A longitudinal study of abnormalities on MRI and disability from multiple sclerosis

Background: In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of the brain increases the likelihood that multiple sclerosis will develop. We sought to determine the relation between early lesion volume, changes in volume, and long-term disability. Methods: Seventy-one patients in a serial MRI study of patients with isolated syndromes were reassessed after a mean of 14.1 years. Disability was measured with the use of Kurtzke's Expanded Disability Status Scale (EDSS; possible range, 0 to 10, with a higher score indicating a greater degree of disability). Results: Clinically definite multiple sclerosis developed in 44 of the 50 patients (88 percent) with abnormal results on MRI at presentation and in 4 of 21 patients (19 percent) with normal results on MRI. The median EDSS score at follow-up for those with multiple sclerosis was 3.25 (range, 0 to 10); 31 percent had an EDSS score of 6 or more (including three patients whose deaths were due to multiple sclerosis). The EDSS score at 14 years correlated moderately with lesion volume on MRI at 5 years (r=0.60) and with the increase in lesion volume over the first 5 years (r=0.61). Conclusions: In patients who first present with isolated syndromes suggestive of multiple sclerosis, the increases in the volume of the lesions seen on magnetic resonance imaging of the brain in the first five years correlate with the degree of long-term disability from multiple sclerosis. This relation is only moderate, so the volume of the lesions alone may not be an adequate basis for decisions about the use of disease-modifying treatment

The P Cygni supergiant [OMN2000] LS1 – implications for the star formation history of W51

Original article can be found at: http://www.aanda.org/ Copyright The European Southern Observatory (ESO) DOI: 10.1051/0004-6361/200911980Aims. We investigate the nature of the massive star [OMN2000] LS1 and use these results to constrain the history of star formation within the host complex W51. Methods. We utilised a combination of near-IR spectroscopy and non-LTE model atmosphere analysis to derive the physical properties of [OMN2000] LS1 , and a combination of theoretical evolutionary calculations and Monte Carlo simulations to apply limits on the star formation history of W51. Results. We find the spectrum of [OMN2000] LS1 to be consistent with that of a P Cygni supergiant. With a temperature in the range of 13.2–13.7 kK and log( ) , it is significantly cooler, less luminous, and less massive than proposed by previous authors. The presence of such a star within W51 shows that star formation has been underway for at least 3 Myr, while the formation of massive O stars is still on going. The lack of a population of evolved red supergiants within the complex shows that the rate of formation of young massive clusters at ages 9 Myr was lower than currently observed. We find no evidence of internally triggered, sequential star formation within W51, and favour the suggestion that star formation has proceeded at multiple indepedent sites within the GMC. Along with other examples, such as the G305 and Carina star-forming regions, we suggest that W51 is a Galactic analogue of the ubiquitous star cluster complexes seen in external galaxies such as M51 and NGC2403.Peer reviewe

Physical and chemical signatures of a developing anticyclonic eddy in the Leeuwin Current, eastern Indian Ocean

A multidisciplinary cruise aboard the R/V Southern Surveyor was conducted in May 2006 to sample a developing anticyclonic eddy of the Leeuwin Current off Western Australia. The eddy formed from a meander of the Leeuwin Current in mid-April 2006 and remained attached to the current until mid-August. In this study, a combination of satellite data (altimeter, sea surface temperature, and chlorophyll a) and shipboard measurements (acoustic Doppler current profiler and conductivity-temperature-depth) were used to characterize the physical and chemical signatures of the eddy. The temperature-salinity properties of the mixed layer waters within the anticyclonic eddy and on the shelf were both connected to that of the Leeuwin Current, indicating the water mass in the eddy is mainly derived from the Leeuwin Current and the modified Leeuwin Current water on the shelf. Above the salinity maximum near the eddy center, there was a regionally significant concentration of nitrate (>0.9 μmol L-1), and the maximum (2 μmol L-1) was at 150 in depth, below the photic zone. Nitrification within the eddy and/or local upwelling due to the forming eddy could be responsible for this high concentration of nitrate near the eddy center which potentially makes the eddy a relatively productive feature in the Leeuwin Current

