67 research outputs found
Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
International audienceAutism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs
The effect of climate conditions on inter-annual flowering variability monitored by pollen traps below the canopy in Draved Forest, Denmark
Feeding habits, sexual dimorphism and size at maturity of the lizard Cnemidophorus ocellifer (Spix, 1825) (Teiidae) in a reforested restinga habitat in northeastern Brazil
The many faces of biological individuality
Biological individuality is a major topic of discussion in biology and philosophy of biology. Recently, several objections have been raised against traditional accounts of biological individuality, including the objections of monism (the tendency to focus on a single individuality criterion and/or a single biological field), theory-centrism (the tendency to discuss only theory-based individuation), ahistoricity (the tendency to neglect what biologists of the past and historians of biology have said about biological individuality), disciplinary isolationism (the tendency to isolate biological individuality from other scientific and philosophical domains that have investigated individuality), and the multiplication of conceptual uncertainties (the lack of a precise definition of âbiological individualâ and related terms). In this introduction, I will examine the current philosophical landscape about biological individuality, and show how the contributions gathered in this special issue address these five objections. Overall, the aim of this issue is to offer a more diverse, unifying, and scientifically informed conception of what a biological individual is
Vampires in the village Ćœrnovo on the island of KorÄula: following an archival document from the 18th century
SrediĆĄnja tema rada usmjerena je na raĆĄÄlambu spisa pohranjenog u DrĆŸavnom arhivu u Mlecima (fond: Capi del Consiglio deâ Dieci: Lettere di Rettori e di altre cariche) koji se odnosi na dogaÄaj iz 1748. godine u korÄulanskom selu Ćœrnovo, kada su mjeĆĄtani â vjerujuÄi da su se pojavili vampiri â oskvrnuli nekoliko mjesnih grobova. U radu se podrobno iznose osnovni podaci iz spisa te reÄeni dogaÄaj analizira u ĆĄirem druĆĄtvenom kontekstu i prate se lokalna vjerovanja.The main interest of this essay is the analysis of the document from the State Archive in Venice (file: Capi del Consiglio deâ Dieci: Lettere di Rettori e di altre cariche) which is connected with the episode from 1748 when the inhabitants of the village Ćœrnove on the island of KorÄula in Croatia opened tombs on the local cemetery in the fear of the vampires treating.
This essay try to show some social circumstances connected with this event as well as a local vernacular tradition concerning superstitions
Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: two cases
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CO J = 3-]2 OBSERVATIONS OF IRC +10216
New observations of the CO J = 3-2 emission in the circumstellar envelope of IRC +10216 are presented. Strips maps of this source have been obtained at 0.5 arcmin spacing with an optical telescope, which allows the beam pattern to be determined very accurately. The observations are compared with the predictions of the standard thermal model of Kwan and Linke (1982), and the model and the observations are found to agree very well. However, the model predicts that the effective J = 3-2 source is much smaller than the beam size. It is concluded that the observations cannot further constrain the input parameters of the Kwan and Linke model
PrÀzision des Tensiometerverfahrens zur Bestimmung der Wundfestigkeit in Relation zum verwendeten Nahtmaterial
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