Particle interactions and lattice dynamics: Scenarios for efficient bidirectional stochastic transport?

Intracellular transport processes driven by molecular motors can be described by stochastic lattice models of self-driven particles. Here we focus on bidirectional transport models excluding the exchange of particles on the same track. We explore the possibility to have efficient transport in these systems. One possibility would be to have appropriate interactions between the various motors' species, so as to form lanes. However, we show that the lane formation mechanism based on modified attachment/detachment rates as it was proposed previously is not necessarily connected to an efficient transport state and is suppressed when the diffusivity of unbound particles is finite. We propose another interaction mechanism based on obstacle avoidance that allows to have lane formation for limited diffusion. Besides, we had shown in a separate paper that the dynamics of the lattice itself could be a key ingredient for the efficiency of bidirectional transport. Here we show that lattice dynamics and interactions can both contribute in a cooperative way to the efficiency of transport. In particular, lattice dynamics can decrease the interaction threshold beyond which lanes form. Lattice dynamics may also enhance the transport capacity of the system even when lane formation is suppressed.Comment: 25 pages, 17 figures, 2 table

Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants

Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was to investigate the interactions of contaminants with scalp hair and underlying skin using a hybrid in vitro diffusion cell model. The in vitro hybrid test system comprised “curtains” of human hair mounted onto sections of excised porcine skin within a modified diffusion cell. The results demonstrated that hair substantially reduced underlying scalp skin contamination and that hair may provide a limited decontamination effect by removing contaminants from the skin surface. This hybrid test system may have application in the development of improved chemical incident response processes through the evaluation of various hair and skin decontamination strategies.Peer reviewedFinal Published versio

Antibunched photons emitted by a dc-biased Josephson junction

We show experimentally that a dc biased Josephson junction in series with a high-enough-impedance microwave resonator emits antibunched photons. Our resonator is made of a simple microfabricated spiral coil that resonates at 4.4 GHz and reaches a 1.97kΩ characteristic impedance. The second order correlation function of the power leaking out of the resonator drops down to 0.3 at zero delay, which demonstrates the antibunching of the photons emitted by the circuit at a rate of 6×10^7 photons per second. Results are found in quantitative agreement with our theoretical predictions. This simple scheme could offer an efficient and bright single-photon source in the microwave domain

Frozen shuffle update for an asymmetric exclusion process on a ring

We introduce a new rule of motion for a totally asymmetric exclusion process (TASEP) representing pedestrian traffic on a lattice. Its characteristic feature is that the positions of the pedestrians, modeled as hard-core particles, are updated in a fixed predefined order, determined by a phase attached to each of them. We investigate this model analytically and by Monte Carlo simulation on a one-dimensional lattice with periodic boundary conditions. At a critical value of the particle density a transition occurs from a phase with `free flow' to one with `jammed flow'. We are able to analytically predict the current-density diagram for the infinite system and to find the scaling function that describes the finite size rounding at the transition point.Comment: 16 page

On the decay of turbulence in plane Couette flow

The decay of turbulent and laminar oblique bands in the lower transitional range of plane Couette flow is studied by means of direct numerical simulations of the Navier--Stokes equations. We consider systems that are extended enough for several bands to exist, thanks to mild wall-normal under-resolution considered as a consistent and well-validated modelling strategy. We point out a two-stage process involving the rupture of a band followed by a slow regression of the fragments left. Previous approaches to turbulence decay in wall-bounded flows making use of the chaotic transient paradigm are reinterpreted within a spatiotemporal perspective in terms of large deviations of an underlying stochastic process.Comment: ETC13 Conference Proceedings, 6 pages, 5 figure

Illumination devices for photodynamic therapy of the oral cavity

Three compact and efficient designs are proposed to deliver an average irradiance of 50 mW/cm2 with spatial uniformity well above 90% over a 25 mm2 target area for photodynamic therapy of the oral cavity. The main goal is to produce uniform illumination on the target while limiting irradiation of healthy tissue, thus overcoming the need of shielding the whole oral cavity and greatly simplifying the treatment protocol. The first design proposed consists of a cylindrical diffusing fiber placed in a tailored reflector derived from the edge-ray theorem with dimensions 5.5 × 7.2 × 10 mm3; the second device combines a fiber illuminator and a lightpipe with dimensions 6.8 × 6.8 × 50 mm3; the third design, inspired by the tailored reflector, is based on a cylindrical diffusing fiber and a cylinder reflector with dimensions 5 × 10 × 11 mm3. A prototype for the cylinder reflector was built that provided the required illumination for photodynamic therapy of the oral cavity, producing a spatial uniformity on the target above 94% and an average irradiance of 51 mW/cm2 for an input power of 70 mW

Accurate calibration of test mass displacement in the LIGO interferometers

We describe three fundamentally different methods we have applied to calibrate the test mass displacement actuators to search for systematic errors in the calibration of the LIGO gravitational-wave detectors. The actuation frequencies tested range from 90 Hz to 1 kHz and the actuation amplitudes range from 1e-6 m to 1e-18 m. For each of the four test mass actuators measured, the weighted mean coefficient over all frequencies for each technique deviates from the average actuation coefficient for all three techniques by less than 4%. This result indicates that systematic errors in the calibration of the responses of the LIGO detectors to differential length variations are within the stated uncertainties.Comment: 10 pages, 6 figures, submitted on 31 October 2009 to Classical and Quantum Gravity for the proceedings of 8th Edoardo Amaldi Conference on Gravitational Wave

Texture-Modified Diet for Improving the Management of Oropharyngeal Dysphagia in Nursing Home Residents: An Expert Review.

