Nonperturbative Entangling Gates between Distant Qubits Using Uniform Cold Atom Chains

We propose a new fast scalable method for achieving a two-qubit entangling gate between arbitrary distant qubits in a network by exploiting dispersionless propagation in uniform chains. This is achieved dynamically by switching on a strong interaction between the qubits and a bus formed by a nonengineered chain of interacting qubits. The quality of the gate scales very efficiently with qubit separations. Surprisingly, a sudden switching of the couplings is not necessary. Moreover, our gate mechanism works for multiple gate operations without resetting the bus. We propose a possible experimental realization in cold atoms trapped in optical lattices and near field Fresnel trapping potentials

Integration of flux tower data and remotely sensed data into the SCOPE simulator: A Bayesian approach:abstract

Quantification of gross primary production (GPP) together with the continuous monitoring of i ts temporal variations are indispensable to obtain reliable data for indicating the capacity of f orests to sequester carbon. GPP can be quantified using two sources: (a) process-based simulator (PBS); and (b) flux tower measurements of the net ecosystem exchange (NEE) of CO2. Additionally, remotely sensed optical data, which can be linked to the vegetation properties, carry valuable information to express canopy photosynthesis (i.e., GPP). A PBS has an advantage over flux tower and remotely sensed optical data because it can be run at time scales beyond the limit of direct measurements. Simulation of GPP by PBS at a high accuracy, however, depends upon how well the parameterization is achieved. A process-based simulator SCOPE (Soil-Canopy-Observation of Photosynthesis and Energy balance) links top of canopy observations of radiance with land surface processes (that include GPP simulation). Some parameters of SCOPE are difficult to obtain from field observations. Reliable estimates of parameters can, however, be obtained using calibration against observations of output. In this study, we present a Bayesian framework to calibrate SCOPE simulator against the estimates of GPP (separated from NEE), and the top of canopy reflectance retrieved from the remote sensing images. This framework has been tested for spruce dominated forest site at Bílý Kříž, Czech Republic. We focus on the retrieval of parameters, on which GPP are expected to be most sensitive, such as leaf area index, leaf chlorophyll content, leaf water content, leaf dry matter content, senescent material content, maximum carboxylation capacity, and stomatal conductance. A Bayesian framework also allowed to estimate the uncertainties of both the SCOPE parameters and the simulated GPP, which is important in the sense that it helps to determine how much confidence can be placed in the results of forest carbon-related studies

Keloid Disease Can Be Inhibited by Antagonizing Excessive mTOR Signaling With a Novel Dual TORC1/2 Inhibitor

Keloid disease (KD) is a fibroproliferative lesion of unknown etiopathogenesis that possibly targets the PI3K/Akt/mTOR pathway. We investigated whether PI3K/Akt/mTOR inhibitor, Palomid 529 (P529), which targets both mammalian target of rapamycin complex 1 (mTORC-1) and mTORC-2 signaling, could exert anti-KD effects in a novel KD organ culture assay and in keloid fibroblasts (KF). Treatment of KF with P529 significantly (P < 0.05) inhibited cell spreading, attachment, proliferation, migration, and invasive properties at a low concentration (5 ng/mL) and induced substantial KF apoptosis when compared with normal dermal fibroblasts. P529 also inhibited hypoxia-inducible factor-1α expression and completely suppressed Akt, GSK3β, mTOR, eukaryotic initiation factor 4E-binding protein 1, and S6 phosphorylation. P529 significantly (P < 0.05) inhibited proliferating cell nuclear antigen and cyclin D and caused considerable apoptosis. Compared with rapamycin and wortmannin, P529 also significantly (P < 0.05) reduced keloid-associated phenotypic markers in KF. P529 caused tissue shrinkage, growth arrest, and apoptosis in keloid organ cultures and substantially inhibited angiogenesis. pS6, pAkt-Ser473, and mTOR phosphorylation were also suppressed in situ. P529 reduced cellularity and expression of collagen, fibronectin, and α-smooth muscle actin (substantially more than rapamycin). These pre-clinical in vitro and ex vivo observations are evidence that the mTOR pathway is a promising target for future KD therapy and that the dual PI3K/Akt/mTOR inhibitor P529 deserves systematic exploration as a candidate agent for the future treatment of KD

Study of Pulsatile Flow in Common Carotid Artery with Different Stenosis' Shapes within Various Wall Conditions

