Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs

Data availability. The RNA sequencing dataset is available at EBI (www.ebi.ac.uk/arrayexpress/) under accession number E-MTAB-5990. Other data that support the findings of this study are available from the corresponding author upon reasonable request. ACKNOWLEDGMENTS We thank Debbie Smith for constructing the strains JC41 and JC310, Arnab Pradhan for help with DHE control experiments, and our colleagues in the Aberdeen Fungal Group and Newcastle Yeast Group for insightful discussions. We are also grateful to Mike Gustin for his advice. We are grateful to the Centre for Genome Enabled Biology and Medicine, Aberdeen Proteomics, the Iain Fraser Cytometry Centre, the Microscopy and Histology Facility, and the qPCR facility at the University of Aberdeen for their help, advice, and support. This work was funded by the UK Biotechnology and Biological Research Council (http://www.bbsrc.ac.uk) (grants BB/K017365/1 and BB/F00513X/1 to A.J.P.B. and grant BB/K016393/1 to J.Q.). This work was also supported by the European Research Council (http://erc.europa.eu/) (STRIFE advanced grant C-2009-AdG-249793 to A.J.P.B.), the UK Medical Research Council (http://www.mrc.ac.uk) (grant MR/M026663/1 to A.J.P.B. and grant MR/M000923/1 to P.S.S.), the Wellcome Trust (https://wellcome.ac.uk) (grant 097377 to A.J.P.B. and J.Q.), the MRC Centre for Medical Mycology and the University of Aberdeen (grant MR/M026663/1 to A.J.P.B.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

The RMS Survey: The Bolometric Fluxes and Luminosity Distributions of Young Massive Stars

Context: The Red MSX Source (RMS) survey is returning a large sample of massive young stellar objects (MYSOs) and ultra-compact (UC) \HII{} regions using follow-up observations of colour-selected candidates from the MSX point source catalogue. Aims: To obtain the bolometric fluxes and, using kinematic distance information, the luminosities for young RMS sources with far-infrared fluxes. Methods: We use a model spectral energy distribution (SED) fitter to obtain the bolometric flux for our sources, given flux data from our work and the literature. The inputs to the model fitter were optimised by a series of investigations designed to reveal the effect varying these inputs had on the resulting bolometric flux. Kinematic distances derived from molecular line observations were then used to calculate the luminosity of each source. Results: Bolometric fluxes are obtained for 1173 young RMS sources, of which 1069 have uniquely constrained kinematic distances and good SED fits. A comparison of the bolometric fluxes obtained using SED fitting with trapezium rule integration and two component greybody fits was also undertaken, and showed that both produce considerable scatter compared to the method used here. Conclusions: The bolometric flux results allowed us to obtain the luminosity distributions of YSOs and UC\HII{} regions in the RMS sample, which we find to be different. We also find that there are few MYSOs with L $\geq$ 10$^{5}$\lsol{}, despite finding many MYSOs with 10$^{4}$\lsol{} $\geq$ L $\geq$ 10$^{5}$\lsol{}.Comment: 12 pages, 12 figures, 3 tables, accepted to A&A. The full versions of tables 1 and 2 will be available via the CDS upon publicatio

Failure time and microcrack nucleation

The failure time of samples of heterogeneous materials (wood, fiberglass) is studied as a function of the applied stress. It is shown that in these materials the failure time is predicted with a good accuracy by a model of microcrack nucleation proposed by Pomeau. It is also shown that the crack growth process presents critical features when the failure time is approached.Comment: 13 pages, 4 figures, submitted to Europhysics Letter

The case for the use of multiple imputation missing data methods in stochastic frontier analysis with illustration using English local highway data

Multiple Imputation (MI) methods have been widely applied in economic applications as a robust statistical way to incorporate data where some observations have missing values for some variables. However in Stochastic Frontier Analysis (SFA), application of these techniques has been sparse and the case for such models has not received attention in the appropriate academic literature. This paper fills this gap and explores the robust properties of MI within the stochastic frontier context. From a methodological perspective, we depart from the standard MI literature by demonstrating, conceptually and through simulation, that it is not appropriate to use imputations of the dependent variable within the SFA modelling, although they can be useful to predict the values of missing explanatory variables. Fundamentally, this is because efficiency analysis involves decomposing a residual into noise and inefficiency and as a result any imputation of a dependent variable would be imputing efficiency based on some concept of average inefficiency in the sample. A further contribution that we discuss and illustrate for the first time in the SFA literature, is that using auxiliary variables (outside of those contained in the SFA model) can enhance the imputations of missing values. Our empirical example neatly articulates that often the source of missing data is only a sub-set of components comprising a part of a composite (or complex) measure and that the other parts that are observed are very useful in predicting the value

