274 research outputs found
Optimizing Associative Information Transfer within Content-addressable Memory
Original article can be found at: http://www.oldcitypublishing.com/IJUC/IJUC.htmlPeer reviewe
EVALUATION OF ANTIOXIDANTS AND MOLECULAR DOCKING STUDIES OF HELICTERES ISORA FRUIT EXTRACTS
The medical plants are widely used by the traditional medicinal practitioners for curing various diseases. The present study aims at evaluate the phytochemical properties and antioxidant sensing activity of the fruit Helicteres Isora. For this the fruit parts of the plant were chosen and extracts were prepared using methanol and ethanol. Phytochemical qualitative screening revealed the presence of compounds such as alkaloids, carbohydrates, glycosides, saponins, proteins, amino acids and flavonoids. The antioxidant activity of the plant extracts were performed by DPPH method.ΓΒ The free radical scavenging activity was measured spectrophotometrically as maximum fading power of DPPH at 517nm. All extracts showed different level of antioxidant activity. Molecular docking studies was also done to study the mechanism of action of the active compounds present in the fruit. Keywords: Helicteres Isora, DPPH assay, FRAP assay, Phytochemicals, Molecular docking
Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes
In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome. Besides the human Y chromosome, both sequences strongly hybridized to the human X chromosome, with few minor binding sites on autosomes. In particular, on the X chromosome DNA from clone YACG 35 hybridized to the centromeric region and the distal part of the short arm (Xp2.2). On the Y chromosome, the sequence was assigned to one site situated in the border region between Yq1.1 and Yq1.2. DNA from clone 2.8 also hybridized to the centromeric region of the X and the distal part of the short arm (Xq2.2). On the Y, however, two binding sites were observed (Yp1.1 and Yq1.2). The findings indicate that sex chromosomal sequences may be localized in homologous regions (as suggested from meiotic pairing) but also at ectopic sites
RoboCup 2D Soccer Simulation League: Evaluation Challenges
We summarise the results of RoboCup 2D Soccer Simulation League in 2016
(Leipzig), including the main competition and the evaluation round. The
evaluation round held in Leipzig confirmed the strength of RoboCup-2015
champion (WrightEagle, i.e. WE2015) in the League, with only eventual finalists
of 2016 competition capable of defeating WE2015. An extended, post-Leipzig,
round-robin tournament which included the top 8 teams of 2016, as well as
WE2015, with over 1000 games played for each pair, placed WE2015 third behind
the champion team (Gliders2016) and the runner-up (HELIOS2016). This
establishes WE2015 as a stable benchmark for the 2D Simulation League. We then
contrast two ranking methods and suggest two options for future evaluation
challenges. The first one, "The Champions Simulation League", is proposed to
include 6 previous champions, directly competing against each other in a
round-robin tournament, with the view to systematically trace the advancements
in the League. The second proposal, "The Global Challenge", is aimed to
increase the realism of the environmental conditions during the simulated
games, by simulating specific features of different participating countries.Comment: 12 pages, RoboCup-2017, Nagoya, Japan, July 201
The Value of Information for Populations in Varying Environments
The notion of information pervades informal descriptions of biological
systems, but formal treatments face the problem of defining a quantitative
measure of information rooted in a concept of fitness, which is itself an
elusive notion. Here, we present a model of population dynamics where this
problem is amenable to a mathematical analysis. In the limit where any
information about future environmental variations is common to the members of
the population, our model is equivalent to known models of financial
investment. In this case, the population can be interpreted as a portfolio of
financial assets and previous analyses have shown that a key quantity of
Shannon's communication theory, the mutual information, sets a fundamental
limit on the value of information. We show that this bound can be violated when
accounting for features that are irrelevant in finance but inherent to
biological systems, such as the stochasticity present at the individual level.
This leads us to generalize the measures of uncertainty and information usually
encountered in information theory
Predicting Player Experience Without the Player. An Exploratory Study
A key challenge of procedural content generation (PCG) is to evoke a certain player experience (PX), when we have no direct control over the content which gives rise to that experience. We argue that neither the rigorous methods to assess PX in HCI, nor specialised methods in PCG are sufficient, because they rely on a human in the loop. We propose to address this shortcoming by means of computational models of intrinsic motivation and AI game-playing agents. We hypothesise that our approach could be used to automatically predict PX across games and content types without relying on a human player or designer. We conduct an exploratory study in level generation based on empowerment, a specific model of intrinsic motivation. Based on a thematic analysis, we find that empowerment can be used to create levels with qualitatively different PX. We relate the identified experiences to established theories of PX in HCI and game design, and discuss next steps
Integrated information increases with fitness in the evolution of animats
One of the hallmarks of biological organisms is their ability to integrate
disparate information sources to optimize their behavior in complex
environments. How this capability can be quantified and related to the
functional complexity of an organism remains a challenging problem, in
particular since organismal functional complexity is not well-defined. We
present here several candidate measures that quantify information and
integration, and study their dependence on fitness as an artificial agent
("animat") evolves over thousands of generations to solve a navigation task in
a simple, simulated environment. We compare the ability of these measures to
predict high fitness with more conventional information-theoretic processing
measures. As the animat adapts by increasing its "fit" to the world,
information integration and processing increase commensurately along the
evolutionary line of descent. We suggest that the correlation of fitness with
information integration and with processing measures implies that high fitness
requires both information processing as well as integration, but that
information integration may be a better measure when the task requires memory.
A correlation of measures of information integration (but also information
processing) and fitness strongly suggests that these measures reflect the
functional complexity of the animat, and that such measures can be used to
quantify functional complexity even in the absence of fitness data.Comment: 27 pages, 8 figures, one supplementary figure. Three supplementary
video files available on request. Version commensurate with published text in
PLoS Comput. Bio
DNA repair, genome stability and cancer: a historical perspective
The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy
Cell Lineage Analysis of the Mammalian Female Germline
Fundamental aspects of embryonic and post-natal development, including maintenance of the mammalian female germline, are largely unknown. Here we employ a retrospective, phylogenetic-based method for reconstructing cell lineage trees utilizing somatic mutations accumulated in microsatellites, to study female germline dynamics in mice. Reconstructed cell lineage trees can be used to estimate lineage relationships between different cell types, as well as cell depth (number of cell divisions since the zygote). We show that, in the reconstructed mouse cell lineage trees, oocytes form clusters that are separate from hematopoietic and mesenchymal stem cells, both in young and old mice, indicating that these populations belong to distinct lineages. Furthermore, while cumulus cells sampled from different ovarian follicles are distinctly clustered on the reconstructed trees, oocytes from the left and right ovaries are not, suggesting a mixing of their progenitor pools. We also observed an increase in oocyte depth with mouse age, which can be explained either by depth-guided selection of oocytes for ovulation or by post-natal renewal. Overall, our study sheds light on substantial novel aspects of female germline preservation and development
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