PENGARUH KUALITAS SISTEM DAN INFORMASI PADA SISTEM INFORMASI PEMBELAJARAN ONLINE TERHADAP MINAT PENGGUNA DAN PENGGUNAAN SISTEM (STUDI KASUS: SIMPONI AMIK MDP, STMIK GI MDP DAN STIE MDP)

System Quality and Information Quality are twodimensions which are interrelated in the Information Technologies’s application usage. Those both qualities determinethe output wich is created from electronic learning system as one of the utilization of IT’s ineducation.Because of that, the development and inovation in electronic learning systems are absolutely done by the education institute.Nowadays, universities are also competing to increase the benefit of IT’s in learning-teaching system based on IT.Some of universities held and organize electronic learning as an additionalactivitiesin its lesson as they presented in class regularly.AMIK MDP,STMIK GI MDP and STIE MDP are currently applied these system in their academic lesson activities.These  research aimed to determine the influence ofSystem Quality and Information Quality to the User Interest and System Usage of online learning system in SIMPONI AMIK MDP, STMIK GI MDP, and STIE MDP.Authors use questionaire method in these data collection, the Structurel Equation Modelling(SEM) method and SmartPLS V2.0M3 assistance are done in processing and data analize.These research is expecting that the authors can give they contribution to the management in what shall be taken for the next step decision in internet utillization by students in AMIK MDP,STMIK GI MDP, and STIE MDP to maximize the academic process

PENGARUH KUALITAS SISTEM DAN INFORMASI PADA SISTEM INFORMASI PEMBELAJARAN ONLINE TERHADAP MINAT PENGGUNA DAN PENGGUNAAN SISTEM (STUDI KASUS: SIMPONI AMIK MDP, STMIK GI MDP DAN STIE MDP)

System Quality and Information Quality are twodimensions which are interrelated in the Information Technologies’s application usage. Those both qualities determinethe output wich is created from electronic learning system as one of the utilization of IT’s ineducation.Because of that, the development and inovation in electronic learning systems are absolutely done by the education institute.Nowadays, universities are also competing to increase the benefit of IT’s in learning-teaching system based on IT.Some of universities held and organize electronic learning as an additionalactivitiesin its lesson as they presented in class regularly.AMIK MDP,STMIK GI MDP and STIE MDP are currently applied these system in their academic lesson activities.These  research aimed to determine the influence ofSystem Quality and Information Quality to the User Interest and System Usage of online learning system in SIMPONI AMIK MDP, STMIK GI MDP, and STIE MDP.Authors use questionaire method in these data collection, the Structurel Equation Modelling(SEM) method and SmartPLS V2.0M3 assistance are done in processing and data analize.These research is expecting that the authors can give they contribution to the management in what shall be taken for the next step decision in internet utillization by students in AMIK MDP,STMIK GI MDP, and STIE MDP to maximize the academic process

Discriminating between Cognitive and Supportive Group Therapies for Chronic Mental Illness

This descriptive and comparative study employed a Q-sort process to describe common factors of therapy in two group therapies for inpatients with chronic mental illness. While pharmacological treatments for chronic mental illness are prominent, there is growing evidence that cognitive therapy is also efficacious. Groups examined were part of a larger study comparing the added benefits of cognitive versus supportive group therapy to the treatment milieu. In general, items described the therapist’s attitudes and behaviors, the participants’ attitudes and behaviors, or the group interactions. Results present items that were most and least characteristic of each therapy and items that discriminate between the two modalities. Therapists in both groups demonstrated good therapy skills. However, the cognitive group was described as being more motivated and active than the supportive group, indicating that the groups differed in terms of common as well as specific factors of treatment

Emergent Properties of Tumor Microenvironment in a Real-life Model of Multicell Tumor Spheroids

Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the internal workings and organization of tumors at a critical phase of their development. To this end, we have developed a computer program that integrates the behavior of individual cells and their interactions with other cells and the surrounding environment. It is based on a quantitative description of metabolism, growth, proliferation and death of single tumor cells, and on equations that model biochemical and mechanical cell-cell and cell-environment interactions. The program reproduces existing experimental data on spheroids, and yields unique views of their microenvironment. Simulations show complex internal flows and motions of nutrients, metabolites and cells, that are otherwise unobservable with current experimental techniques, and give novel clues on tumor development and strong hints for future therapies.Comment: 20 pages, 10 figures. Accepted for publication in PLOS One. The published version contains links to a supplementary text and three video file

Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine

The ability of the bioreductive drugs AQ4N and tirapazamine to enhance the anti-tumour effect of cyclophosphamide was assessed in three murine tumour models. In male BDF mice implanted with the T50/80 mammary carcinoma, AQ4N (50–150 mg kg−1) in combination with cyclophosphamide (100 mg kg−1) produced an effect equivalent to a single 200 mg kg−1dose of cyclophosphamide. Tirapazamine (25 mg kg−1) in combination with cyclophosphamide (100 mg kg−1) produced an effect equivalent to a single 150 mg kg−1dose of cyclophosphamide. In C3H mice implanted with the SCCVII or RIF-1 tumours, enhancement of tumour cell killing was found with both drugs in combination with cyclophosphamide (50–200 mg kg−1); AQ4N (50–200 mg kg−1) produced a more effective combination than tirapazamine (12.5–50 mg kg−1). Unlike tirapazamine, which showed a significant increase in toxicity to bone marrow cells, the combination of AQ4N (100 mg kg−1) 6 h prior to cyclophosphamide (100 mg kg−1) resulted in no additional toxicity towards bone marrow cells compared to that caused by cyclophosphamide alone. In conclusion, AQ4N gave a superior anti-tumour effect compared to tirapazamine when administered with a single dose of cyclophosphamide (100 mg kg−1). © 2000 Cancer Research Campaig

Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines?

The bioreductive drug tirapazamine (TPZ, SR 4233, WIN 59075) is a lead compound in a series of potent cytotoxins that selectively kill hypoxic rodent and human solid tumour cells in vitro and in vivo. Phases II and III trials have demonstrated its efficacy in combination with both fractionated radiotherapy and some chemotherapy. We have evaluated the generality of an enzyme-directed approach to TPZ toxicity by examining the importance of the one-electron reducing enzyme NADPH:cytochrome P450 reductase (P450R) in the metabolism and toxicity of this lead prodrug in a panel of seven human non-small-cell lung cancer cell lines. We relate our findings on TPZ sensitivity in these lung lines with our previously published results on TPZ sensitivity in six human breast cancer cell lines (Patterson et al (1995) Br J Cancer 72: 1144–1150) and with the sensitivity of all these cell types to eight unrelated cancer chemotherapeutic agents with diverse modes of action. Our results demonstrate that P450R plays a significant role in the activation of TPZ in this panel of lung lines, which is consistent with previous observations in a panel of breast cancer cell lines (Patterson et al (1995) Br J Cancer 72: 1144–1150; Patterson et al (1997) Br J Cancer 76: 1338–1347). However, in the lung lines it is likely that it is the inherent ability of these cells to respond to multiple forms of DNA damage, including that arising from P450R-dependent TPZ metabolism, that underlies the ultimate expression of toxicity. © 1999 Cancer Research Campaig