Occupational therapy students’ use of social media for professional practice

Background. The use of social media for professional practice is an emerging trend for healthcare professionals; however, limited literature exists on the phenomenon. Social media usage is prevalent among students, as it is incorporated into many health professions education curricula. This poses potential ethical dilemmas.Objective. To examine the nature of social media usage and knowledge of ethical considerations by occupational therapy (OT) students for professional purposes.Methods. A quantitative, cross-sectional survey was administered to the entire cohort of OT students (N=128) enrolled at the University of KwaZulu-Natal, Durban, South Africa in 2016. Data were analysed descriptively using Microsoft Excel 2013 (Microsoft, USA).Results. The most commonly used device to access social media was mobile phones, with WhatsApp and YouTube frequently used for both general and professional purposes. Uses included accessing social media for developing professional skills and knowledge, and in fulfilling academic requirements. Ethical dilemmas were evident among students, who indicated that social media ethical considerations should be incorporated into the curriculum.Conclusion. The study highlighted that most students use some form of social media as part of their professional practice, which has the potential to be used effectively to enhance learning opportunities. Future studies of a qualitative nature could shed light on students’ perceptions of social media and practical implications for practice

Enhanced smoking cessation support for newly abstinent smokers discharged from hospital (The Hospital to Home trial): A randomised controlled trial

Background and aimsThe United Kingdom's National Institute for Health and Care Excellence guidance (NICE PH48) recommends that pharmacotherapy combined with behavioural support be provided for all smokers admitted to hospital; however, relapse to smoking after discharge remains common. This study aimed to assess the effect of adding home support for newly?abstinent smokers to conventional NICE?recommended support in smokers discharged from hospital.Designindividually?randomised parallel group trial.SettingOne UK acute hospital.Participants404 smokers aged >18 admitted to acute medical wards between June 2016 and July 2017 were randomised in equal numbers to each treatment group.Interventions and comparatorsThe intervention provided 12 weeks of at?home cessation support which included help in maintaining a smoke?free home, help in accessing and using medication, further behavioural support and personalised feedback on home air quality. The comparator was NICE PH48 care as usual.MeasuresThe primary outcome was self?reported continuous abstinence from smoking validated by an exhaled carbon monoxide level ?6ppm four?weeks after discharge from hospital.FindingsIn an intention?to?treat analysis at the four?week primary endpoint, 38 participants (18.8%) in the usual care group and 43 (21.3%) in the intervention group reported continuous abstinence from smoking (odds ratio 1.17, 95% confidence interval 0.72 to 1.90, Bayes factor 0.33). There were no significant differences in any secondary outcomes, including self?reported cessation at 3 months, having a smoke?free home, or number of cigarettes smoked per day in those who did not quit.ConclusionsProvision of a home visit and continued support to prevent relapse to smoking after hospital discharge did not appear to increase subsequent abstinence rate above usual care in accordance with UK guidance from the National Institute of Health and Care Excellence

International experience of public infrastructure delivery in support of housing growth

This paper compares planning and funding arrangements for public infrastructure delivery in support of new housing development in the UK, Australia, Germany, the Netherlands, Canada, the US, and Hong Kong/Mainland China. It examines the roles and responsibilities of different levels of government, the extraction of financial contributions from the development process (mainly funded through increases in land value), and the level of involvement of private and public actors in infrastructure delivery and land value capture (LVC). Three linked questions provide a basis for comparison of the cases: first, what arrangements are in place, in terms of planning hierarchy and responsibility, for coordinating infrastructure delivery (and how do these relate to funding arrangements); second, how are local contributions extracted from the development process or through the acquisition and sale of land; and lastly, what inferences can be drawn regarding the relative power of public and private actors in this process and to what extent is public interest prioritized/served through prevailing approaches to value extraction. The paper contributes international experience to debates on optimizing planning approaches for infrastructure delivery while maximizing public benefit from land value