Recently, due to the development of CFD techniques, many attempts have been made to simulate the initiation and progression of atherosclerosis. In recent works, various curves have been suggested to model the stenosis shape. However, little effort has been made to study the importance of the stenosis shape on the flow behavior. In this study, four types of stenosis with asteroid, Gaussian, semi-circle, and sinusoidal shapes were simulated in order to study the effect of the stenosis shape on flow behavior and diagnosis parameters. Shear stress and flow behavior were investigated in the common carotid artery with stenosis severities of 30%, 40%, and 50%. Flow was assumed to be unsteady and the inlet to be a pulsatile flow. Two cases of Newtonian and non-Newtonian fluids were simulated. The no-slip and permeable boundary conditions were imposed on the outer walls. To examine the effect of the location of stenosis, modeling was conducted at various locations. The results showed that the maximum shear stress occurs in the Gaussian stenosis at the opening of the stenosis. Semi-circle, sinus, and asteroid shapes had the next largest shear stress values. Additionally, the location of stenosis had a negligible effect on the maximum shear stress. However, flow resistance increased with increasing the stenosis’s distance from the beginning of the artery. This study indicates that stenosis shape highly affects the flow characteristics, and stenosis severity is not the only parameter that is important. Hence, the stenosis shape should be considered when simulating atherosclerosis

Productivity, quality and economics of four spring wheat (Triticum aestivum L.) cultivars as affected by three cultivation technologies

ArticleManaging farming inputs in wheat production technologies is an issue of paramount importance to attain optimum profitable production. To examine how varying the farming inputs affects the nutrients uptake and productivity of spring wheat (Triticum aestivum L.) cultivars and to determine the economic efficiency of various cultivation technologies, three-year field experiments were laid out at the Russian Research Institute of Agriculture, during the 2015–2017 growing seasons. Experiments were conducted once a year using randomized complete block arranged in a split plot experimental design with three replications, with the cultivation technology treatments (basic, intensive and high intensive technology) as the main plots, and spring wheat cultivars (Zelata, Lubova, Liza and Ester) as the sub-main plots. The highest grain yield (10.8 t ha-1), harvest index (42.9%), gluten content (39.45%) and gluten index (71.17%) observed for spring wheat cultivar Lubova with the moderate application of farming inputs as an intensive cultivation technology. Highest protein content (18.02%) was attained for both intensive and high intensive cultivation technology with the cultivar Lubova, and the highest 1,000 grains weight (46.32 g) was recorded by cultivar Lubova in basic cultivation technology. Applying moderate amount of inputs as an intensive cultivation technology resulted in highest wheat yield and net income

Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneity

<p>Abstract</p> <p>Background</p> <p>Familial keloids have been reported, having either autosomal dominant or autosomal recessive inheritance. We wished to determine the inheritance pattern and phenotype of keloids among multigenerational families, as a prelude to a positional mapping strategy to identify candidate genes.</p> <p>Methods</p> <p>We studied three African American families, one Afro-Caribbean family and one Asian-American family. Phenotyping including assessing all patients for the presence, distribution, and appearance of keloids, together with the timing of keloid onset and provocative factors. The clinical trial was registered at clinicaltrials.gov (NCT 00005802).</p> <p>Results</p> <p>Age of keloid onset varied considerably within families, but commonly occurred by the second decade. The fraction of affected individuals was 38%, 45%, 62%, 67% and 73% among the five families respectively. Keloid severity and morphology differed within and between families. A novel finding is that certain families manifest keloids in distinct locations, with one family showing an excess of extremity keloids and two families showing an excess of axilla-groin keloids.</p> <p>Conclusion</p> <p>Familial keloids appear to most commonly manifest autosomal dominant or semidominant inheritance, and there may be familial patterns of keloid distribution.</p

The frequency of transforming growth factor-TGF-B gene polymorphisms in a normal southern Iranian population

Several single nucleotide polymorphisms (SNPs) of the transforming growth factor-β1 gene (TGFB1) have been reported. Determination of TGFB1 SNPs allele frequencies in different ethnic groups is useful for both population genetic analyses and association studies with immunological diseases. In this study, five SNPs of TGFB1 were determined in 325 individuals from a normal southern Iranian population using polymerase chain reaction-restriction fragment length polymorphism method. This population was in Hardy-Weinberg equilibrium for these SNPs. Of the 12 constructed haplotypes, GTCGC and GCTGC were the most frequent in the normal southern Iranian population. Comparison of genotype and allele frequencies of TGFB SNPs between Iranian and other populations (meta-analysis) showed significant differences, and in this case the southern Iranian population seems genetically similar to Caucasoid populations. However, neighbour-joining tree using Nei's genetic distances based on TGF-β1 allele frequencies showed that southern Iranians are genetically far from people from the USA, Germany, UK, Denmark and the Czech Republic. In conclusion, this is the first report of the distribution of TGFB1 SNPs in an Iranian population and the results of this investigation may provide useful information for both population genetic and disease studies. © 2008 The Authors