Molecular scale contact line hydrodynamics of immiscible flows

From extensive molecular dynamics simulations on immiscible two-phase flows, we find the relative slipping between the fluids and the solid wall everywhere to follow the generalized Navier boundary condition, in which the amount of slipping is proportional to the sum of tangential viscous stress and the uncompensated Young stress. The latter arises from the deviation of the fluid-fluid interface from its static configuration. We give a continuum formulation of the immiscible flow hydrodynamics, comprising the generalized Navier boundary condition, the Navier-Stokes equation, and the Cahn-Hilliard interfacial free energy. Our hydrodynamic model yields interfacial and velocity profiles matching those from the molecular dynamics simulations at the molecular-scale vicinity of the contact line. In particular, the behavior at high capillary numbers, leading to the breakup of the fluid-fluid interface, is accurately predicted.Comment: 33 pages for text in preprint format, 10 pages for 10 figures with captions, content changed in this resubmissio

Asymptotic Giant Branch Variables in the Galaxy and the Local Group

AGB variables, particularly the large amplitude Mira type, are a vital step on the distance scale ladder. They will prove particularly important in the era of space telescopes and extremely large ground-based telescopes with adaptive optics, which will be optimized for infrared observing. Our current understanding of the distances to these stars is reviewed with particular emphasis on improvements that came from Hipparcos as well as on recent work on Local Group galaxies. In addition to providing the essential calibration for extragalactic distances Gaia may also provide unprecedented insight into the poorly understood mass-loss process itself.Comment: Accepted for publication in Astrophysics and Space Science. From a presentation at the conference "The Fundamental Cosmic Distance Scale: State of the Art and Gaia Perspective, Naples May 2011. 8 Pages, 9 Figure

New directions in agricultural information systems and services for development : some practical observations

Meeting: Reunión Interamericana de Bibliotecarios y Documentalistas Agrícolas, 2-7 dic. 1990, San José, CRIncludes abstract in Spanis

Data acquisition for PLT

DA/PLT, the data acquisition system for the Princeton Large Torus (PLT) fusion research device, consists of a PDP-10 host computer, five satellite PDP- 11s connected to the host by a special high-speed interface, miscellaneous other minicomputers and commercially supplied instruments, and much PPPL produced hardware. The software consists of the standard PDP-10 monitor with local modifications and the special systems and applications programs to customize the DA/PLT for the specific job of supporting data acquisition, analysis, display, and archiving, with concurrent off-line analysis, program development, and, in the background, general batch and timesharing. Some details of the over-all architecture are presented, along with a status report of the different PLT experiments being supported. (auth

Shear-dependent apparent slip on hydrophobic surfaces: The Mattress Model

Recent experiments (Zhu & Granick (2001) Phys. Rev. Lett. 87 096105) have measured a large shear dependent fluid slip at partially wetting fluid-solid surfaces. We present a simple model for such slip, motivated by the recent observations of nanobubbles on hydrophobic surfaces. The model considers the dynamic response of bubbles to change in hydrodynamic pressure due to the oscillation of a solid surface. Both the compression and diffusion of gas in the bubbles decrease the force on the oscillating surface by a ``leaking mattress'' effect, thereby creating an apparent shear-dependent slip. With bubbles similar to those observed by atomic force microscopy to date, the model is found to lead to force decreases consistent with the experimental measurements of Zhu & Granick

Ant colony optimisation for planning safe escape routes

An emergency requiring evacuation is a chaotic event filled with uncertainties both for the people affected and rescuers. The evacuees are often left to themselves for navigation to the escape area. The chaotic situation increases when a predefined escape route is blocked by a hazard, and there is a need to re-think which escape route is safest. This paper addresses automatically finding the safest escape route in emergency situations in large buildings or ships with imperfect knowledge of the hazards. The proposed solution, based on Ant Colony Optimisation, suggests a near optimal escape plan for every affected person — considering both dynamic spread of hazards and congestion avoidance.The solution can be used both on an individual bases, such as from a personal smart phone of one of the evacuees, or from a remote location by emergency personnel trying to assist large groups