1,671 research outputs found
Autonomic dysfunction in progressive supranuclear palsy
Background: The degree of involvement of the autonomic nervous system in progressive supranuclear palsy (PSP) has been investigated in several studies, often providing conflicting results. There is a need for a better characterization of autonomic dysfunction in PSP, to enhance our understanding of this highly disabling neurodegenerative disease including patients’ needs and possibly be of value for clinicians in the differential diagnosis among Parkinsonian syndromes. Methods: We applied a systematic methodology to review existing literature on Pubmed regarding autonomic nervous system involvement in PSP. Results: PSP reported quite frequently symptoms suggestive of autonomic dysfunction in all domains. Cardiovascular autonomic testing showed in some cases a certain degree of impairment (never severe). There was some evidence suggesting bladder dysfunction particularly in the storage phase. Dysphagia and constipation were the most common gastrointestinal symptoms. Instrumental tests seemed to confirm sudomotor and pupillomotor disturbances. Conclusions: PSP patients frequently reported visceral symptoms, however objective testing showed that not always these reflected actual autonomic impairment. Further studies are needed to better delineate autonomic profile and its prognostic role in PSP
Dynamic validation of the Planck/LFI thermal model
The Low Frequency Instrument (LFI) is an array of cryogenically cooled
radiometers on board the Planck satellite, designed to measure the temperature
and polarization anisotropies of the cosmic microwave backgrond (CMB) at 30, 44
and 70 GHz. The thermal requirements of the LFI, and in particular the
stringent limits to acceptable thermal fluctuations in the 20 K focal plane,
are a critical element to achieve the instrument scientific performance.
Thermal tests were carried out as part of the on-ground calibration campaign at
various stages of instrument integration. In this paper we describe the results
and analysis of the tests on the LFI flight model (FM) performed at Thales
Laboratories in Milan (Italy) during 2006, with the purpose of experimentally
sampling the thermal transfer functions and consequently validating the
numerical thermal model describing the dynamic response of the LFI focal plane.
This model has been used extensively to assess the ability of LFI to achieve
its scientific goals: its validation is therefore extremely important in the
context of the Planck mission. Our analysis shows that the measured thermal
properties of the instrument show a thermal damping level better than
predicted, therefore further reducing the expected systematic effect induced in
the LFI maps. We then propose an explanation of the increased damping in terms
of non-ideal thermal contacts.Comment: Planck LFI technical papers published by JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/1748-022
Thermal susceptibility of the Planck-LFI receivers
This paper is part of the Prelaunch status LFI papers published on JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/jinst .
This paper describes the impact of the Planck Low Frequency Instrument front
end physical temperature fluctuations on the output signal. The origin of
thermal instabilities in the instrument are discussed, and an analytical model
of their propagation and impact on the receivers signal is described. The
experimental test setup dedicated to evaluate these effects during the
instrument ground calibration is reported together with data analysis methods.
Finally, main results obtained are discussed and compared to the requirements.Comment: This is an author-created, un-copyedited version of an article
accepted for publication in Journal of Instrumentation. IOP Publishing Ltd is
not responsible for any errors or omissions in this version of the manuscript
or any version derived from it. The definitive publisher authenticated
version is available online at 10.1088/1748-0221/4/12/T1201
Dictionary Matching with One Gap
The dictionary matching with gaps problem is to preprocess a dictionary
of gapped patterns over alphabet , where each
gapped pattern is a sequence of subpatterns separated by bounded
sequences of don't cares. Then, given a query text of length over
alphabet , the goal is to output all locations in in which a
pattern , , ends. There is a renewed current interest
in the gapped matching problem stemming from cyber security. In this paper we
solve the problem where all patterns in the dictionary have one gap with at
least and at most don't cares, where and are
given parameters. Specifically, we show that the dictionary matching with a
single gap problem can be solved in either time and
space, and query time , where is the number
of patterns found, or preprocessing time and space: , and query
time , where is the number of patterns found.
