Large constellations of small satellites: A survey of near future challenges and missions

Constellations of satellites are being proposed in large numbers; most of them are expected to be in orbit within the next decade. They will provide communication to unserved and underserved communities, enable global monitoring of Earth and enhance space observation. Mostly enabled by technology miniaturization, satellite constellations require a coordinated effort to face the technological limits in spacecraft operations and space traffic. At the moment in fact, no cost-effective infrastructure is available to withstand coordinated flight of large fleets of satellites. In order for large constellations to be sustainable, there is the need to efficiently integrate and use them in the current space framework. This review paper provides an overview of the available experience in constellation operations and statistical trends about upcoming constellations at the moment of writing. It highlights also the tools most often proposed in the analyzed works to overcome constellation management issues, such as applications of machine learning/artificial intelligence and resource/infrastructure sharing. As such, it is intended to be a useful resource for both identifying emerging trends in satellite constellations, and enabling technologies still requiring substantial development efforts

Absence of FGFR3–TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration

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Surgical site infection after caesarean section. Space for post-discharge surveillance improvements and reliable comparisons

Surgical site infections (SSI) after caesarean section (CS) represent a substantial health system concern. Surveying SSI has been associated with a reduction in SSI incidence. We report the findings of three (2008, 2011 and 2013) regional active SSI surveillances after CS in community hospital of the Latium region determining the incidence of SSI. Each CS was surveyed for SSI occurrence by trained staff up to 30 post-operative days, and association of SSI with relevant characteristics was assessed using binomial logistic regression. A total of 3,685 CS were included in the study. A complete 30 day post-operation follow-up was achieved in over 94% of procedures. Overall 145 SSI were observed (3.9% cumulative incidence) of which 131 (90.3%) were superficial and 14 (9.7%) complex (deep or organ/space) SSI; overall 129 SSI (of which 89.9% superficial) were diagnosed post-discharge. Only higher NNIS score was significantly associated with SSI occurrence in the regression analysis. Our work provides the first regional data on CS-associated SSI incidence, highlighting the need for a post-discharge surveillance which should assure 30 days post-operation to not miss data on complex SSI, as well as being less labour intensive

Benthic foraminiferal ultrastructural alteration induced by heavy metals

Heavy metals are known to cause deleterious effects on biota because of their toxicity, persistence and bioaccumulation. Here, we briefly document the ultrastructural changes observed in the miliolid foraminifer Pseudotriloculina rotunda (d\u27Orbigny in Schlumberger, 1893) and in the perforate calcareous species Ammonia parkinsoniana (d\u27Orbigny, 1839) induced by exposure to one of three heavy metals (zinc, lead, or mercury). The exposure of these two benthic foraminiferal species to the selected heavy metals appears to promote cytological alterations and organelle degeneration. These alterations include a thickening of the inner organic lining, an increase in number and size of lipid droplets, mitochondrial degeneration, and degradation vacuoles and residual body proliferation. Some of these alterations, including the thickening of the inner organic lining and the proliferation of lipids, might represent defense mechanisms against heavy metal-induced stress

Biogeochemistry, grain size and mineralogy of the Central and Southern Adriatic Sea sediments: a review.

Volume 26 Supplement 1, January 2010

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients

Job demands-resources model in an Italian sample of academics

In recent decades, universities in many countries have undergone important changes that have profoundly affected the working life of academics (Winefield et al., 2008), making it more demanding and stressful (Kinman et al., 2006). In Italy, these changes – directly linked to the university reform (Law 240/2010) – are now highly critical (Pellerey, 2011; Sundry Authors, 2010).This study investigates health impairment and motivational outcomes of Italian academics in the theoretical framework of the job demands-resources model (JD-R model; Bakker & Demerouti, 2007; Demerouti, et al., 2001). The robustness of the JD-R model was already tested and demonstrated in different national and occupational contexts (Llorens, et al. 2006), and in the context of academics (Bakker et al., 2010; Boyd et al., 2011)