A sentiment analysis software framework for the support of business information architecture in the tourist sector

In recent years, the increased use of digital tools within the Peruvian tourism industry has created a corresponding increase in revenues. However, both factors have caused increased competition in the sector that in turn puts pressure on small and medium enterprises' (SME) revenues and profitability. This study aims to apply neural network based sentiment analysis on social networks to generate a new information search channel that provides a global understanding of user trends and preferences in the tourism sector. A working data-analysis framework will be developed and integrated with tools from the cloud to allow a visual assessment of high probability outcomes based on historical data, to help SMEs estimate the number of tourists arriving and places they want to visit, so that they can generate desirable travel packages in advance, reduce logistics costs, increase sales, and ultimately improve both quality and precision of customer service

Structural and luminescence imaging and characterisation of semiconductors in the scanning electron microscope

The scanning electron microscopy techniques of electron backscatter diffraction (EBSD), electron channelling contrast imaging (ECCI) and hyperspectral cathodoluminescence imaging (CL) provide complementary information on the structural and luminescence properties of materials rapidly and non-destructively, with a spatial resolution of tens of nanometres. EBSD provides crystal orientation, crystal phase and strain analysis, whilst ECCI is used to determine the planar distribution of extended defects over a large area of a given sample. CL reveals the influence of crystal structure, composition and strain on intrinsic luminescence and/or reveals defect-related luminescence. Dark features are also observed in CL images where carrier recombination at defects is non-radiative. The combination of these techniques is a powerful approach to clarifying the role of crystallography and extended defects on a materials' light emission properties. Here we describe the EBSD, ECCI and CL techniques and illustrate their use for investigating the structural and light emitting properties of UV-emitting nitride semiconductor structures. We discuss our investigations of the type, density and distribution of defects in GaN, AlN and AlGaN thin films and also discuss the determination of the polarity of GaN nanowires

Sophora interruptaBedd. root-derived flavonoids as prominent antiviral agents against Newcastle disease virus

The discovery and development of novel antiviral drugs from natural sources is continuously increasing due to limitations of currently available drugs such as toxic side effects, drug residue risk factors, high costs, and poor therapeutic strategies. Also, there are very few known antiviral drugs that are effective against only specific viruses. Hence, the present study is intended to isolate and characterize potent antiviral compounds from the methanolic root extract ofSophora interruptaBedd. against avian paramyxovirus, Newcastle disease virus (NDV) and to distinguish the molecular basis of antiviral compounds. The two isolated flavonoids, maackiain (SR-1) and echinoisoflavanone (SR-2) exhibited the best antiviral activities against NDV infection in chicken embryo fibroblast cell lines compared to the standard antiviral drug, Ribavirin. Further, thein vitrostudies and quantitative PCR analysis suggests that these flavonoids inhibit the viral entry, replication, and transcription, which may be beneficial as a promising strategy for the treatment of viral infections. Besides, the molecular docking studies ofSR-1andSR-2exhibited high binding affinities of −7.6 and −8.0 kcal mol−1, respectively, and marked interactions with the NDV surface glycoprotein, hemagglutinin neuraminidase (HN). Also, thein silicotoxicity properties as well pharmacokinetic studies of isolates revealed them as pharmacologically potent antiviral compounds. © The Royal Society of Chemistry 2020.Council of Scientific and Industrial Research, India, CSIRThe author WR thanks the Council of Scientic and Industrial Research (CSIR), New Delhi and the authors CB, AR, and PR are grateful to UGC-BSR, New Delhi for nancial assistance under CSIR-MRP and UGC-RFSMS (BSR) programs. Furthermore, all the authors are thankful to National Institute of Animal Biotechnology (NIAB), Hyderabad for providing laboratory facilities to carry out the viral studies

Early metabolic inhibition-induced intracellular sodium and calcium increase in rat cerebellar granule cells

Possible mechanisms responsible for the increases in intracellular calcium ([Ca2+]i) and sodium ([Na+]i) levels seen during metabolic inhibition were investigated by continuous [Ca2+]i and [Na+]i measurement in cultured rat cerebellar granule cells. An initial small mitochondrial Ca2+ release was seen, followed by a large influx of extracellular Ca2+. A large influx of extracellular Na+ was also seen.The large [Ca2+]i increase was not due to opening of voltage-dependent or voltage-independent calcium channels, activation of NMDA/non-NMDA channels, activation of the Nai+-Cao2+ exchanger, or inability of plasmalemmal Ca2+-ATPase to extrude, or mitochondria to take up, calcium.The large [Na+]i increase was not due to activation of the TTX-sensitive Na+ channel, the Nai+-Cao2+ exchanger, the Na+-H+ exchanger, or the Na+−K+-2Cl− cotransporter, or an inability of Na+−K+-ATPase to extrude the intracellular sodium.Phospholipase A2 (PLA2) activation may be involved in the large influx, since both were completely inhibited by PLA2 inhibitors. Moreover, melittin (a PLA2 activator) or lysophosphatidylcholine or arachidonic acid (both PLA2 activation products) caused similar responses. Inhibition of PLA2 activity may help prevent the influx of these ions that may result in serious brain injury and oedema during hypoxia/ischaemia