717 research outputs found
The first joint ESGAR/ ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging
Objectives: To develop guidelines describing a standardised approach to patient preparation and acquisition protocols for magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) of the small bowel and colon, with an emphasis on imaging inflammatory bowel disease. Methods: An expert consensus committee of 13 members from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Paediatric Radiology (ESPR) undertook a six-stage modified Delphi process, including a detailed literature review, to create a series of consensus statements concerning patient preparation, imaging hardware and image acquisition protocols. Results: One hundred and fifty-seven statements were scored for agreement by the panel of which 129 statements (82 %) achieved immediate consensus with a further 19 (12 %) achieving consensus after appropriate modification. Nine (6 %) statements were rejected as consensus could not be reached. Conclusions: These expert consensus recommendations can be used to help guide cross-sectional radiological practice for imaging the small bowel and colon. Key points: ⢠Cross-sectional imaging is increasingly used to evaluate the bowel ⢠Image quality is paramount to achieving high diagnostic accuracy ⢠Guidelines concerning patient preparation and image acquisition protocols are provided
Person-Centred Therapists Call on SCoPEd Partners to Offer PSA-Backed Membership Home for those Opposed to Framework
A group of prominent practitioners, writers, trainers and academics from the Person-Centred community in the UK, along with two organisations, have published an open letter calling on the SCoPEd organisations to provide a professional home on their PSA-backed registers for members who do not wish to be aligned with SCoPEdâs divisive and hierarchical framework
In situ characterization of the decomposition behavior of Mg(BH4)(2) by X-ray Raman scattering spectroscopy
We present an in situ study of the thermal decomposition of Mg(BH4)(2) in a hydrogen atmosphere of up to 4 bar and up to 500 degrees C using X-ray Raman scattering spectroscopy at the boron K-edge and the magnesium L2,3-edges. The combination of the fingerprinting analysis of both edges yields detailed quantitative information on the reaction products during decomposition, an issue of crucial importance in determining whether Mg(BH4)(2) can be used as a next-generation hydrogen storage material. This work reveals the formation of reaction intermediate(s) at 300 degrees C, accompanied by a significant hydrogen release without the occurrence of stable boron compounds such as amorphous boron or MgB12H12. At temperatures between 300 degrees C and 400 degrees C, further hydrogen release proceeds via the formation of higher boranes and crystalline MgH2. Above 400 degrees C, decomposition into the constituting elements takes place. Therefore, at moderate temperatures, Mg(BH4)(2) is shown to be a promising high-density hydrogen storage material with great potential for reversible energy storage applications.Peer reviewe
IntAct:intra-operative fluorescence angiography to prevent anastomotic leak in rectal cancer surgery: a randomized controlled trial
Aim
Anastomotic leak (AL) is a major complication of rectal cancer surgery. Despite advances in surgical practice, the rates of AL have remained static, at around 10â15%. The aetiology of AL is multifactorial, but one of the most crucial risk factors, which is mostly under the control of the surgeon, is blood supply to the anastomosis. The MRC/NIHR IntAct study will determine whether assessment of anastomotic perfusion using a fluorescent dye (indocyanine green) and nearâinfrared laparoscopy can minimize the rate of AL leak compared with conventional whiteâlight laparoscopy. Two mechanistic subâstudies will explore the role of the rectal microbiome in AL and the predictive value of CT angiography/perfusion studies.
Method
IntAct is a prospective, unblinded, parallelâgroup, multicentre, European, randomized controlled trial comparing surgery with intraâoperative fluorescence angiography (IFA) against standard care (surgery with no IFA). The primary endâpoint is rate of clinical AL at 90 days following surgery. Secondary endâpoints include all AL (clinical and radiological), change in planned anastomosis, complications and reâinterventions, use of stoma, costâeffectiveness of the intervention and quality of life. Patients should have a diagnosis of adenocarcinoma of the rectum suitable for potentially curative surgery by anterior resection. Over 3 years, 880 patients from 25 European centres will be recruited and followed up for 90 days.
Discussion
IntAct will rigorously evaluate the use of IFA in rectal cancer surgery and explore the role of the microbiome in AL and the predictive value of preoperative CT angiography/perfusion scanning
BICEP2 II: Experiment and Three-Year Data Set
We report on the design and performance of the BICEP2 instrument and on its
three-year data set. BICEP2 was designed to measure the polarization of the
cosmic microwave background (CMB) on angular scales of 1 to 5 degrees
(=40-200), near the expected peak of the B-mode polarization signature of
primordial gravitational waves from cosmic inflation. Measuring B-modes
requires dramatic improvements in sensitivity combined with exquisite control
of systematics. The BICEP2 telescope observed from the South Pole with a 26~cm
aperture and cold, on-axis, refractive optics. BICEP2 also adopted a new
detector design in which beam-defining slot antenna arrays couple to
transition-edge sensor (TES) bolometers, all fabricated on a common substrate.
