Figure-Figure Interaction Between Bodies Having Arbitrary Shapes and Mass Distributions: A Power Series Expansion Approach

We derive an expression for the mutual gravitational force and torque of two bodies having arbitrary shapes and mass distributions, as an expansion in power series of their products of inertia and of the relative coordinates of their centres of mass. The absolute convergence of all the power series developed is rigorously demonstrated. The absence of transcendental functions makes this formalism suitable for fast numerical applications. The products of inertia used here are directly related to the spherical harmonics coefficients, and we provide a detailed analysis of this relationship.Comment: 13 pages, accepted by Celestial Mechanics and Dynamical Astronom

LTTRPred: A tool for prediction of LysR-type transcriptional regulator of pyoluteorin pathway in plant growth promoting Pseudomonas spp.

Plant growth promoting Pseudomonas spp. produce an antifungal compound called pyoluteorin (Plt) that suppress diseases caused by phytopathogenic fungi. The pathway specific regulator PltR, a typical LysR-type transcriptional regulator (LTTR), is responsible for the transcriptional activation of the Plt biosynthetic operon. The LTTR family represents one of the largest classes of bacterial transcriptional regulatory proteins. A large number of LTTRs possess function as global transcriptional activators or repressors of unlinked genes or operons involved in metabolism, quinoline signal, virulence etc. The proposed method, LTTRPred, is an useful tool developed for identifying and predicting the LTTR, which is responsible for the activation of Plt transcription regulators, from whole genomes of various Pseudomonas spp. LTTRPred was developed using support vector machine (SVM) and Waikato Environment for Knowledge Analysis (WEKA) based on the composition of amino acid and amino acid pairs. Modules in SVM were developed using traditional amino acid, dipeptide (n+1) and hybrid amino acid composition modules and an overall accuracy of 100, 100 and 98 per cent respectively, was achieved. Modules in WEKA were also developed using the same modules and an overall accuracy of 100 per cent achieved for all. The performance of the tool was tested using various datasets of LTTR genes from different Pseudomonas spp. The best performing SVM and WEKA modules from the present investigation was implemented as a dynamic web server ‘LTTRPred’, which is freely available and can be accessed online (http://210.212.229.56/lttrpred/). This tool can be used for the functional annotation of the Pseudomonas spp. possessing LTTR genes

Neutron Diffraction Study of Field Cooling Effects on Relaxor Ferroelectrics Pb[(Zn_{1/3} Nb_{2/3})_{0.92} Ti_{0.08}] O_{3}

High-temperature (T) and high-electric-field (E) effects on Pb[(Zn_{1/3} Nb_{2/3})_{0.92} Ti_{0.08}]O_3 (PZN-8%PT) were studied comprehensively by neutron diffraction in the ranges 300 <= T <= 550 K and 0 <= E <= 15 kV/cm. We have focused on how phase transitions depend on preceding thermal and electrical sequences. In the field cooling process (FC, E parallel [001] >= 0.5 kV/cm), a successive cubic (C) --> tetragonal (T) --> monoclinic (M_C) transition was observed. In the zero field cooling process (ZFC), however, we have found that the system does not transform to the rhombohedral (R) phase as widely believed, but to a new, unidentified phase, which we call X. X gives a Bragg peak profile similar to that expected for R, but the c-axis is always slightly shorter than the a-axis. As for field effects on the X phase, we found an irreversible X --> M_C transition via another monoclinic phase (M_A) as expected from a previous report [Noheda et al. Phys. Rev. Lett. 86, 3891 (2001)]. At a higher electric field, we confirmed a c-axis jump associated with the field-induced M_C --> T transition, which was observed by strain and x-ray diffraction measurements.Comment: 8 pages, 9 figures, revise

A Hydrometeorological Assessment of the Historic 2019 Flood of Nebraska, Iowa, and South Dakota

