2,109 research outputs found
Self-adaptation of Mutation Rates in Non-elitist Populations
The runtime of evolutionary algorithms (EAs) depends critically on their
parameter settings, which are often problem-specific. Automated schemes for
parameter tuning have been developed to alleviate the high costs of manual
parameter tuning. Experimental results indicate that self-adaptation, where
parameter settings are encoded in the genomes of individuals, can be effective
in continuous optimisation. However, results in discrete optimisation have been
less conclusive. Furthermore, a rigorous runtime analysis that explains how
self-adaptation can lead to asymptotic speedups has been missing. This paper
provides the first such analysis for discrete, population-based EAs. We apply
level-based analysis to show how a self-adaptive EA is capable of fine-tuning
its mutation rate, leading to exponential speedups over EAs using fixed
mutation rates.Comment: To appear in the Proceedings of the 14th International Conference on
Parallel Problem Solving from Nature (PPSN
Finite temperature stability and dimensional crossover of exotic superfluidity in lattices
We investigate exotic paired states of spin-imbalanced Fermi gases in
anisotropic lattices, tuning the dimension between one and three. We calculate
the finite temperature phase diagram of the system using real-space dynamical
mean-field theory in combination with the quantum Monte Carlo method. We find
that regardless of the intermediate dimensions examined, the
Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) state survives to reach about one third
of the BCS critical temperature of the spin-density balanced case. We show how
the gapless nature of the state found is reflected in the local spectral
function. While the FFLO state is found at a wide range of polarizations at low
temperatures across the dimensional crossover, with increasing temperature we
find out strongly dimensionality-dependent melting characteristics of shell
structures related to harmonic confinement. Moreover, we show that intermediate
dimension can help to stabilize an extremely uniform finite temperature FFLO
state despite the presence of harmonic confinement.Comment: 5 pages, 3 figure
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.
Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1. We report here that Rsk phosphorylation of Emi2 promotes its interaction with the protein phosphatase PP2A. Emi2 residues adjacent to the Rsk phosphorylation site were important for PP2A binding. An Emi2 mutant that retained Rsk phosphorylation but lacked PP2A binding could not be modulated by Mos. PP2A bound to Emi2 acted on two distinct clusters of sites phosphorylated by Cdc2, one responsible for modulating its stability during CSF arrest and one that controls binding to the APC. These findings provide a molecular mechanism for Mos action in promoting CSF arrest and also define an unusual mechanism, whereby protein phosphorylation recruits a phosphatase for dephosphorylation of distinct sites phosphorylated by another kinase
Near surface nutrient and phytoplankton distribution in the Drake Passage during early December
Nutrient concentrations and phytoplankton species composition in near surface samples were studied along a S-N gradient in the Drake Passage, in early December 1984. Nitrate concentrations were much lower than usually previously reported from circum-Antarctic waters. Comparison of dissolved nutrient concentrations with growth requirements of Antarctic plankton algae suggests potential limitation of at least some species by nitrate or silicate. The taxonomic composition of the phytoplankton in our samples seemed to be partially controlled by competition for limiting nutrients
A Land System representation for global assessments and land-use modeling
Current global scale land-change models used for integrated assessments and climate modeling are based on classifications of land cover. However, land-use management intensity and livestock keeping are also important aspects of land use, and are an integrated part of land systems. This article aims to classify, map, and to characterize Land Systems (LS) at a global scale and analyze the spatial determinants of these systems. Besides proposing such a classification, the article tests if global assessments can be based on globally uniform allocation rules. Land cover, livestock, and agricultural intensity data are used to map LS using a hierarchical classification method. Logistic regressions are used to analyze variation in spatial determinants of LS. The analysis of the spatial determinants of LS indicates strong associations between LS and a range of socioeconomic and biophysical indicators of human-environment interactions. The set of identified spatial determinants of a LS differs among regions and scales, especially for (mosaic) cropland systems, grassland systems with livestock, and settlements. (Semi-)Natural LS have more similar spatial determinants across regions and scales. Using LS in global models is expected to result in a more accurate representation of land use capturing important aspects of land systems and land architecture: the variation in land cover and the link between land-use intensity and landscape composition. Because the set of most important spatial determinants of LS varies among regions and scales, land-change models that include the human drivers of land change are best parameterized at sub-global level, where similar biophysical, socioeconomic and cultural conditions prevail in the specific regions. © 2012 Blackwell Publishing Ltd
Niche and neutral processes leave distinct structural imprints on indirect interactions in mutualistic networks
This is the final version. Available on open access from Wiley via the DOI in this recordData availability:
All data used in this analysis are publicly available from https://doi.org/10.5061/dryad.dncjsxkw2 (Sonne et al., 2020a, 2020b)Indirect interactions are central to ecological and evolutionary dynamics in pollination
communities, yet we have little understanding about the processes determining patterns of
indirect interactions, such as those between pollinators through shared flowering plants.