The antenna-coupled TES detectors supported scalable fabrication and
multiplexed readout that allowed BICEP2 to achieve a high detector count of 500
bolometers at 150 GHz, giving unprecedented sensitivity to B-modes at degree
angular scales. After optimization of detector and readout parameters, BICEP2
achieved an instrument noise-equivalent temperature of 15.8 K sqrt(s). The
full data set reached Stokes Q and U map depths of 87.2 nK in square-degree
pixels (5.2 K arcmin) over an effective area of 384 square degrees within
a 1000 square degree field. These are the deepest CMB polarization maps at
degree angular scales to date. The power spectrum analysis presented in a
companion paper has resulted in a significant detection of B-mode polarization
at degree scales.Comment: 30 pages, 24 figure
Standardised reports with a template format are superior to free text reports: the case for rectal cancer reporting in clinical practice
Purpose: Rectal cancer staging with magnetic resonance imaging (MRI) allows accurate assessment and preoperative staging of rectal cancers. Therefore, complete MRI reports are vital to treatment planning. Significant variability may exist in their content and completeness. Template-style reporting can improve reporting standards, but its use is not widespread. Given the implications for treatment, we have evaluated current clinical practice amongst specialist gastrointestinal (GI) radiologists to measure the quality of rectal cancer staging MRI reports.
Materials and methods: Sixteen United Kingdom (UK) colorectal cancer multi-disciplinary teams (CRC-MDTs) serving a population over 5 million were invited to submit up to 10 consecutive rectal cancer primary staging MRI reports from January 2016 for each radiologist participating in the CRC-MDT. Reports were compared to a reference standard based on recognised staging and prognostic factors influencing case management
Results: Four hundred ten primary staging reports were submitted from 41 of 42 (97.6%) eligible radiologists. Three hundred sixty reports met the inclusion criteria, of these, 81 (22.5%) used a template. Template report usage significantly increased recording of key data points versus non-template reports for extra-mural venous invasion (EMVI) status (98.8% v 51.6%, pâ<â0.01) and circumferential resection margin (CRM) status (96.3% v 65.9%, pâ<â0.01). Local tumour stage (97.5% v 93.5%, NS) and nodal status (98.8% v 96.1%, NS) were reported and with similar frequency.
Conclusion: Rectal cancer primary staging reports do not meet published standards. Template-style reports have significant increases in the inclusion of key tumour descriptors. This study provides further support for their use to improve reporting standards and outcomes in rectal cancer
BICEP2 / Keck Array V: Measurements of B-mode Polarization at Degree Angular Scales and 150 GHz by the Keck Array
The Keck Array is a system of cosmic microwave background (CMB) polarimeters,
each similar to the BICEP2 experiment. In this paper we report results from the
2012 and 2013 observing seasons, during which the Keck Array consisted of five
receivers all operating in the same (150 GHz) frequency band and observing
field as BICEP2. We again find an excess of B-mode power over the
lensed-CDM expectation of in the range
and confirm that this is not due to systematics using jackknife tests and
simulations based on detailed calibration measurements. In map difference and
spectral difference tests these new data are shown to be consistent with
BICEP2. Finally, we combine the maps from the two experiments to produce final
Q and U maps which have a depth of 57 nK deg (3.4 K arcmin) over an
effective area of 400 deg for an equivalent survey weight of 250,000
K. The final BB band powers have noise uncertainty a factor of 2.3
times better than the previous results, and a significance of detection of
excess power of .Comment: 13 pages, 9 figure
Antenna-coupled TES bolometers used in BICEP2, Keck array, and SPIDER
We have developed antenna-coupled transition-edge sensor (TES) bolometers for
a wide range of cosmic microwave background (CMB) polarimetry experiments,
including BICEP2, Keck Array, and the balloon borne SPIDER. These detectors
have reached maturity and this paper reports on their design principles,
overall performance, and key challenges associated with design and production.
Our detector arrays repeatedly produce spectral bands with 20%-30% bandwidth at
95, 150, or 220~GHz. The integrated antenna arrays synthesize symmetric
co-aligned beams with controlled side-lobe levels. Cross-polarized response on
boresight is typically ~0.5%, consistent with cross-talk in our multiplexed
readout system. End-to-end optical efficiencies in our cameras are routinely
35% or higher, with per detector sensitivities of NET~300 uKrts. Thanks to the
scalability of this design, we have deployed 2560 detectors as 1280 matched
pairs in Keck Array with a combined instantaneous sensitivity of ~9 uKrts, as
measured directly from CMB maps in the 2013 season. Similar arrays have
recently flown in the SPIDER instrument, and development of this technology is
ongoing.Comment: 16 pgs, 20 fig
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