Contribuição ao estudo da formação do Partido Republicano Rio-Grandense (1882-1891)

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O que as teorias do reconhecimento têm a dizer sobre as manifestações de rua em 2013 no Brasil

Este artigo tem como objetivo discutir as teorias do reconhecimento como instrumental para a análise das manifestações de rua ocorridas no Brasil em junho de 2013. Examina três autores: Nancy Fraser, Axel Honneth e Judith Butler, descrevendo os pontos centrais da teoria do reconhecimento de cada um deles, para assim apontar as possibilidades e limites de sua aplicação no estudo em pauta. A hipótese que norteia o artigo é a seguinte: nas manifestações de rua de 2013, a ausência de sujeitos coletivos organizados caracterizou uma condição de dispersão e fragmentação, resultando em uma demanda por reconhecimento antipolítica e individualizada. Tendo em vista esse cenário, chegou-se à conclusão de que as teses de Judith Butler sobre reconhecimento foram as que se mostraram mais apropriadas à análise dos eventos.&nbsp

Notas a propósito de Ernesto Laclau

Artículo origina

Role of Globotriaosylceramide in Physiology and Pathology

At first glance, the biological function of globoside (Gb) clusters appears to be that of glycosphingolipid (GSL) receptors for bacterial toxins that mediate host-pathogen interaction. Indeed, certain bacterial toxin families have been evolutionarily arranged so that they can enter eukaryotic cells through GSL receptors. A closer look reveals this molecular arrangement allocated on a variety of eukaryotic cell membranes, with its role revolving around physiological regulation and pathological processes. What makes Gb such a ubiquitous functional arrangement? Perhaps its peculiarity is underpinned by the molecular structure itself, the nature of Gb-bound ligands, or the intracellular trafficking unleashed by those ligands. Moreover, Gb biological conspicuousness may not lie on intrinsic properties or on its enzymatic synthesis/degradation pathways. The present review traverses these biological aspects, focusing mainly on globotriaosylceramide (Gb3), a GSL molecule present in cell membranes of distinct cell types, and proposes a wrap-up discussion with a phylogenetic view and the physiological and pathological functional alternatives.Fil: Celi Castillo, Ana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Goldstein Raij, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Rosato Siri, María Victoria. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vasconcelos Esteves Pinto, Alipio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentin

A tímida presença da mulher na política brasileira : eleições municipais em Porto Alegre (2008)

Este artigo tem o objetivo de analisar a disputa das três candidatas de esquerda à Prefeitura de Porto Alegre em 2008. A proposta é a de verificar como as candidatas Luciana Genro, Maria do Rosário e Manuela D’Ávila construíram suas imagens e que conteúdos foram utilizados para suas apresentações aos eleitores. Uma questão fundamental de análise foi a presença da condição de mulher no discurso das candidatas. A pesquisa foi realizada durante o período oficial do primeiro turno da campanha municipal, correspondendo aos meses de veiculação da propaganda eleitoral gratuita, entre 15 de agosto e 1º de outubro de 2008.The purpose of this article is to analyze the electoral dispute between three left wing woman candidates to the Porto Alegre City Hall in the elections held in 2008. Its proposal is to investigate how the candidates Luciana Genro, Maria do Rosário, and Manuela D’Ávila constructed their images and what kind of contents they used in order to present themselves to the electorate. An important issue addressed to in the analysis is the presence of the woman condition in the candidates’ discourse. The research was developed during the first round of the official campaign, focusing the free electoral propaganda broadcasted on television and radio, from August, 15 to October, 1st of 2008

The effect of age and clinical circumstances on the outcome of red blood cell transfusion in critically ill patients

Introduction: Whether red blood cell (RBC) transfusion is beneficial remains controversial. In both retrospective and prospective evaluations, transfusion has been associated with adverse, neutral, or protective effects. These varying results likely stem from a complex interplay between transfusion, patient characteristics, and clinical context. The objective was to test whether age, comorbidities, and clinical context modulate the effect of transfusion on survival. Methods: By using the multiparameter intelligent monitoring in intensive care II database (v. 2.6), a retrospective analysis of 9,809 critically ill patients, we evaluated the effect of RBC transfusion on 30-day and 1-year mortality. Propensity score modeling and logistic regression adjusted for known confounding and assessed the independent effect of transfusion on 30-day and 1-year mortality. Sensitivity analysis was performed by using 3,164 transfused and non-transfused pairs, matched according the previously validated propensity model for RBC transfusion. Results: RBC transfusion did not affect 30-day or 1-year mortality in the overall cohort. Patients younger than 55 years had increased odds of mortality (OR, 1.71; P < 0.01) with transfusion. Patients older than 75 years had lower odds of 30-day and 1-year mortality (OR, 0.70; P < 0.01) with transfusion. Transfusion was associated with worse outcome among patients undergoing cardiac surgery (OR, 2.1; P < 0.01). The propensity-matched population corroborated findings identified by regression adjustment. Conclusion: A complex relation exists between RBC transfusion and clinical outcome. Our results show that transfusion is associated with improved outcomes in some cohorts and worse outcome in others, depending on comorbidities and patient characteristics. As such, future investigations and clinical decisions evaluating the value of transfusion should account for variations in baseline characteristics and clinical context. Electronic supplementary material The online version of this article (doi:10.1186/s13054-014-0487-z) contains supplementary material, which is available to authorized users

Responsiveness of pituitary to galanin throughout the reproductive cycle of male European sea bass (Dicentrarchus labrax)

The neuropeptide galanin (Gal) is a putative factor regulating puberty onset and reproduction through its actions on the pituitary. The present study investigated the pituitary responsiveness to galanin and the patterns of galanin receptors (Galrs) expression throughout the reproductive cycle of two years old male European sea bass (Dicentrarchus labrax), an important aquaculture species. Quantitative analysis of pituitary and hypothalamus transcript expression of four galr subtypes revealed differential regulation according to the testicular developmental stage, with an overall decrease in expression from the immature stage to the mid-recrudescence stage. Incubation of pituitary cells with mammalian 1-29 Gal peptide induced significant changes in cAMP concentration, with sensitivities that varied according to the testicular development stages. Furthermore 1-29 Gal was able to stimulate both follicle stimulating hormone (Fsh) and luteinizing hormone (Lh) release from pituitary cell suspensions. The magnitude of the effects and effective concentrations varied according to reproductive stage, with generalized induction of Fsh and Lh release in animals sampled in January (full spermiation). The differential expression of galrs in pituitary and hypothalamus across the reproductive season, together with the differential effects of Gal on gonadotropins release in vitro strongly suggests the involvement of the galaninergic system in the regulation the hypothalamus-pituitary-gonad axis of male sea bass. This is to our knowledge the first clear evidence for the involvement of galanin in the regulation of reproduction in non-mammalian vertebrates. (C) 2017 Elsevier Inc. All rights reserved.European Union Seventh Framework Programme [262336]Spanish Ministry of Science and Innovation (MICINN)Spanish Ministry of the Economy and Competitiveness (MINECO) [AGL2009-11086]Spanish Ministry of the Economy and CompetitivenessRegional Government of Valencia [PROME-TEOH/2014/051]info:eu-repo/semantics/acceptedVersio