The effects of isometric work on heart rate, blood pressure, and net oxygen cost

Isometric exercise effects on heart rate, blood pressure, and net oxygen cos

Fumonisins in Conventional and Transgenic, Insect-Resistant Maize Intended for Fuel Ethanol Production: Implications for Fermentation Efficiency and DDGS Co-Product Quality

Mycotoxins in maize grain intended for ethanol production are enriched in co-product dried distiller’s grains and solubles (DDGS) and may be detrimental to yeast in fermentation. This study was conducted to examine the magnitude of fumonisin enrichment in DDGS and to analyze the impacts of insect injury, Fusarium ear rot severity, and fumonisin contamination on final ethanol yield. Samples of naturally-contaminated grain (0 to 35 mg/kg fumonisins) from field trials conducted in 2008–2011 were fermented and DDGS collected and analyzed for fumonisin content. Ethanol yield (determined gravimetrically) was unaffected by fumonisins in the range occurring in this study, and was not correlated with insect injury or Fusarium ear rot severity. Ethanol production was unaffected in fumonisin B1-spiked grain with concentrations from 0 to 37 mg/kg.Bacillus thuringiensis (Bt) maize often has reduced fumonisins due to its protection from insect injury and subsequent fungal infection. DDGS derived from Bt and non-Bt maize averaged 2.04 mg/kg and 8.25 mg/kg fumonisins, respectively. Fumonisins were enriched by 3.0× for 50 out of 57 hybrid × insect infestation treatment combinations; those seven that differed were Bt maize hybrids were consistently lower in fumonisins than DDGS derived from non-Bt hybrids

Approval Ratings of Inpatient Coercive Interventions in a National Sample of Mental Health Service Users and Staff in England

Objective: To ascertain the degree of approval amongst service users and staff for various coercive measures commonly used in acute mental health care. Methods: A cross-sectional design was adopted. The Attitudes to Containment Measures Questionnaire (ACMQ) was completed by 1,361 service users and 1,226 staff in acute care mental health services from three regions of England. This provided evaluation of eleven coercive measures (e.g. seclusion) on six dimensions of approval (e.g. indignity, safety) in a large national sample. Comparisons between groups were tested using independent samples t-tests, χ2 or Spearman correlations. Results: Both service users and staff disapproved strongly of mechanical restraint and expressed a relative preference for compulsory intramuscular medication and seclusion. Male staff, older service users and staff who had been involved in implementing coercion expressed greater approval of coercive measures. Conclusion: Mechanical restraint remains highly objectionable to staff and service users in English mental health services despite its widespread acceptance elsewhere in the world

Morale is high in acute inpatient psychiatry

Background: Morale on acute psychiatric wards has been considered to be problematic, and is reported to contribute to low quality patient care. Aim: To assess the relationship of staff morale to patient, service environment, physical environment, patient routines, conflict, containment, staff demographics, and staff group variables. Method: A multivariate cross sectional study was undertaken collecting data on morale and other variables on 136 acute admission psychiatric wards in England. Results: Morale was higher than published comparison samples. Length of time in post was correlated with low morale, and qualified nurses had higher emotional exhaustion but also higher personal accomplishment. The level of verbal abuse on a ward was associated with low morale, as was a higher level of social deprivation among patients. Higher levels of order and organisation correlated with better morale. Conclusions: Clear policies relating to the management of verbal abuse by patients, high levels of order and organisation, and staff rotation and education, may all support high morale. Acute inpatient psychiatry is generally a happy and rewarding work environment, and identified problems are likely to be due to other factors

Coherent control of enrichment and conversion of molecular spin isomers

A theoretical model of nuclear spin conversion in molecules controlled by an external electromagnetic radiation resonant to rotational transition has been developed. It has been shown that one can produce an enrichment of spin isomers and influence their conversion rates in two ways, through coherences and through level population change induced by radiation. Influence of conversion is ranged from significant speed up to almost complete inhibition of the process by proper choice of frequency and intensity of the external field.Comment: REVTEX, 13 pages + 6 eps figure

The Bolocam Galactic Plane Survey. XII. Distance Catalog Expansion Using Kinematic Isolation of Dense Molecular Cloud Structures With 13CO(1-0)