During early 2019, a series of events set the stage for devastating floods in eastern Nebraska, western Iowa, and southeastern South Dakota. When the floodwaters hit, dams and levees failed, cutting off towns, while destroying roads, bridges, and rail lines, further exacerbating the crisis. Lives were lost and thousands of cattle were stranded. Estimates indicate that the cost of the flooding has topped $3 billion as of August 2019, with this number expected to rise. After a warm and wet start to winter, eastern Nebraska, western Iowa, and southeastern South Dakota endured anomalously low temperatures and record-breaking snowfall. By March 2019, rivers were frozen, frost depths were 60-90 cm, and the water equivalent of the snowpack was 30-100 mm. With these conditions in place, a record breaking surface cyclone rapidly developed in Colorado and propagated eastward, producing heavy rain towards the east and blizzard conditions toward the west. In areas of eastern Nebraska, western Iowa, and southeastern South Dakota, rapid melting of the snowpack due to this rain-on-snow event quickly led to excessive runoff that overwhelmed rivers and streams. These conditions brought the region to a standstill. In this paper, we will provide an analysis of the antecedent conditions in eastern Nebraska, western Iowa and southeastern South Dakota, the development of the surface cyclone that triggered the historic flooding, along with a look into the forecast and communication of flood impacts prior to the flood. The study used multiple datasets, including in-situ observations and reanalysis data. Understanding the events that led to the flooding could aid in future forecasting efforts

Phenolic compounds isolated from Pilea microphylla prevent radiation-induced cellular DNA damage

AbstractSix phenolic compounds namely, quercetin-3-O-rutinoside (1), 3-O-caffeoylquinic acid (2), luteolin-7-O-glucoside (3), apigenin-7-O-rutinoside (4), apigenin-7-O-β-d-glucopyranoside (5) and quercetin (6) were isolated from the whole plant of Pilea microphylla using conventional open-silica gel column chromatography and preparative HPLC. Further, these compounds were characterized by 1D, 2D NMR techniques and high-resolution LC–MS. Compounds 1–3 and 6 exhibited significant antioxidant potential in scavenging free radicals such as DPPH, ABTS and SOD with IC50 of 3.3–20.4μmol/L. The same compounds also prevented lipid peroxidation with IC50 of 10.4–32.2μmol/L. The compounds also significantly prevented the Fenton reagent-induced calf thymus DNA damage. Pre-treatment with compounds 1–3 and 6 in V79 cells attenuated radiation-induced formation of reactive oxygen species, lipid peroxidation, cytotoxicity and DNA damage, correlating the antioxidant activity of polyphenols with their radioprotective effects. Compounds 1, 3 and 6 significantly inhibited lipid peroxidation, presumably due to 3′,4′-catechol ortho-dihydroxy moiety in the B-ring, which has a strong affinity for phospholipid membranes. Oxidation of flavonoids, with catechol structure on B-ring, yields a fairly stable ortho-semiquinone radical by facilitating electron delocalization, which is involved in antioxidant mechanism. Hence, the flavonoid structure, number and location of hydroxyl groups together determine the antioxidant and radioprotection mechanism

Measurement of the 58Ni(α, γ) 62Zn reaction and its astrophysical impact

Funding Details: PHY 08-22648, NSF, National Science Foundation; PHY 0969058, NSF, National Science Foundation; PHY 1102511, NSF, National Science FoundationCross section measurements of the 58Ni(α,γ)62Zn reaction were performed in the energy range Eα=5.5to9.5 MeV at the Nuclear Science Laboratory of the University of Notre Dame, using the NSCL Summing NaI(Tl) detector and the γ-summing technique. The measurements are compared to predictions in the statistical Hauser-Feshbach model of nuclear reactions using the SMARAGD code. It is found that the energy dependence of the cross section is reproduced well but the absolute value is overestimated by the prediction. This can be remedied by rescaling the α width by a factor of 0.45. Stellar reactivities were calculated with the rescaled α width and their impact on nucleosynthesis in type Ia supernovae has been studied. It is found that the resulting abundances change by up to 5% when using the new reactivities. © 2014 American Physical Society.Peer reviewe

Spectral curves and the mass of hyperbolic monopoles

The moduli spaces of hyperbolic monopoles are naturally fibred by the monopole mass, and this leads to a nontrivial mass dependence of the holomorphic data (spectral curves, rational maps, holomorphic spheres) associated to hyperbolic multi-monopoles. In this paper, we obtain an explicit description of this dependence for general hyperbolic monopoles of magnetic charge two. In addition, we show how to compute the monopole mass of higher charge spectral curves with tetrahedral and octahedral symmetries. Spectral curves of euclidean monopoles are recovered from our results via an infinite-mass limit.Comment: 43 pages, LaTeX, 3 figure

Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): Exome sequencing of trios, monozygotic twins and tumours

BACKGROUND: Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is thought to be a genetic disease caused by de novo mutations, though causative mutations have yet to be identified. We searched for de novo coding mutations among a carefully-diagnosed and clinically homogeneous cohort of 35 ROHHAD patients. METHODS: We sequenced the exomes of seven ROHHAD trios, plus tumours from four of these patients and the unaffected monozygotic (MZ) twin of one (discovery cohort), to identify constitutional and somatic de novo sequence variants. We further analyzed this exome data to search for candidate genes under autosomal dominant and recessive models, and to identify structural variations. Candidate genes were tested by exome or Sanger sequencing in a replication cohort of 28 ROHHAD singletons. RESULTS: The analysis of the trio-based exomes found 13 de novo variants. However, no two patients had de novo variants in the same gene, and additional patient exomes and mutation analysis in the replication cohort did not provide strong genetic evidence to implicate any of these sequence variants in ROHHAD. Somatic comparisons revealed no coding differences between any blood and tumour samples, or between the two discordant MZ twins. Neither autosomal dominant nor recessive analysis yielded candidate genes for ROHHAD, and we did not identify any potentially causative structural variations. CONCLUSIONS: Clinical exome sequencing is highly unlikely to be a useful diagnostic test in patients with true ROHHAD. As ROHHAD has a high risk for fatality if not properly managed, it remains imperative to expand the search for non-exomic genetic risk factors, as well as to investigate other possible mechanisms of disease. In so doing, we will be able to confirm objectively the ROHHAD diagnosis and to contribute to our understanding of obesity, respiratory control, hypothalamic function, and autonomic regulation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13023-015-0314-x) contains supplementary material, which is available to authorized users

From ten to four and back again: how to generalize the geometry

We discuss the four-dimensional N=1 effective approach in the study of warped type II flux compactifications with SU(3)x SU(3)-structure to AdS_4 or flat Minkowski space-time. The non-trivial warping makes it natural to use a supergravity formulation invariant under local complexified Weyl transformations. We obtain the classical superpotential from a standard argument involving domain walls and generalized calibrations and show how the resulting F-flatness and D-flatness equations exactly reproduce the full ten-dimensional supersymmetry equations. Furthermore, we consider the effect of non-perturbative corrections to this superpotential arising from gaugino condensation or Euclidean D-brane instantons. For the latter we derive the supersymmetry conditions in N=1 flux vacua in full generality. We find that the non-perturbative corrections induce a quantum deformation of the internal generalized geometry. Smeared instantons allow to understand KKLT-like AdS vacua from a ten-dimensional point of view. On the other hand, non-smeared instantons in IIB warped Calabi-Yau compactifications 'destabilize' the Calabi-Yau complex structure into a genuine generalized complex one. This deformation gives a geometrical explanation of the non-trivial superpotential for mobile D3-branes induced by the non-perturbative corrections.Comment: LaTeX, 47 pages, v2, references, hyperref added, v3, correcting small inaccuracies in eqs. (2.6a) and (5.16

Hydrogen production from high temperature steam catalytic gasification of bio-char

Hydrogen production from the catalytic steam gasification of bio-char derived from the pyrolysis of sugar cane bagasse has been investigated in relation to gasification temperature up to 1050 °C, steam flow rate from 6 to 25 ml h−1 and type of Nickel catalyst. The catalysts used were Ni-dolomite, Ni–MgO and Ni–Al2O3, all with 10% nickel loading. The hydrogen yield in the absence of a catalyst at a gasification temperature of 950 °C was 100.97 mmol g−1 of bagasse char. However, the presence of the Ni–MgO and Ni–Al2O3 catalysts produced significantly improved hydrogen yields of 178.75 and 187.25 mmol g−1 of bagasse char respectively at 950 °C. The hydrogen yield from the char with the Ni-dolomite only showed a modest increase in hydrogen yield. The influence of gasification temperature showed that the optimum temperature to obtain the highest hydrogen yield was 950 °C. Increase in gasification temperature from 750 to 950 °C significantly increased hydrogen yield from 45.30 to 187.25 mmol g−1 of bagasse char at 950 °C, but was followed by a decrease in yield at 1050 °C. The influence of steam flow rate showed that with the increase in steam flow rate from 6 to 15 ml h−1 hydrogen yield was increased from 187.25 to 208.41 mmol g−1 of bagasse char. Further increase in steam flow rate resulted in a decrease in hydrogen yield