5,061 research outputs found
Energy and environmental assessment and reuse of fluidised bed recycled carbon fibres
Carbon fibre reinforced plastic (CFRP) recycling and the reutilisation of the recovered carbon fibre (rCF) 2 can compensate for the high impacts of virgin carbon fibre (vCF) production. In this paper, we evaluate the 3 energy and environmental impacts of CF recycling by a fluidised bed process and reuse to manufacture a 4 CFRP material. A ‘gate-to gate’ life cycle model of the CFRP recycling route using papermaking and 5 compression moulding methods is developed based on energy analysis of the fluidised bed recycling process 6 and processing of rCF. Key recycling plant operating parameters, including plant capacity, feed rate, and air 7 2 in-leakage are investigated. Life cycle impact assessments demonstrate the environmental benefits of recycled 8 CFRP against end of life treatments-landfilling, incineration. The use of rCF to displace vCF based on 9 material indices (equivalent stiffness and equivalent strength) therefore proves to be a competitive alternative 10 for composite manufacture in terms of environmental impact
Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration:A whole cell recording study in situ
Sympathetic preganglionic neurones (SPNs) convey sympathetic activity flowing from the CNS to the periphery to reach the target organs. Although previous in vivo and in vitro cell recording studies have explored their electrophysiological characteristics, it has not been possible to relate these characteristics to their roles in cardiorespiratory reflex integration. We used the working heart–brainstem preparation to make whole cell patch clamp recordings from T3–4 SPNs (n = 98). These SPNs were classified by their distinct responses to activation of the peripheral chemoreflex, diving response and arterial baroreflex, allowing the discrimination of muscle vasoconstrictor-like (MVC(like), 39%) from cutaneous vasoconstrictor-like (CVC(like), 28%) SPNs. The MVC(like) SPNs have higher baseline firing frequencies (2.52 ± 0.33 Hz vs. CVC(like) 1.34 ± 0.17 Hz, P = 0.007). The CVC(like) have longer after-hyperpolarisations (314 ± 36 ms vs. MVC(like) 191 ± 13 ms, P < 0.001) and lower input resistance (346 ± 49 MΩ vs. MVC(like) 496 ± 41 MΩ, P < 0.05). MVC(like) firing was respiratory-modulated with peak discharge in the late inspiratory/early expiratory phase and this activity was generated by both a tonic and respiratory-modulated barrage of synaptic events that were blocked by intrathecal kynurenate. In contrast, the activity of CVC(like) SPNs was underpinned by rhythmical membrane potential oscillations suggestive of gap junctional coupling. Thus, we have related the intrinsic electrophysiological properties of two classes of SPNs in situ to their roles in cardiorespiratory reflex integration and have shown that they deploy different cellular mechanisms that are likely to influence how they integrate and shape the distinctive sympathetic outputs
Interference in the shared-Stroop task:a comparison of self- and other-monitoring
Co-actors represent and integrate each other's actions, even when they need not monitor one another. However, monitoring is important for successful interactions, particularly those involving language, and monitoring others' utterances probably relies on similar mechanisms as monitoring one's own. We investigated the effect of monitoring on the integration of self- and other-generated utterances in the shared-Stroop task. In a solo version of the Stroop task (with a single participant responding to all stimuli; Experiment 1), participants named the ink colour of mismatching colour words (incongruent stimuli) more slowly than matching colour words (congruent). In the shared-Stroop task, one participant named the ink colour of words in one colour (e.g. red), while ignoring stimuli in the other colour (e.g. green); the other participant either named the other ink colour or did not respond. Crucially, participants either provided feedback about the correctness of their partner's response (Experiment 3) or did not (Experiment 2). Interference was greater when both participants responded than when they did not, but only when their partners provided feedback. We argue that feedback increased interference because monitoring one's partner enhanced representations of the partner's target utterance, which in turn interfered with self-monitoring of the participant's own utterance
Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm
Laminin-111 (α1β1γ1) is a member of the Laminin family of extra-cellular matrix proteins that comprises 16 members, components of basement membranes. Laminin-111, one of the first Laminin proteins synthesised during embryogenesis, is required for basement membrane deposition and has essential roles in tissue morphogenesis and patterning. Yet, the mechanisms controlling Laminin-111 expression are poorly understood. We generated a zebrafish transgenic reporter line that reproduces faithfully the expression pattern of lama1, the gene encoding Laminin α1, and we used this reporter line to investigate lama1 transcriptional regulation. Our findings established that lama1 expression is controlled by intronic enhancers, including an enhancer directing expression in the paraxial mesoderm, anterior spinal cord and hindbrain, located in intron 1. We show that Hedgehog signalling is necessary and sufficient for lama1 transcription in the paraxial mesoderm and identify putative Gli/Zic binding sites that may mediate this control. These findings uncover a conserved role for Hedgehog signalling in the control of basement membrane assembly via its transcriptional regulation of lama1, and provide a mechanism to coordinate muscle cell fate specification in the zebrafish embryo
Divergence in Dialogue