We present an expanded distance catalog for 1,710 molecular cloud structures identified in the Bolocam Galactic Plane Survey (BGPS) version 2, representing a nearly threefold increase over the previous BGPS distance catalog. We additionally present a new method for incorporating extant data sets into our Bayesian distance probability density function (DPDF) methodology. To augment the dense-gas tracers (e.g., HCO+(3-2), NH3(1,1)) used to derive line-of-sight velocities for kinematic distances, we utilize the Galactic Ring Survey 13CO(1-0) data to morphologically extract velocities for BGPS sources. The outline of a BGPS source is used to select a region of the GRS 13CO data, along with a reference region to subtract enveloping diffuse emission, to produce a line profile of 13CO matched to the BGPS source. For objects with a HCO+(3-2) velocity, \approx 95% of the new 13CO(1-0) velocities agree with that of the dense gas. A new prior DPDF for kinematic distance ambiguity (KDA) resolution, based on a validated formalism for associating molecular cloud structures with known objects from the literature, is presented. We demonstrate this prior using catalogs of masers with trigonometric parallaxes and HII regions with robust KDA resolutions. The distance catalog presented here contains well-constrained distance estimates for 20% of BGPS V2 sources, with typical distance uncertainties \lesssim 0.5 kpc. Approximately 75% of the well-constrained sources lie within 6 kpc of the Sun, concentrated in the Scutum-Centarus arm. Galactocentric positions of objects additionally trace out portions of the Sagittarius, Perseus, and Outer arms in the first and second Galactic quadrants, and we also find evidence for significant regions of interarm dense gas.Comment: 28 pages, 19 figures. Accepted for publication in ApJ. Distance-Omnibus code available at https://github.com/BGPS/distance-omnibu

Quality of intervention delivery in a cluster randomised controlled trial : a qualitative observational study with lessons for implementation fidelity

Abstract Background Understanding intervention fidelity is an essential part of the evaluation of complex interventions because fidelity not only affects the validity of trial findings, but also because studies of fidelity can be used to identify barriers and facilitators to successful implementation, and so provide important information about factors likely to impact the uptake of the intervention into clinical practice. Participant observation methods have been identified as being particularly valuable in studies of fidelity, yet are rarely used. This study aimed to use these methods to explore the quality of implementation of a complex intervention (Safewards) on mental health wards during a cluster randomised controlled trial. Specific aims were firstly to describe the different ways in which the intervention was implemented, and secondly to explore the contextual factors moderating the quality of intervention delivery, in order to inform ‘real world’ implementation of the intervention. Methods Safewards was implemented on 16 mental health wards in England. We used Research Assistants (RAs) trained in participant observation to record qualitative observational data on the quality of intervention delivery (n = 565 observations). At the end of the trial, two focus groups were conducted with RAs, which were used to develop the coding framework. Data were analysed using thematic analysis. Results There was substantial variation in intervention delivery between wards. We observed modifications to the intervention which were both fidelity consistent and inconsistent, and could enhance or dilute the intervention effects. We used these data to develop a typology which describes the different ways in which the intervention was delivered. This typology could be used as a tool to collect qualitative observational data about fidelity during trials. Moderators of Safewards implementation included systemic, interpersonal, and individual factors and patient responses to the intervention. Conclusions Our study demonstrates how, with appropriate training in participant observation, RAs can collect high-quality observational data about the quality of intervention delivery during a trial, giving a more complete picture of ‘fidelity’ than measurements of adherence alone. Trial registration ISRCTN registry; IRSCTN38001825 . Registered 29 August 201

Cultures of psychiatry and the professional socialization process: the case of containment methods for disturbed patients

Acute mental disorder necessitating admission to hospital is often accompanied by disturbed behaviour that threatens the health of the person concerned or that of those around them. A range of containment methods are used by psychiatric professionals to keep patients and staff safe. These strategies are strongly emotive and attract strong moral valuations, yet differ sharply between countries. This paper reports a study to investigate the relationship between attitudes to these containment methods, and exposure to psychiatric education and practice. It was hypothesized that the culture of psychiatry in the study country would socialise students' views towards the locally dominant pattern of relative evaluations. Nine cohorts of student psychiatric nurses at different stages of their training at one UK University were asked to complete ratings on 11 containment methods. Containment methods fell into five groups, with mechanical restraint and net beds attracting the most severe disapproval. Neither the relative evaluation of methods, nor the intensity of those evaluations, changed systematically with duration of training. The findings support the interpretation that the relative evaluations of psychiatric containment methods are a property of wider national cultures, rather than an isolated tradition of professional psychiatric practice