As far as we know, this is the best solution for this setting of the problem,
where many overlaps may exist in the dictionary.Comment: A preliminary version was published at CPM 201
Imaging the first light: experimental challenges and future perspectives in the observation of the Cosmic Microwave Background Anisotropy
Measurements of the cosmic microwave background (CMB) allow high precision
observation of the Last Scattering Surface at redshift 1100. After the
success of the NASA satellite COBE, that in 1992 provided the first detection
of the CMB anisotropy, results from many ground-based and balloon-borne
experiments have showed a remarkable consistency between different results and
provided quantitative estimates of fundamental cosmological properties. During
2003 the team of the NASA WMAP satellite has released the first improved
full-sky maps of the CMB since COBE, leading to a deeper insight into the
origin and evolution of the Universe. The ESA satellite Planck, scheduled for
launch in 2007, is designed to provide the ultimate measurement of the CMB
temperature anisotropy over the full sky, with an accuracy that will be limited
only by astrophysical foregrounds, and robust detection of polarisation
anisotropy. In this paper we review the experimental challenges in high
precision CMB experiments and discuss the future perspectives opened by second
and third generation space missions like WMAP and Planck.Comment: To be published in "Recent Research Developments in Astronomy &
Astrophysics Astrophysiscs" - Vol I
Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons (MN). Importantly, MN degeneration is intimately linked to oligodendrocyte dysfunction and impaired capacity of oligodendrocyte precursor cells (OPCs) to regenerate the myelin sheath enwrapping and protecting neuronal axons. Thus, improving OPC reparative abilities represents an innovative approach to counteract MN loss. A pivotal regulator of OPC maturation is the P2Y-like G protein-coupled receptor 17 (GPR17), whose role in ALS has never been investigated. In other models of neurodegeneration, an abnormal increase of GPR17 has been invariably associated to myelin defects and its pharmacological manipulation succeeded in restoring endogenous remyelination. Here, we analyzed GPR17 alterations in the SOD1G93A ALS mouse model and assessed in vitro whether this receptor could be targeted to correct oligodendrocyte alterations. Western-blot and immunohistochemical analyses showed that GPR17 protein levels are significantly increased in spinal cord of ALS mice at pre-symptomatic stage; this alteration is exacerbated at late symptomatic phases. Concomitantly, mature oligodendrocytes degenerate and are not successfully replaced. Moreover, OPCs isolated from spinal cord of SOD1G93A mice display defective differentiation compared to control cells, which is rescued by treatment with the GPR17 antagonist montelukast. These data open novel therapeutic perspectives for ALS management
Physical decline and cognitive impairment in frail hypertensive elders during COVID-19
Background: Hypertension is common in older adults and its incidence increases with age. We investigated the correlation between physical and cognitive impairment in older adults with frailty and hypertension. Methods: We recruited frail hypertensive older adults during the COVID-19 pandemic, between March 2021 and December 2021. Global cognitive function was assessed through the Montreal Cognitive Assessment (MoCA), physical frailty assessment was performed following the Fried criteria, and all patients underwent physical evaluation through 5-meter gait speed test. Results: We enrolled 203 frail hypertensive older adults and we found a significant correlation between MoCA score and gait speed test (r: 0.495; p<0.001) in our population. To evaluate the impact of comorbidities and other factors on our results, we applied a linear regression analysis with MoCA score as a dependent variable, observing a significant association with age, diabetes, chronic obstructive pulmonary disease (COPD), and gait speed test. Conclusions: Our study revealed for the first time a significant correlation between physical and cognitive impairment in frail hypertensive elderly subjects
Surfactant-like Effect and Dissolution of Ultrathin Fe Films on Ag(001)
The phase immiscibility and the excellent matching between Ag(001) and
Fe(001) unit cells (mismatch 0.8 %) make Fe/Ag growth attractive in the field
of low dimensionality magnetic systems. Intermixing could be drastically
