Short-term efficacy of ultramicronized palmitoylethanolamide in peripheral neuropathic pain.

Introduction. This study evaluates the efficacy of palmitoylethanolamide ultramicronized (PEA-um) as an add-on treatment in patients with diabetic or traumatic neuropathic pain (NP). Methods. 30 patients with chronic NP were assessed with Visual Analogue Scale (VAS), NP Symptom Inventory (NPSI), and Health Questionnaire Five Dimensions (EQ-5D), both at baseline and after 10 and 40 days of treatment with 1200 mg/die of PEA-um. All other therapies were maintained stable during the follow-up period. Results. VAS mean score significantly improved within the first 10 days, ranging from 8.20 ± 1.53 to 6.40 ± 1.83 (P<0.002), with a further decrease to 5.80 ± 2.04 (P<0.001) after 40 days of PEA-um administration. Moreover, NPSI total score improved from 5.2 ± 1.5 to 3.8 ± 2.1 (P: 0.025) and EQ-5D ranged from −0.30 ± 0.65 to 0.5 ± 0.34 (P<0.001) between T0 and T2. Conclusions. This study reports the prospective short-term efficacy data of oral PEA-um in patients with diabetic or traumatic NP. A significant improvement was observed both in VAS and NPSI scores and in quality of life scales after 40 days of treatment, although some limitations should be considered, including the short followup and the open-label study design

Experimental analysis and model validation of an opaque ventilated facade

Natural ventilation is a convenient way of reducing energy consumption in buildings. In this study an experimental module of an opaque ventilated façade (OVF) was built and tested for assessing its potential of supplying free ventilation and air preheating for the building. A numerical model was created and validated against the experimental data. The experimental results showed that the flow rates induced in the façade cavity were due to mixed driving forces: wind and buoyancy. Depending on the weather conditions one of them was the main driving force, or both were of the same order. When the wind force was the main driving force, higher flow rates were found. In these cases buoyancy acted as supporting driving force. When the wind speed was low and buoyancy prevailed lower flow rates were found. Air and surface temperatures were predicted by the numerical model with a better accuracy than flow and energy rates. The model predicts correctly the influence of the wind and buoyancy driving forces. The experimental OVF module showed potential for free ventilation and air preheating, although it depends on weather and geometrical variables. The use of the numerical model using the right parameters was found viable for analyzing the performance of an OVF

How do cardiologists select patients for dual antiplatelet therapy continuation beyond 1 year after a myocardial infarction? Insights from the EYESHOT Post-MI Study

Background: Current guidelines suggest to consider dual antiplatelet therapy (DAPT) continuation for longer than 12 months in selected patients with myocardial infarction (MI). Hypothesis: We sought to assess the criteria used by cardiologists in daily practice to select patients with a history of MI eligible for DAPT continuation beyond 1 year. Methods: We analyzed data from the EYESHOT Post-MI, a prospective, observational, nationwide study aimed to evaluate the management of patients presenting to cardiologists 1 to 3 years from the last MI event. Results: Out of the 1633 post-MI patients enrolled in the study between March and December 2017, 557 (34.1%) were on DAPT at the time of enrolment, and 450 (27.6%) were prescribed DAPT after cardiologist assessment. At multivariate analyses, a percutaneous coronary intervention (PCI) with multiple stents and the presence of peripheral artery disease (PAD) resulted as independent predictors of DAPT continuation, while atrial fibrillation was the only independent predictor of DAPT interruption for patients both at the second and the third year from MI at enrolment and the time of discharge/end of the visit. Conclusions: Risk scores recommended by current guidelines for guiding decisions on DAPT duration are underused and misused in clinical practice. A PCI with multiple stents and a history of PAD resulted as the clinical variables more frequently associated with DAPT continuation beyond 1 year from the index MI

Politizando o conceito de redes organizacionais: uma reflexão teórica da governança como jogo de poder

Este trabalho tem como objetivo apresentar uma reflexão teórica sobre a dimensão política das redes organizacionais. Para tanto, procurou fazer uma análise desse formato organizacional, privilegiando a dimensão política das relações interorganizacionais a partir de alguns conceitos formulados pelo sociólogo Pierre Bourdieu. As evidências teóricas revelaram que esse recorte analítico poderá oferecer leituras alternativas às reflexões que despolitizam o conceito de redes organizacionais, colocando no epicentro das argumentações a lógica da cooperação e da confiança como forças motrizes e suficientes para explicar o funcionamento das relações entre as organizações. Ao considerar as redes organizacionais como um campo social, este ensaio amplia a noção de governança, levando em consideração não só os aspectos estruturais e objetivos, mas também a dimensão subjetiva que permeia as relações entre os agentes