29,478 research outputs found
A disposable continuum endoscope using piston-driven parallel bellow actuator
This paper presents a novel low cost disposable continuum endoscope based on a piston-driven parallel bellow actuator design. The parallel bellow actuator achieves motion by being pressurized via displacement-controlled pistons. The displacements are generated by rack-and-pinion mechanisms using inexpensive stepper motors. The design concept provides a potential alternative solution to upper gastrointestinal (UGI) diagnosis. The modularity and the use of inexpensive components allow for low fabrication costs and disposability. The use of robotic assistance could facilitate the development of an easier interface for the gastroenterologists, avoiding the nonintuitive manipulation mapping of the traditional UGI endoscopes. We adapt existing kinematic solutions of multi-backbone continuum robots to model continuum parallel bellow actuators. An actuation compensation strategy is presented and validated to address the pneumatic compressibility through the transmission lines. The design concept was prototyped and tested with a custom control platform. The experimental validation shows that the actuation compensation was demonstrated to significantly improve orientation control of the endoscope end-effector. This paper shows the feasibility of the proposed design and lays the foundation toward clinical scenarios
A simple abstraction of arrays and maps by program translation
We present an approach for the static analysis of programs handling arrays,
with a Galois connection between the semantics of the array program and
semantics of purely scalar operations. The simplest way to implement it is by
automatic, syntactic transformation of the array program into a scalar program
followed analysis of the scalar program with any static analysis technique
(abstract interpretation, acceleration, predicate abstraction,.. .). The
scalars invariants thus obtained are translated back onto the original program
as universally quantified array invariants. We illustrate our approach on a
variety of examples, leading to the " Dutch flag " algorithm
Abacavir: its use and hypersensitivity
Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a lifethreatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes, especially HLA-B*5701
Predicting relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis: A Systematic review and meta-analysis
Objectives: Relapses affect 30-50% of patients with ANCA-associated vasculitis (AAV) over 5 years, necessitating long-term treatment. Although there have been studies looking at predictors of relapse in AAV, this research has yet to translate clinically into guidance on tailored therapy. The aim of this systematic review was to identify and meta-analyse existing risk factors from the literature and produce a model to calculate individualised patient risk of relapse. Method: A search strategy was developed to include all studies identifying predictors of AAV relapse using multivariate analysis. Individual risk factors were extracted and pooled hazard ratios (HRs) calculated. A model to predict the time to first relapse based on identified risk factors was tested retrospectively using a cohort of patients with AAV. Results: The review of 2674 abstracts identified 117 papers for full text review, with 16 eligible for inclusion. Pooled HRs were calculated from significant risk factors, including anti-PR3 ANCA positivity [HR 1.69 (95% CI 1.46, 1.94)], cardiovascular involvement [HR 1.78 (95% CI 1.26, 2.53)], creatinine >200 Îźmol/l (relative to creatinine â¤100) [HR 0.39 (95% CI 0.22, 0.69)] and creatinine 101-200 Îźmol/l [HR 0.81 (95% CI 0.77, 0.85)]. Using data from 182 AAV patients to validate the model gave a C-statistic of 0.61. Conclusion: Anti-PR3 ANCA positivity, lower serum creatinine and cardiovascular system involvement are all associated with an increased risk of relapse, and a combination of these risk factors can be used to predict the individualised risk of relapse. In order to produce a clinically useful model to stratify risk, we need to identify more risk factors, with a focus on robust biomarkers
Critical exponents of a multicomponent anisotropic t-J model in one dimension
A recently presented anisotropic generalization of the multicomponent
supersymmetric model in one dimension is investigated. This model of
fermions with general spin- is solved by Bethe ansatz for the ground state
and the low-lying excitations. Due to the anisotropy of the interaction the
model possesses massive modes and one single gapless excitation. The
physical properties indicate the existence of Cooper-type multiplets of
fermions with finite binding energy. The critical behaviour is described by a
conformal field theory with continuously varying exponents depending on
the particle density. There are two distinct regimes of the phase diagram with
dominating density-density and multiplet-multiplet correlations, respectively.
The effective mass of the charge carriers is calculated. In comparison to the
limit of isotropic interactions the mass is strongly enhanced in general.Comment: 10 pages, 3 Postscript figures appended as uuencoded compressed
tar-file to appear in Z. Phys. B, preprint Cologne-94-474
Sommerfeld Enhancement from Multiple Mediators
We study the Sommerfeld enhancement experienced by a scattering object that
couples to a tower of mediators. This can occur in, e.g., models of secluded
dark matter when the mediator scale is generated naturally by hidden-sector
confinement. Specializing to the case of a confining CFT, we show that
off-resonant values of the enhancement can be increased by ~ 20% for cases of
interest when (i) the (strongly-coupled) CFT admits a weakly-coupled dual
description and (ii) the conformal symmetry holds up to the Planck scale.
Larger enhancements are possible for lower UV scales due to an increase in the
coupling strength of the tower.Comment: 17p, 2 figures; v2 JHEP version (inconsequential typo fixed,
references added
Synaptic Cleft Segmentation in Non-Isotropic Volume Electron Microscopy of the Complete Drosophila Brain
Neural circuit reconstruction at single synapse resolution is increasingly
recognized as crucially important to decipher the function of biological
nervous systems. Volume electron microscopy in serial transmission or scanning
mode has been demonstrated to provide the necessary resolution to segment or
trace all neurites and to annotate all synaptic connections.
Automatic annotation of synaptic connections has been done successfully in
near isotropic electron microscopy of vertebrate model organisms. Results on
non-isotropic data in insect models, however, are not yet on par with human
annotation.
We designed a new 3D-U-Net architecture to optimally represent isotropic
fields of view in non-isotropic data. We used regression on a signed distance
transform of manually annotated synaptic clefts of the CREMI challenge dataset
to train this model and observed significant improvement over the state of the
art.
We developed open source software for optimized parallel prediction on very
large volumetric datasets and applied our model to predict synaptic clefts in a
50 tera-voxels dataset of the complete Drosophila brain. Our model generalizes
well to areas far away from where training data was available
Development of hepatic pathology in GBVâBâinfected redâbellied tamarins (Saguinus labiatus)
GB virus B (GBVâB) is a new world monkeyâassociated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of antiviral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterized changes in tamarins. As early as 2 weeks postâinfection histological changes were noticeable, and these were established in all animals by 6 weeks. Despite high levels of liverâassociated viral RNA, there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBVâB infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology
Electroweak Constraints on Warped Geometry in Five Dimensions and Beyond
Here we consider the tree level corrections to electroweak (EW) observables
from standard model (SM) particles propagating in generic warped extra
dimensions. The scale of these corrections is found to be dominated by three
parameters, the Kaluza-Klein (KK) mass scale, the relative coupling of the KK
gauge fields to the Higgs and the relative coupling of the KK gauge fields to
fermion zero modes. It is found that 5D spaces that resolve the hierarchy
problem through warping typically have large gauge-Higgs coupling. It is also
found in where the additional dimensions are warped the relative
gauge-Higgs coupling scales as a function of the warp factor. If the warp
factor of the additional spaces is contracting towards the IR brane, both the
relative gauge-Higgs coupling and resulting EW corrections will be large.
Conversely EW constraints could be reduced by finding a space where the
additional dimension's warp factor is increasing towards the IR brane. We
demonstrate that the Klebanov Strassler solution belongs to the former of these
possibilities.Comment: 18 pages, 3 figures (references added) version to appear in JHE
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