60 research outputs found

    One-dimensional approximate technique for earth penetration calculations

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    The penetration process is approximated by the one-dimensional expansion of a cylindrical cavity in an infinite solid. Linear and quadratic forms are used to describe, piecewise, the volumetric response of the target during loading at the shock front. It is assumed that the density locks at the shocked state. The shear strength of the target is taken to be a piecewise linear function of pressure. However, it is assumed that the target material is weak in shear and, thus, that the effect of shear strength can be treated as a perturbation on the hydrodynamic solution. For conical-nosed penetrators an analytic expression for the normal stress results from the analysis, while for ogival-nosed penetrators the solution must be obtained numerically. A computer program, PENAP, was written to treat both the ogive and cone geometry, and PENAP solutions were found to agree well with both experimental data and TOODY, two-dimensional finite-difference wavecode results. It should also be noted that the PENAP calculations typically required several orders of magnitude less computer time than did the TOODY calculations

    International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe

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    In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors’ experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible

    Polyamines and cancer: old molecules, new understanding

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    The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues

    Comparison of experimental and computational results for reverse ballistic tests into foundry core

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    A series of nine laboratory-scale penetration tests was conducted in which impact velocity and geometry of the projectile were varied. In all tests, displacement histories were obtained for the penetrator via displacement interferometric techniques. From the data, accelerations were deduced and compared with numerically-calculated accelerations. For the numerical work, the codes PENAP and WONDY were used to model the penetration events. For penetrators with a conical nose, agreement between calculated and measured accelerations could be brought within 15% for all tests, except for one PENAP/test comparison, by introducing a constant coefficient of Coulomb friction of 0.1 at the penetration target interface. For penetrators with an ogival nose, on the other hand, a greater discrepancy was found between calculated and measured results

    Catalyst and process development for hydrogen preparation from future fuel cell feedstocks. Quarterly progress report, October 1, 1979-December 31, 1979. [Pt/Rh, Ni/Rh, Ni/Pt/Rh, Ni, Ni/Ru, Ni/Pt, Ni/Co]

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    Twelve steam reforming catalysts were evaluated using an autothermal reforming screening unit. Duplicate tests were run with two samples to determine test variability. The samples tested contained either base metals, precious metals, or combinations of base and precious metals. The test was capable of distinguishing among samples where gross variations in composition are the main factor; for example, catalysts containing 2% by weight precious metals are more active than catalysts containing 15% by weight nickel. The results show a decrease in hydrocarbon breakthrough as the weight of nickel charged to the constant volume reactor increases. A commercial nickel catalyst, G90C, appears slightly better than some Engelhard prepared samples of equal nickel concentrations due to the higher density of G90C. Visual observation of the used catalysts show that samples containing only precious metals (Pt/Rh) did not coke during the run. The samples containing only base metals (nickel, cobalt) were coked and were magnetic. Samples containing 14.5% nickel by weight with 0.5% precious metals by weight added were not coked, were not magnetic, and had a blue colored core as compared to the black core of the virgin samples. Some speculation about deactivation mechanisms based on these observations are made

    Catalyst and process development for the H/sub 2/ preparation from future fuel cell feedstocks. Quarterly progress report, October 1, 1978-December 31, 1978

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    The work done under this contract in the last quarter of 1978 was concerned with Phase I, which involved preliminary catalyst and process evaluation. The processes under study are hydrogen assisted steam reforming (HASR), catalytic partial oxidation (CPO), and autothermal steam reforming (ATR). Existing Engelhard test units were modified to carry out preliminary runs using the first two processes. Technical analysis to support work in this area consisted of heat and material balances constrained by equilibrium considerations. In a third task, the steam reforming of methanol to produce hydrogen was studied over two commercial low-temperature shift catalysts. Aging runs indicated good initial performance on both catalysts, but methanol conversion started to decline after a few hundred hours on stream
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