Optimal finite measurements and Gauss quadratures

We exhibit measurements for optimal state estimation which have a finite number of outcomes. This is achieved by a connection between finite optimal measurements and Gauss quadratures. The example we consider to illustrate this connection is that of state estimation on $N$ qubits, all in a same pure state. Extensions to state estimation of mixed states are also discussed.Comment: 7 pages, 2 figures, paragraph added at the end of the article (extension of the problem to general states

Directorium divini cultus ad Cathedralis Ecclesiae Minoriccensis : eiusque Dioecesis usum

Fecha de imprenta tomada del título

Modélisation numérique de la femme enceinte (Application en accidentologie routière)

.AIX-MARSEILLE2-BU Sci.Luminy (130552106) / SudocSudocFranceF

The PROMIS model to highlight the importance of the foetus to the validation of a pregnant woman model

The percentage of trauma during pregnancy related to road accident is between 50% and 75%. This type of trauma can result in premature birth or even foetal loss. To analyse and understand the injury mechanisms in pregnant women involved in a car accident, several studies proposed computational or physical tools to simulate accidents. Specific dummy and numerical models have been proposed and validated using experimental data from post-mortem human surrogate (PMHS) scaled with the equal-stress, equal-velocity scaling method to a pregnant woman. This study proposes to evaluate the reliability of this assumption and its scope

Assessing man-induced environmental changes in the Sepetiba Bay (Southeastern Brazil) with geochemical and satellite data

International audienceThe Sepetiba Bay, Southeastern Brazil, has undergone intense environmental changes due to anthropogenic influence. This work aims to: (i) evaluate the changes in the drainage landscape use over the last decades, (ii) identify new and past punctual and diffuse anthropogenic sources and assess risks of man-induced disturbances of the coastal zones of Sepetiba. A multivariate statistics approach on the sediment's elemental geochemical dataset discriminated three groups: the electroplating waste-affected elements (As, Cd, Pb, Cu and Zn), terrigenous elements (Si, K, Ti, Al and Fe), and biogenic and carbonate-derived elements (Ca, Mg, Mn, P, Ni, and Cr). Sediment core profiles of trace elements evidence records of former environmental impacts from old metallurgical wastes. Analysis of two Landsat images from 30 years ago and 2015 reveals a decrease in the mangrove area of nearly 26%. The ongoing suppression of mangroves could enhance the release of trace elements into the Sepetiba Bay, increasing the risks to human and biota health

HIV-1 gp120 envelope glycoprotein determinants for cytokine burst in human monocytes.

The first step of HIV infection involves the interaction of the gp120 envelope glycoprotein to its receptor CD4, mainly expressed on CD4+ T cells. Besides its role on HIV-1 entry, the gp120 has been shown to be involved in the production of IL-1, IL-6, CCL20 and other innate response cytokines by bystander, uninfected CD4+ T cells and monocytes. However, the gp120 determinants involved in these functions are not completely understood. Whether signalling leading to cytokine production is due to CD4 or other receptors is still unclear. Enhanced chemokine receptor binding and subsequent clustering receptors may lead to cytokine production. By using a comprehensive panel of gp120 mutants, here we show that CD4 binding is mandatory for cytokine outburst in monocytes. Our data suggest that targeting monocytes in HIV-infected patients might decrease systemic inflammation and the potential tissue injury associated with the production of inflammatory cytokines. Understanding how gp120 mediates a cytokine burst in monocytes might help develop new approaches to improve the chronic inflammation that persists in these patients despite effective suppression of viremia by antiretroviral therapy

D368R and R419D mutations are deleterious for the cytokine burst but dV1V2V3V5 mutation can rescue D368R.

<p>Cytokines detection after cell stimulation with the gp120 constructs collection. A) mRNA expression of cytokines done by RT-qPCR, level of expression after stimulation with gp120 mutants is relative to the mock control set at 1 for each graph. Left panel: PBMC and right panel: monocytes. B) Flow cytometry analysis of PBMC CD14+ population, expression of IL-10 and IL1-ß are detected by intra-cellular staining after gp120 mutants’ stimulation. C) PBMC supernatant analysis by ELISA detection of IL-10, TNF-α, IL-1ß and CCL2 after stimulation with gp120 mutants. Statistic analysis were performed with variance test ANOVA and then with a t-tests to compare positive conditions to the mock control (* p<0.05 and ** p<0.01).</p

Characterization of ligand binding to selected HIV-1_YU2 gp120 proteins by immunoprecipitation.

<p>Characterization of ligand binding to selected HIV-1_YU2 gp120 proteins by immunoprecipitation.</p