Oligo-astrocytoma in LZTR1-related Noonan syndrome

Mutations in LZTR1, already known to be causal in familial schwannomatosis type 2, have been recently involved in a small proportion of patients with autosomal dominant and autosomal recessive Noonan syndrome. LZTR1 is also a driver gene in non syndromal glioblastoma. We report a 26-year-old patient with typical Noonan syndrome, and the dominantly transmitted c.850C > T (p.(Arg284Cys)) variant in LZTR1. An oligoastrocytoma was diagnosed in the patient at the age of 22 years; recurrence of the tumor occurred at age 26, as a ganglioblastoma. The patient had been transiently treated with growth hormone between ages 15 and 17. Considering the implication of LZTR1 in sporadic tumors of the nervous system, we hypothesize that gliomas are a possible complication of LZTR1-related Noonan syndrome. This report also supports a possible link between occurrence of a cerebral tumor in Noonan syndrome and a previous treatment with growth hormone

The PHEMU03 catalogue of observations of the mutual phenomena of the Galilean satellites of Jupiter

International audienc

A catalogue of the observations of the mutual phenomena of the Galilean satellites made in 1991 during the PHEMU91 campaign

In this paper, all the light-curves obtained during the PHEMU91 campaign of observations of the mutual phenomena of the Galilean satellites are presented. These observations give accurate astrometric positions of major interest for dynamical studies of the motion of the Galilean satellites. The aim of this work is to give observational data directly usable for theoretical studies. We made 374 observations of 111 mutual events from 56 sites. The corresponding data are given in this paper. The accuracy of each observation has been deduced from a comparison with the theoretical predictions. For each observation, information is given about the telescope, the receptor, the site and the observational conditions