816 research outputs found
Treponema denticola in Disseminating Endodontic Infections
Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial âred-complexâ organisms (RC) (Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-type (WT) and severe-combined-immunodeficiency (SCID) mice was analyzed. After 21 days, a high incidence (5/10) of orofacial abscesses was observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice infected with the red-complex organisms or in wildtype mice. Splenomegaly was present in all groups, but only mono-infected SCID mice had weight loss. T. denticola DNA was detected in the spleen, heart, and brain of mono-infected SCID mice and in the spleen from mono-infected wild-type mice, which also had more periapical bone resorption. The results indicate that T. denticola has high pathogenicity, including dissemination to distant organs, further substantiating its potential importance in oral and linked systemic conditions
Pulpotomy for treatment of complicated crown fractures in permanent teeth: A systematic review
BACKGROUND: Consensus on the treatment of choice for complicated crown fractures of teeth is limited. Recent guidance recommends vitalâpulpâtherapy; however, the preferred type is not specified. Higher success rates for pulpotomy compared to pulpâcapping have been documented, which suggests pulpotomy may be a preferable option for complicated crownâfractures. OBJECTIVES: The purpose of this systematic review was to determine the success rate of pulpotomy (partial and complete) on teeth that suffered complicated crown fractures. Participants: patients who have suffered a complicated crown fracture to an anterior permanent tooth. Intervention: pulpotomy (partial or complete). Comparator: pulpâcapping or root canal treatment. Outcome: combined clinical and radiographic success at or after 12Â months. METHODS: A systematic literature using key search terms was conducted using PubMed, Web of Science and CochraneâCentralâRegisterâofâControlledâTrials (CENTRAL) as well as a grey literature search from inception to May 2021 and without language restricted to English. Strict inclusion criteria were applied. A standardized tool with defined criteria to assess the risk of bias in each study was used. For nonârandomized comparative trials, the RobinsâI tool was used while the NewcastleâOttawa scale was used for nonâcomparative nonârandomized studies. RESULTS: Seven retrospective clinical studies were included. The studies reported high success rates for pulpotomy with overall success ranges for partial or complete pulpotomy ranging from 75% to 96%. One study compared the success rates of pulpotomy to an alternative treatment option pulp capping (90.9% vs. 67%, respectively). Due to the lack of homogeneity in the included studies, a metaâanalysis was not possible. DISCUSSION: This review highlights the limited evidence based for the current guidance on treatment of complicated crown fractures. The findings of the review indicate high success rates for pulpotomy; however, there is a moderate risk of bias and small sample sizes in the included studies with the result that the overall results should be interpreted with caution. CONCLUSION: Within the limitations of this review, the benefits and high success rates reported for partial pulpotomy suggest this procedure, rather than pulpâcapping, should be considered as the treatment of choice for both immature and mature teeth that have suffered complicated crownâfractures
Investigation of Lactation Period and Technological Treatments on Mineral Composition and IR-Profiles of Donkey Milk by Chemometrics
Featured Application: Multi-platform analysis of donkey milk. Donkey milk represents an efficient substitute for human milk in infantsâ diets being unlikely to cause allergic reactions. In this study, different donkey milks were collected at two lactation times (T0 and T1), subjected to freezingâthawing and freeze-drying, and analyzed by Inductively Coupled PlasmaâOptical Emission Spectroscopy (ICP-OES) and ATR-FT-IR. The data collected on freezeâthaw (FT-) and reconstituted (R-)milks were investigated by ANOVAâSimultaneous Component Analysis (ASCA) and Principal Component Analysis (PCA). The following concentrations (ÎŒg/mL) for FT and R-milks, respectively, at T0, were found: Ca: 712 ± 71, 600 ± 72; Fe: 0.7 ± 0.3, 0.1 ± 0.1; K: 595 ± 49, 551 ± 59; Mg: 75 ± 5, 67 ± 4; Na: 117 ± 16, 114 ± 16; P: 403 ± 30, 404 ± 38; Zn: 1.6 ± 0.2, 1.6 ± 0.3. At T1, the concentrations (ÎŒg/mL for FT and R-milks, respectively) were: Ca: 692 ± 60, 583 ± 43; Fe: 0.13 ± 0.02, 0.13 ± 0.03; K: 641 ± 71, 574 ± 61; Mg: 72 ± 4, 63 ± 1; Na: 116 ± 9, 109 ± 8; P: 412 ± 30, 405 ± 24; Zn: 1.6 ± 0.3, 1.6 ± 0.3. ASCA demonstrated the treatment has a substantial effect, and PCA revealed that the largest quantities of metals, specifically Fe, Mg, and Ca for T0 and K, P, and Na for T1, are present in the FT-milk samples. The IR spectra of FT- and R-milks revealed no macroscopic changes among them or between lactation periods, indicating this technique may not suitably capture variability in lactation or conservation processes in donkey milk. Despite the relatively small sample size, this study offers insight on the mineral composition changes in donkey milk and emphasizes the significance of milk preprocessing and the lactation period on it
Distorted Copulas: Constructions and Tail Dependence
Given a copula C, we examine under which conditions on an order isomorphism Ï of [0, 1] the distortion C Ï: [0, 1]2 â [0, 1], C Ï(x, y) = Ï{C[Ïâ1(x), Ïâ1(y)]} is again a copula. In particular, when the copula C is totally positive of order 2, we give a sufficient condition on Ï that ensures that any distortion of C by means of Ï is again a copula. The presented results allow us to introduce in a more flexible way families of copulas exhibiting different behavior in the tails