Copyright: 2014 Healey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This work was supported by the Economic and Social Research Council (ESRC; http://www.esrc.ac.uk/) through the DynDial project (Dynamics of Conversational Dialogue, RES-062-23-0962) and the Engineering and Physical Sciences Research Council (EPSRC; http://www.epsrc.ac.uk/) through the RISER
project (Robust Incremental Semantic Resources for Dialogue, EP/J010383/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
An Exploration of the Control of Micturition Using a Novel in Situ Arterially Perfused Rat Preparation
Our goal was to develop and refine a decerebrate arterially perfused rat (DAPR) preparation that allows the complete bladder filling and voiding cycle to be investigated without some of the restrictions inherent with in vivo experimentation [e.g., ease and speed of set up (30 min), control over the extracellular milieu and free of anesthetic agents]. Both spontaneous (naturalistic bladder filling from ureters) and evoked (in response to intravesical infusion) voids were routinely and reproducibly observed which had similar pressure characteristics. The DAPR allows the simultaneous measurement of bladder intra-luminal pressure, external urinary sphincter–electromyogram (EUS–EMG), pelvic afferent nerve activity, pudendal motor activity, and permits excellent visualization of the entire lower urinary tract, during typical rat filling and voiding responses. The voiding responses were modulated or eliminated by interventions at a number of levels including at the afferent terminal fields (intravesical capsaicin sensitization–desensitization), autonomic (ganglion blockade with hexamethonium), and somatic motor (vecuronium block of the EUS) outflow and required intact brainstem/hindbrain-spinal coordination (as demonstrated by sequential hindbrain transections). Both innocuous (e.g., perineal stimulation) and nociceptive (tail/paw pinch) somatic stimuli elicited an increase in EUS–EMG indicating intact sensory feedback loops. Spontaneous non-micturition contractions were observed between fluid infusions at a frequency and amplitude of 1.4 ± 0.9 per minute and 1.4 ± 0.3 mmHg, respectively and their amplitude increased when autonomic control was compromised. In conclusion, the DAPR is a tractable and useful model for the study of neural bladder control showing intact afferent signaling, spinal and hindbrain co-ordination and efferent control over the lower urinary tract end organs and can be extended to study bladder pathologies and trial novel treatments
Spitzer Observations of Low Luminosity Isolated and Low Surface Brightness Galaxies
We examine the infrared properties of five low surface brightness galaxies
(LSBGs) and compare them with related but higher surface brightness galaxies,
using Spitzer Space Telescope images and spectra. All the LSBGs are detected in
the 3.6 and 4.5um bands, representing the stellar population. All but one are
detected at 5.8 and 8.0um, revealing emission from hot dust and aromatic
molecules, though many are faint or point-like at these wavelengths. Detections
of LSBGs at the far-infrared wavelengths, 24, 70, and 160um, are varied in
morphology and brightness, with only two detections at 160um, resulting in
highly varied spectral energy distributions. Consistent with previous
expectations for these galaxies, we find that detectable dust components exist
for only some LSBGs, with the strength of dust emission dependent on the
existence of bright star forming regions. However, the far-infrared emission
may be relatively weak compared with normal star-forming galaxies.Comment: 20 pages, 8 figures, accepted to Ap
Th Ages for Metal-Poor Stars
With a sample of 22 metal-poor stars, we demonstrate that the heavy element
abundance pattern (Z > 55) is the same as the r-process contributions to the
solar nebula. This bolsters the results of previous studies that there is a
universal r-process production pattern. We use the abundance of thorium in five
metal-poor stars, along with an estimate of the initial Th abundance based on
the abundances of stable r-process elements, to measure their ages. We have
four field red giants with errors of 4.2 Gyr in their ages and one M92 giant
with an error of 5.6 Gyr, based on considering the sources of observational
error only. We obtain an average age of 11.4 Gyr, which depends critically on
the assumption of an initial production ratio of Th/Eu of 0.496. If the
Universe is 15 Gyr old, then the initial Th/Eu value should be 0.590, in
agreement with some theoretical models of the r-process.Comment: 26 pages, to be published in Ap
Modelling the vascular response to sympathetic postganglionic nerve activity
AbstractThis paper explores the influence of burst properties of the sympathetic nervous system on arterial contractility. Specifically, a mathematical model is constructed of the pathway from action potential generation in a sympathetic postganglionic neurone to contraction of an arterial smooth muscle cell. The differential equation model is a synthesis of models of the individual physiological processes, and is shown to be consistent with physiological data.The model is found to be unresponsive to tonic (regular) stimulation at typical frequencies recorded in sympathetic efferents. However, when stimulated at the same average frequency, but with repetitive respiratory-modulated burst patterns, it produces marked contractions. Moreover, the contractile force produced is found to be highly dependent on the number of spikes in each burst. In particular, when the model is driven by preganglionic spike trains recorded from wild-type and spontaneously hypertensive rats (which have increased spiking during each burst) the contractile force was found to be 10-fold greater in the hypertensive case. An explanation is provided in terms of the summative increased release of noradrenaline. Furthermore, the results suggest the marked effect that hypertensive spike trains had on smooth muscle cell tone can provide a significant contribution to the pathology of hypertension
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