Instead, research has concentrated on the processes responsible for direct interactions and
whole-network structures. This is partly due to a lack of appropriate tools for characterising
indirect interaction structures, because traditional network metrics discard much of this
information. The recent development of tools for counting motifs (subnetworks depicting
interactions between a small number of species) in bipartite networks enable detailed analysis
of indirect interaction patterns. Here we generate plant-hummingbird pollination networks
based on three major assembly processes – neutral effects (species interacting in proportion to
abundance), morphological matching and phenological overlap – and evaluate the motifs
associated with each one. We find that different processes produce networks with significantly
different patterns of indirect interactions. Neutral effects tend to produce densely-connected
motifs, with short indirect interaction chains, and motifs where many specialists interact
indirectly through a single generalist. Conversely, niche-based processes (morphology and
phenology) produced motifs with a core of interacting generalists, supported by peripheral
specialists. These results have important implications for understanding the processes
determining indirect interaction structures.Royal Commission 1851Natural Environment Research Council (NERC)Danish National Research Foundatio
Collective Excitations of Holographic Quantum Liquids in a Magnetic Field
We use holography to study N=4 supersymmetric SU(Nc) Yang-Mills theory in the
large-Nc and large-coupling limits coupled to a number Nf << Nc of
(n+1)-dimensional massless supersymmetric hypermultiplets in the Nc
representation of SU(Nc), with n=2,3. We introduce a temperature T, a baryon
number chemical potential mu, and a baryon number magnetic field B, and work in
a regime with mu >> T,\sqrt{B}. We study the collective excitations of these
holographic quantum liquids by computing the poles in the retarded Green's
function of the baryon number charge density operator and the associated peaks
in the spectral function. We focus on the evolution of the collective
excitations as we increase the frequency relative to T, i.e. the
hydrodynamic/collisionless crossover. We find that for all B, at low
frequencies the tallest peak in the spectral function is associated with
hydrodynamic charge diffusion. At high frequencies the tallest peak is
associated with a sound mode similar to the zero sound mode in the
collisionless regime of a Landau Fermi liquid. The sound mode has a gap
proportional to B, and as a result for intermediate frequencies and for B
sufficiently large compared to T the spectral function is strongly suppressed.
We find that the hydrodynamic/collisionless crossover occurs at a frequency
that is approximately B-independent.Comment: 45 pages, 8 png and 47 pdf images in 22 figure
Occupational and leisure time physical activity in contrasting relation to ambulatory blood pressure
Background: While moderate and vigorous leisure time physical activities are well documented to decrease the risk for cardiovascular disease, several studies have demonstrated an increased risk for cardiovascular disease in workers with high occupational activity. Research on the underlying causes to the contrasting effects of occupational and leisure time physical activity on cardiovascular health is lacking. The aim of this study was to examine the relation of objective and self-report measures of occupational and leisure time physical activity with 24-h ambulatory systolic blood pressure (BP).
Methods: Results for self-reported physical activity are based on observations in 182 workers (60% male, mean age 51 years), while valid objective physical activity data were available in 151 participants. The usual level of physical activity was assessed by 5 items from the Job Content Questionnaire (high physical effort, lifting heavy loads, rapid physical activity, awkward body positions and awkward positions of head or arms at work) and one item asking about the general level of physical activity during non-working time. On a regular working day, participants wore an ambulatory BP monitor and an accelerometer physical activity monitor during 24 h. Associations were examined by means of Analysis of Covariance.
Results: Workers with an overall high level of self-reported occupational physical activity as well as those who reported to often lift heavy loads at work had a higher mean systolic BP at work, at home and during sleep. However, no associations were observed between objectively measured occupational physical activity and BP. In contrast, those with objectively measured high proportion of moderate and vigorous leisure time physical activity had a significantly lower mean systolic BP during daytime, while no differences were observed according to self-reported level of leisure time physical activity.
Conclusions: These findings suggest that workers reporting static occupational physical activities, unlike general physically demanding tasks characterized by dynamic movements of large muscle groups, are related to a higher daily systolic BP, while high objective levels of moderate and vigorous leisure time physical activity are related to lower daytime systolic BP. Ambulatory systolic BP may be a physiological explanatory factor for the contrasting effects of occupational and leisure time physical activity
Identification of a Danish breast/ovarian cancer family double heterozygote for BRCA1 and BRCA2 mutations
Mutations in the two breast cancer susceptibility genes BRCA1 and BRCA2 are associated with increased risk of breast and ovarian cancer. Patients with mutations in both genes are rarely reported and often involve Ashkenazi founder mutations. Here we report the first identification of a Danish breast and ovarian cancer family heterozygote for mutations in the BRCA1 and BRCA2 genes. The BRCA1 nucleotide 5215G > A/c.5096G > A mutation results in the missense mutation Arg1699Gln, while the BRCA2 nucleotide 859 + 4A > G/c.631 + 4A > G is novel. Exon trapping experiments and reverse transcriptase (RT)–PCR analysis revealed that the BRCA2 mutation results in skipping of exon 7, thereby introducing a frameshift and a premature stop codon. We therefore classify the mutation as disease causing. Since the BRCA1 Arg1699Gln mutation is also suggested to be disease-causing, we consider this family double heterozygote for BRCA1 and BRCA2 mutations
Methodology of determining student’s cognitive styles and its application for teaching physics
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