The effects of energy metabolism variables on feed efficiency in respiration chamber studies with lactating dairy cows

The objective of the present study was to investigate factors related to variation in feed efficiency (FE) among cows. Data included 841 cow/period observations from 31 energy metabolism studies assembled across 3 research stations. The cows were categorized into low-, medium-, and high-FE groups according to residual feed intake (RFI), residual energy-corrected milk (RECM), and feed conversion efficiency (FCE). Mixed model regression was conducted to identify differences among the efficiency groups in animal and energy metabolism traits. Partial regression coefficients of both RFI and RECM agreed with published energy requirements more closely than cofficients derived from production experiments. Within RFI groups, efficient (Low-RFI) cows ate less, had a higher digestibility, produced less methane (CH4) and heat, and had a higher efficiency of metabolizable energy (ME) utilization for milk production. High-RECM (most efficient) cows produced 6.0 kg/d more of energy-corrected milk (ECM) than their Low-RECM (least efficient) contemporaries at the same feed intake. They had a higher digestibility, produced less CH4 and heat, and had a higher efficiency of ME utilization for milk production. The contributions of improved digestibility, reduced CH4, and reduced urinary energy losses to increased ME intake at the same feed intake were 84, 12, and 4%, respectively. For both RFI and RECM analysis, increased metabolizability contributed to approximately 35% improved FE, with the remaining 65% attributed to the greater efficiency of utilization of ME. The analysis within RECM groups suggested that the difference in ME utilization was mainly due to the higher maintenance requirement of Low-RECM cows compared with Medium- and High-RECM cows, whereas the difference between Medium- and High-RECM cows resulted mainly from the higher efficiency of ME utilization for milk production in High-RECM cows. The main difference within FCE (ECM/DMI) categories was a greater (8.2 kg/d) ECM yield at the expense of mobilization in High-FCE cows compared with Low-FCE cows. Methane intensity (CH4/ECM) was lower for efficient cows than for inefficient cows. The results indicated that RFI and RECM are different traits. We concluded that there is considerable variation in FE among cows that is not related to dilution of maintenance requirement or nutrient partitioning. Improving FE is a sustainable approach to reduce CH4 production per unit of product, and at the same time improve the economics of milk production.202

Demographic parameters of the cotton aphid, Aphis gossypii (Hom.: Aphididae), population in cotton fields of Gorgan

Age-specific life table parameters of Aphis gossypii Glover (Homoptera: Aphididae), one of the major pests of cotton in the Gorgan region, were determined on Gossypium hirsutum L. at different periods during 2002 and 2003 growing seasons. Population projection matrices were used to calculate aphid population elasticity and sensitivities to the changes of aphid survival and fecundity rates. A. gossypii attained its optimum growth and reproduction rates at early season (July). At this condition, the net reproductive rate (17.16 female/female), intrinsic rate of increase (0.349 female/female/time) and finite rate of increase (1.42) were the largest, while population doubling time (1.96 days) was the smallest. At mid and late seasons (August and September) the intrinsic rates of increase were 0.257 and 0.208, respectively. The lowest intrinsic rate of increase (0.073) was observed during a short period in early August. Survival curves of the aphid population were near to Deevyâs type III. The elasticity and sensitivity of nymph survival rates were higher than the adult fecundity rates and decreased relative to the age increasing

Effect of family-based cognitive behavioral therapy in modification of self-image associated with obesity among children

Background and purpose: The purpose of this study was to investigate the effect of family-based cognitive behavioral therapy in modification of self-image associated with obesity in children. Materials and methods: A randomized controlled trial was performed in children with obesity (BMI � 95th percentile(aged 8-15 years old. Using convenience sampling, the participants were recruited from Children Hospital and Morsali clinic in Arak, Iran. They were randomly assigned to either the experimental group (n= 15) or control group (n= 15). The children in experimental group received family-based cognitive behavioral therapy (6 group sessions) and their parents attended 5 group sessions. All participants completed Body Parts Satisfaction Scale-Revised (BPSS-R) and Standard Figural Stimuli Scale (SFSS) in pretest, posttest and follow-up. BMI was calculated in all three stages. Results: Family-based cognitive-behavioral therapy was found effective in improving the body parts satisfaction (P=0.023) and body image satisfaction (P=0.0001). The improvement maintained only in body image at follow-up (P=0.0001). Conclusion: According to these results, family-based cognitive behavioral therapy is effective in modification of self-image in children. © 2016, Mazandaran University of Medical Sciences. All rights reserved