Definition of a Core Collection and Construction of a Reference Set for Genome-Wide Association Studies from a Large Prunus persica Germplasm Collection
Genome-wide association studies take advantage of the natural variation present in germplasm repositories for identifying genes underlying agronomic traits, through plant molecular and phenotypic characterization. For tree crops, in vivo maintenance and phenotyping are particularly onerous and the reduction of redundancy and duplicates could help lowering management costs. In the frame of the European project FruitBreedomics, a collection of 1580 Prunus accessions from different institutions in Europe and China has been genotyped with the IPSC 9K SNP Array and phenotyped for different agronomic traits and a GWAS analysis with 4271 SNPs on 7 monogenic traits has been carried out (Micheletti et al. 2015). In the present work, the same set of 4271 SNP markers was used to identify a peach core collection by applying the maximization strategy implemented in the software PowerCore v 1.0 (Kim et al. 2007). Out of a total of 1540 a core of 72 (C72) accessions was identified, representing 4.7% sampling size. C72 contains the accessions with higher diversity representing the total allelic coverage with an efficiency index of 0.83 with respect to random sampling. In the view of setting up a genomic tool for GWAS analyses a reference subset of 150 accessions was also developed taking into account allelic and phenotypic traits representativeness through the maximization strategy, population stratification and controlled redundancy required to have enough statistical power. Preliminary PCA analysis shows population structure to explain less than 30% of variability due to the local varieties. Validation of the reference set will also be presented
A sharp condition for scattering of the radial 3d cubic nonlinear Schroedinger equation
We consider the problem of identifying sharp criteria under which radial
(finite energy) solutions to the focusing 3d cubic nonlinear
Schr\"odinger equation (NLS) scatter,
i.e. approach the solution to a linear Schr\"odinger equation as . The criteria is expressed in terms of the scale-invariant quantities
and , where denotes the
initial data, and and denote the (conserved in time) mass and
energy of the corresponding solution . The focusing NLS possesses a
soliton solution , where is the ground-state solution to a
nonlinear elliptic equation, and we prove that if and
, then the
solution is globally well-posed and scatters. This condition is sharp in
the sense that the soliton solution , for which equality in these
conditions is obtained, is global but does not scatter. We further show that if
, then the solution blows-up in finite time. The
technique employed is parallel to that employed by Kenig-Merle \cite{KM06a} in
their study of the energy-critical NLS
Stable self-similar blow-up dynamics for slightly -supercritical generalized KdV equations
In this paper we consider the slightly -supercritical gKdV equations
, with the nonlinearity
and . We will prove the existence and
stability of a blow-up dynamic with self-similar blow-up rate in the energy
space and give a specific description of the formation of the singularity
near the blow-up time.Comment: 38 page
Acute stroke-like deficits associated with nonketotic hyperglycemic hyperosmolar state: an illustrative case and systematic review of literature
INTRODUCTION: Nonketotic hyperglycemic hyperosmolar state (NKHHS) is associated with a wide spectrum of neurological syndromes including acute stroke-like deficits. Clinical features and etiology have not been established yet. METHODS: Here we provide a case illustration and systematic review on non-epileptic acute neurological deficits in NKHSS. The systematic literature search followed PRISMA guidelines and a predefined protocol, including cases of NKHSS with acute stroke-like presentation. RESULTS: The database search yielded 18 cases. Hemianopia was the most common clinical presentation (73%), followed by partial or total anterior circulation syndrome (26%). Patients with symptoms of acute anterior circulation infarct were significantly older (69.5â±â5.1 vs. 52.2â±â13.9 years; pâ=â0.03) and showed higher mean glucose levels at the admission vs. those with hemianopia (674.8â±â197.2 vs. 529.4â±â190.8 mg/dL; pâ=â0.16). Brain MRI was performed in 89% of patients, resulting abnormal in 71% of them, especially hemianopic (91%). Subcortical hypointensities in T2-FLAIR MR sequences were present in all the analyzed cases. Cortical DWI hyperintensities were also common (64%). EEG showed diffuse or focal slow wave activity in 68% of patients, especially with visual hallucinations (85%). Neurological symptoms completely resolved in 78% of patients within 6 (IQR 3-10) days, following aggressive treatment and glucose normalization. CONCLUSIONS: Our results suggest neuronal dysfunction on a metabolic basis as the leading cause of acute neurological deficits in NKHHS. Despite the generally favorable prognosis, prompt identification and aggressive treatment are crucial to avoid irreversible damage. Larger cohort studies are needed to confirm our findings
Local well-posedness for the space-time Monopole equation in Lorenz gauge
It is known from the work of Czubak that the space-time Monopole equation is
locally well-posed in the Coulomb gauge for small initial data in
for . Here we prove local well-posedness for
arbitrary initial data in with in the Lorenz gauge.Comment: To appear in NoDE
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