Abstract Objectives This paper provides evidence-based and, when appropriate, expert reviewed recommendations for long-stay residents who are prescribed texture-modified diets (TMDs), with the consideration that these residents are at high risk of worsening oropharyngeal dysphagia (OD), malnutrition, dehydration, aspiration pneumonia, and OD-associated mortality, poorer quality of life and high costs. Design Nestlé Health Science funded an initial virtual meeting attended by all authors, in which the unmet needs and subsequent recommendations for OD management were discussed. The opinions, results, and recommendations detailed in this paper are those of the authors, and are independent of funding sources. Setting OD is common in nursing home (NH) residents, and is defined as the inability to initiate and perform safe swallowing. The long-stay NH resident population has specific characteristics marked by a shorter life expectancy relative to community-dwelling older adults, high prevalence of multimorbidity with a high rate of complications, dementia, frailty, disability, and often polypharmacy. As a result, OD is associated with malnutrition, dehydration, aspiration pneumonia, functional decline, and death. Complications of OD can potentially be prevented with the use of TMDs. Results This report presents expert opinion and evidence-informed recommendations for best practice on the nutritional management of OD. It aims to highlight the practice gaps between the evidence-based management of OD and real-world patterns, including inadequate dietary provision and insufficient staff training. In addition, the unmet need for OD screening and improvements in therapeutic diets are explored and discussed. Conclusion There is currently limited empirical evidence to guide practice in OD management. Given the complex and heterogeneous population of long-stay NH residents, some 'best practice' approaches and interventions require extensive efficacy testing before further changes in policy can be implemented

Modelling of the Total Electronic Content and magnetic field anomalies generated by the 2011 Tohoku-oki tsunami and associated acoustic-gravity waves,

International audienceIn this work, numerical simulations of the atmospheric and ionospheric anomalies are performed for the Tohoku-Oki tsunami (2011 March 11). The Tsunami-Atmosphere-Ionosphere (TAI) coupling mechanism via acoustic gravity waves (AGWs) is explored theoretically using the TAI-coupled model. For the modelled tsunami wave as an input, the coupled model simulates the wind, density and temperature disturbances or anomalies in the atmosphere and electron density/magnetic anomalies in the F region of the ionosphere. Also presented are the GPS-total electron content (TEC) and ground-based magnetometer measurements during the first hour of tsunami and good agreements are found between modelled and observed anomalies. At first, within 6 min from the tsunami origin, the simulated wind anomaly at 250 km altitude and TEC anomaly appear as the dipole-shaped disturbances around the epicentre, then as the concentric circular wave fronts radially moving away from the epicentre with the horizontal velocity ∼800 m s−1 after 12 min followed by the slow moving (horizontal velocity ∼250 m s−1) wave disturbance after 30 min. The detailed vertical-horizontal propagation characteristics suggest that the anomalies appear before and after 30 min are associated with the acoustic and gravity waves, respectively. Similar propagation characteristics are found from the GPS-TEC and magnetic measurements presented here and also reported from recent studies. The modelled magnetic anomaly in the F region ionosphere is found to have similar temporal variations with respect to the epicentre distance as that of the magnetic anomaly registered from the ground-based magnetometers. The high-frequency component ∼10 min of the simulated wind, TEC and magnetic anomalies in the F region develops within 6-7 min after the initiation of the tsunami, suggesting the importance of monitoring the high-frequency atmospheric/ionospheric anomalies for the early warning. These anomalies are found to maximize across the epicentre in the direction opposite to the tsunami propagation suggesting that the large atmospheric/ionospheric disturbances are excited in the region where tsunami does not travel

Thermodynamic formalism for systems with Markov dynamics

The thermodynamic formalism allows one to access the chaotic properties of equilibrium and out-of-equilibrium systems, by deriving those from a dynamical partition function. The definition that has been given for this partition function within the framework of discrete time Markov chains was not suitable for continuous time Markov dynamics. Here we propose another interpretation of the definition that allows us to apply the thermodynamic formalism to continuous time. We also generalize the formalism --a dynamical Gibbs ensemble construction-- to a whole family of observables and their associated large deviation functions. This allows us to make the connection between the thermodynamic formalism and the observable involved in the much-studied fluctuation theorem. We illustrate our approach on various physical systems: random walks, exclusion processes, an Ising model and the contact process. In the latter cases, we identify a signature of the occurrence of dynamical phase transitions. We show that this signature can already be unravelled using the simplest dynamical ensemble one could define, based on the number of configuration changes a system has undergone over an asymptotically large time window.Comment: 64 pages, LaTeX; version accepted for publication in Journal of Statistical Physic