limited at deposition temperatures as low as 140-150 K. The film structural
evolution induced by post-growth annealing presents many interesting aspects
involving activated atomic exchange processes and affecting magnetic
properties. Previous experiments, of He and low energy ion scattering on films
deposited at 150 K, indicated the formation of a segregated Ag layer upon
annealing at 550 K. Higher temperatures led to the embedding of Fe into the Ag
matrix. In those experiments, information on sub-surface layers was attained by
techniques mainly sensitive to the topmost layer. Here, systematic PED
measurements, providing chemical selectivity and structural information for a
depth of several layers, have been accompanied with a few XRD rod scans,
yielding a better sensitivity to the buried interface and to the film long
range order. The results of this paper allow a comparison with recent models
enlightening the dissolution paths of an ultra thin metal film into a different
metal, when both subsurface migration of the deposit and phase separation
between substrate and deposit are favoured. The occurrence of a surfactant-like
stage, in which a single layer of Ag covers the Fe film is demonstrated for
films of 4-6 ML heated at 500-550 K. Evidence of a stage characterized by the
formation of two Ag capping layers is also reported. As the annealing
temperature was increased beyond 700 K, the surface layers closely resembled
the structure of bare Ag(001) with the residual presence of subsurface Fe
aggregates.Comment: 4 pages, 3 figure
The ARIEL Instrument Control Unit design for the M4 Mission Selection Review of the ESA's Cosmic Vision Program
The Atmospheric Remote-sensing Infrared Exoplanet Large-survey mission
(ARIEL) is one of the three present candidates for the ESA M4 (the fourth
medium mission) launch opportunity. The proposed Payload will perform a large
unbiased spectroscopic survey from space concerning the nature of exoplanets
atmospheres and their interiors to determine the key factors affecting the
formation and evolution of planetary systems. ARIEL will observe a large number
(>500) of warm and hot transiting gas giants, Neptunes and super-Earths around
a wide range of host star types, targeting planets hotter than 600 K to take
advantage of their well-mixed atmospheres. It will exploit primary and
secondary transits spectroscopy in the 1.2-8 um spectral range and broad-band
photometry in the optical and Near IR (NIR). The main instrument of the ARIEL
Payload is the IR Spectrometer (AIRS) providing low-resolution spectroscopy in
two IR channels: Channel 0 (CH0) for the 1.95-3.90 um band and Channel 1 (CH1)
for the 3.90-7.80 um range. It is located at the intermediate focal plane of
the telescope and common optical system and it hosts two IR sensors and two
cold front-end electronics (CFEE) for detectors readout, a well defined process
calibrated for the selected target brightness and driven by the Payload's
Instrument Control Unit (ICU).Comment: Experimental Astronomy, Special Issue on ARIEL, (2017
Planck-LFI: Design and Performance of the 4 Kelvin Reference Load Unit
The LFI radiometers use a pseudo-correlation design where the signal from the
sky is continuously compared with a stable reference signal, provided by a
cryogenic reference load system. The reference unit is composed by small
pyramidal horns, one for each radiometer, 22 in total, facing small absorbing
targets, made of a commercial resin ECCOSORB CR (TM), cooled to approximately
4.5 K. Horns and targets are separated by a small gap to allow thermal
decoupling. Target and horn design is optimized for each of the LFI bands,
centered at 70, 44 and 30 GHz. Pyramidal horns are either machined inside the
radiometer 20K module or connected via external electro-formed bended
waveguides. The requirement of high stability of the reference signal imposed a
careful design for the radiometric and thermal properties of the loads.
Materials used for the manufacturing have been characterized for thermal, RF
and mechanical properties. We describe in this paper the design and the
performance of the reference system.Comment: This is an author-created, un-copyedited version of an article
accepted for publication in JINST. IOP Publishing Ltd is not responsible for
any errors or omissions in this version of the manuscript or any version
derived from it. The definitive publisher authenticated version is available
online at [10.1088/1748-0221/4/12/T12006]. 14 pages, 34 figure
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