbal Nutraceuticals, Herbal Cosmoceutical, Herbal Health drinks, Dietary Health Supplements, Medicinal Plants / Crude Drugs, Herbal Extracts / Concentrates, Veterinary Medicines, Health Foods. India is rich with 771468 registered Ayush practitioners, 8667 licensed Ayurvedic drug manufacturing units. Quality Control/Assurance is the department, which controls all activities at various level of manufacturing as National & International standard. Ministry of Ayush continues to lay emphasis on up gradation of AYUSH educational standards, Quality control and standardisation of drugs, improving the availability of medicinal plant material, research and development and awareness generation about the efficacy of the system domestically and internationally. There are various issues & challenges related to drug quality for ASU&H Pharmaceutical Industries in India. It needs proper attention of policy makers and regulator & academia. Complete Implementation of GMP (schedule T) norm/guidelines and quality control/assurance procedure and activities is a big challenge for ensuring quality of drug

A multifaceted strategy using mobile technology to assist rural primary healthcare doctors and frontline health workers in cardiovascular disease risk management: protocol for the SMARTHealth India cluster randomised controlled trial

BACKGROUND: Blood Pressure related disease affected 118 million people in India in the year 2000; this figure will double by 2025. Around one in four adults in rural India have hypertension, and of those, only a minority are accessing appropriate care. Health systems in India face substantial challenges to meet these gaps in care, and innovative solutions are needed. METHODS: We hypothesise that a multifaceted intervention involving capacity strengthening of primary healthcare doctors and non-physician healthcare workers through use of a mobile device-based clinical decision support system will result in improved blood pressure control for individuals at high risk of a cardiovascular disease event when compared with usual healthcare. This intervention will be implemented as a stepped wedge, cluster randomised controlled trial in 18 primary health centres and 54 villages in rural Andhra Pradesh involving adults aged ≥40 years at high cardiovascular disease event risk (approximately 15,000 people). Cardiovascular disease event risk will be calculated based on World Health Organisation/International Society of Hypertension's region-specific risk charts. Cluster randomisation will occur at the level of the primary health centres. Outcome analyses will be conducted blinded to intervention allocation. EXPECTED OUTCOMES: The primary study outcome is the difference in the proportion of people meeting guideline-recommended blood pressure targets in the intervention period vs. the control period. Secondary outcomes include mean reduction in blood pressure levels; change in other cardiovascular disease risk factors, including body mass index, current smoking, reported healthy eating habits, and reported physical activity levels; self-reported use of blood pressure and other cardiovascular medicines; quality of life (using the EQ-5D); and cardiovascular disease events (using hospitalisation data). Trial outcomes will be accompanied by detailed process and economic evaluations. SIGNIFICANCE: The findings are likely to inform policy on a scalable strategy to overcome entrenched inequities in access to effective healthcare for under-served populations in low and middle income country settings. TRIAL REGISTRATION: Clinical Trial Registry India CTRI/2013/06/003753

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes

Does crop diversity contribute to dietary diversity? Evidence from integration of vegetables into maize-based farming systems

Background: Maize is the most important staple crop for food security and livelihood of smallholder farmers in many parts of sub-Saharan Africa, but it alone cannot ensure food security. Cropping patterns must be diversified to ensure an adequate supply and economic access to greater variety of foods for smallholder farm households. This study measured the effect of crop diversification on household dietary diversity in a selected study locale using a survey of 300 randomly stratified farm households in 10 villages located in the Babati, Kongwa and Kiteto districts of Tanzania. Results: Based on multiple regression analysis, the study found that simply increasing Simpson’s Index does not influence dietary diversity of farm households due to the presence of interaction effect between Simpson’s Index and crop income. It is much more critical and significant to increase the revenue generated from diversified crops along with other socioeconomic endowment and behavioral characteristics of farm households. This is particularly applicable to poorer smallholder farmers who receive crop income less than US$85 per sales transaction and per season. Particularly, marginal and smallholders might be exposed to the effects of crop diversification and crop income toward increasing in their household dietary diversity score. Conclusion: Under average crop income scenarios, households that diversify their crop production tend to increase their dietary diversity from their existing dietary diversity score at a decreasing rate. However, under below average crop income threshold scenarios, farmers tend to increase their dietary diversity score from their existing score at an increasing rate when they diversify into high-value crops that attract relatively high farm gate values and accrue higher net revenues from the market. Monthly food expenditure also tends to positively influence household dietary diversity, indicating that farm households that spend more on market-purchased food have consistent increases in their dietary diversity scores at the household level. This study concludes that improving economic access to variety of foods at the smallholder household level by diversifying diets through increased crop diversification should be encouraged within maize-based farming systems of the study locale, through integration of micronutrient-rich foods such as vegetables

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes