Estudio crítico de las gramíneas austral-americanas del género Agropyron

El género Agropyron comprende unas 65 especies distribuídas en las zonas templadas de ambos hemisferios; de ellas unas 15 corresponden a la América del Sur. Es un género emparentado con los trigos, habiendo sido considerado a menudo como representante salvaje de ellos. La hibridación entre especies de ambos géneros ha sido realizada por varios investigadores con resultados interesantes; siendo presumible que nuevos ensayos con otras especies puedan aportar más novedades de interés teórico o de valor práctico.Tal circunstancia y el deseo de contribuir al mejor conocimiento denuestra Flora, justificarán la publicación de este estudio en el que he tratado de poner en claro el valor de las especies y variedades, y el área que ocupan en los países más australes de la América del Sur.Facultad de Ciencias Naturales y Muse

Contribución al estudio de las gramíneas del género Munroa

El género Munroa fue establecido por J. Torrey en 1856 basándose en Crypsis squarrosa, especie descrita por T. Nuttall en 1818, pero asignada indebidamente a dicho género. En 1870, R. A. Philippi enriqueció el género con una nueva especie originaria de Mendoza, y en 1891, agregó tres más originarias del norte de Chile. Munroa argentina fue descrita por Grisebach en 1879, basándose en dos ejemplares de procedencia argentina, pero, desgraciadamente pertenecientes a dos especies de distintos géneros: uno de ellos una verdadera Munroa que coincide con la descripción original, y el otro, una especie que llamó la atención de Bentham y Hooker, quienes, en su Genera plantarum hicieron resaltar los caracteres más notables en una breve descripción, mas, sin denominarla: esta descripción dio motivo a que Hackel, algunos años más tarde (1898), la designara Munroa Benthamiana, sin notar sin embargo, que ella pertenecía a otro género. Fue A. S. Hitchcock que en 1920, reconoció el verdadero parentesco de esta gramínea, que durante muchos años quedó confundida entre las especies del género Munroa, refiriéndola al género Blepharidachne, designándola por consiguiente, B. Benthamiana.Facultad de Ciencias Naturales y Muse

¿Qué modelos epistemológicos subyacen en la enseñanza del álgebra universitaria?

En el marco de un proyecto de investigación analizamos las dificultades del estudio del álgebra en el nivel universitario tomando como marco teórico la teoría antropológica de lo didáctico. Creemos que uno de los factores que intervienen en el fracaso podría ser la existencia, dentro de las instituciones, de un modelo epistemológico dominante (MED), que condiciona la tarea docente y provoca cierta desarticulación e incomprensión en los estudiantes. En este trabajo mostramos la experiencia realizada con el fin de indagar acerca del nivel de algebrización alcanzado por alumnos de segundo año del profesorado de matemática de la Universidad Nacional de La Pampa (UNLPam). El resultado de dicha experiencia indica que los estudiantes de la cohorte estudiada no han alcanzado una modelización funcional incluida en el tercer nivel de algebrización

Impact-based flash-flood forecasting system: Sensitivity to high resolution numerical weather prediction systems and soil moisture

In recent years, continuous improvements have been made in weather forecasting and flood prediction with great benefit from Early Warning Systems (EWSs). Despite the continuous quest for innovation from the scientific and user communities, EWSs remain based mostly on hazard forecast, and the information on possible consequences and potential impacts is generally missing. In this work, a methodology for quantitative real-time impact assessment for flash floods is presented. The methodology uses a multi-model ensemble approach and considers soil moisture uncertainty. Moreover, the flood forecasting chain, which normally provides only the discharge probability of exceeding a given threshold, is extended to include a fully 2D hydraulic model and a damage estimation model to quantitatively assess impacts in terms of economic losses and the people involved. The procedure was tested on recent flood events occurring in Genoa in northwestern Italy. This paper discusses the potential challenges and opportunities offered by this approach in the decision-making workflow in an operational context

Parameter space exploration within dynamic simulations of signaling networks

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Functional Neuromyofascial Activity: Interprofessional Assessment to Inform Person-Centered Participative Care-An Osteopathic Perspective

: Introduction: Health professionals and bodyworkers may be pivotal in promoting prevention programs, providing tailored advice and guidance to patients' adherence to self-care strategies, such as physical activity. Contemporary evidence encourages manual therapists to involve patients in decision-making and treatment procedures integrating passive and active approaches in treatment planning. This manuscript provides a definition and applications of neuromyofascial movement patterns, discusses the significance of functional assessment, and gives an example of clinical applications in the osteopathic field to highlight how this assessment can promote interdisciplinarity. Methods: The reporting framework used in the current manuscript followed guidelines for writing a commentary. Results: The manuscript highlights the crucial role that the neuromyofascial system plays in human movement and overall well-being and the importance of a functional neuromyofascial activity assessment in the context of person-centered participative care. Conclusions: Understanding individual neuromyofascial patterns could help healthcare practitioners, movement specialists, and bodyworkers in tailoring treatment plans, meeting patients' unique needs, and promoting a more effective personalized approach to care. The current perspective could spark debates within the professional community and provide a research roadmap for developing an evidence-informed interprofessional framework

Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial

Current colorectal cancer (CRC) treatment guidelines are primarily based on clinical features, such as cancer stage and grade. However, outcomes may be improved using molecular treatment guidelines. Potentially useful biomarkers include driver mutations and somatically inherited alterations, signaling proteins (their expression levels and (post) translational modifications), mRNAs, micro-RNAs and long noncoding RNAs. Moving to an integrated system is potentially very relevant. To implement such an integrated system: we focus on an important region of the signaling network, immediately above the G1-S restriction point, and discuss the reconstruction of a Molecular Interaction Map and interrogating it with a dynamic mathematical model. Extensive model pretraining achieved satisfactory, validated, performance. The model helps to propose future target combination priorities, and restricts drastically the number of drugs to be finally tested at a cellular, in vivo, and clinical-trial level. Our model allows for the inclusion of the unique molecular profiles of each individual patient's tumor. While existing clinical guidelines are well established, dynamic modeling may be used for future targeted combination therapies, which may progressively become part of clinical practice within the near future. WIREs Syst Biol Med 2016, 8:314\u2013336. doi: 10.1002/wsbm.1342. For further resources related to this article, please visit the WIREs website

First diagnosis of multisystem inflammatory syndrome in children (MIS-C): an analysis of PoCUS findings in the ED

Children with multisystem inflammatory syndrome (MIS-C) tend to develop a clinical condition of fluid overload due both to contractile cardiac pump deficit and to endotheliitis with subsequent capillary leak syndrome. In this context, the ability of point-of-care ultrasound (PoCUS) to simultaneously explore multiple systems and detect polyserositis could promote adequate therapeutic management of fluid balance. We describe the PoCUS findings in a case-series of MIS-C patients admitted to the Emergency Department. At admission 10/11 patients showed satisfactory clinical condition without signs and symptoms suggestive for cardiovascular impairment/shock, but PoCUS showed pathological findings in 11/11 (100%). In particular, according to Rapid Ultrasound in SHock (RUSH) protocol, cardiac hypokinesis was detected in 5/11 (45%) and inferior vena cava dilatation in 3/11 (27%). Peritoneal fluid was reported in 6/11 cases (54%). Lung ultrasound (LUS) evaluation revealed an interstitial syndrome in 11/11 (100%), mainly localized in posterior basal lung segments. We suggest PoCUS as a useful tool in the first evaluation of children with suspected MIS-C for the initial therapeutic management and the following monitoring of possible cardiovascular deterioration

HO-1 up-regulation: a key point in high-risk neuroblastoma resistance to bortezomib.

AbstractHigh-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the antioxidant and detoxifying ability of cancer cells, in this study we have investigated their role in differently aggressive NB cell lines treated with BTZ, focusing on the modulation of HO-1 to improve sensitivity to therapy. We have shown that MYCN amplified HTLA-230 cells were slightly sensitive to BTZ treatment, due to the activation of Nrf2 that led to an impressive up-regulation of HO-1. BTZ-treated HTLA-230 cells down-regulated p53 and up-regulated p21, favoring cell survival. The inhibition of HO-1 activity obtained by Zinc (II) protoprophyrin IX (ZnPPIX) was able to significantly increase the pro-apoptotic effect of BTZ in a p53- and p21-independent way. However, MYCN non-amplified SH-SY5Y cells showed a greater sensitivity to BTZ in relation to their inability to up-regulate HO-1. Therefore, we have shown that HO-1 inhibition improves the sensitivity of aggressive NB to proteasome inhibition-based therapy, suggesting that HO-1 up-regulation can be used as a marker of chemoresistance in NB. These results open up a new scenario in developing a combined therapy to overcome chemoresistance in high-risk neuroblastoma

New OCT and OCTA Insights in Inherited Retinal Dystrophies

Optical coherence tomography (OCT) and OCT angiography (OCTA) radically changed the diagnostics of inherited retinal dystrophies (IRD), providing new information regarding the microstructural changes occurring in each disease. The introduction of quantitative metrics provided even more steps forward in the understanding of IRD pathogenesis and course, allowing to propose new ways to categorize different subgroups of patients, characterized by remarkably different characteristics and prognosis. All these informations provided insights regarding how heterogeneous the clinical spectrum of IRD is. In the present study, we provide an updated description of OCT and OCTA findings in the main IRD, including retinitis pigmentosa, Stargardt disease, and Best vitelliform macular dystrophy. Moreover, we discuss imaging findings in pigmented paravenous retinochoroidal atrophy, a rare condition that is undergoing even growing scientific and clinical interest. In addition, we provided a brief updated scenario on imaging findings in pattern dystrophies. We discuss in detail the current state-of-the-art and the new insights provided by quantitative OCT and OCTA approaches, offering a complete description that might be helpful both for expert and nonexpert researchers interested in IRD