Children\u27s cognitive processing of abuse as described in investigative interviews.

A great deal of research has examined ways in which investigative interviewers can elicit accurate information from children. More recently, research has studied children’s own thoughts or comprehension of abuse, and how these types of statements relate to disclosure, others’ perceptions of child witnesses, and psychological trauma. However, little research has investigated multiple types of children’s thoughts about abuse as they occur in an actual investigative interview. The current study examined seven types of statements children made about their abuse in a sample of 86 transcripts of investigative interviews conducted by Child Protective Services and a police department in a mid-sized Ontario city. Children interviewed ranged from 4- to 17-years-of-age, with approximately equal numbers of males and females. Type of abuse disclosed in the interviews ranged from verbal abuse to sexual abuse. Two coders independently coded each transcript for seven statement types: expected consequences of disclosure, actual consequences of disclosure, minimization, justification for either self, perpetrator, or other, and blame. Whether the statements were elicited by an interviewer prompt or mentioned spontaneously by the child was also coded. Results demonstrated that children blamed the perpetrator more than any other statement type, consistent with previous research. Analyses also revealed a significant relationship between abuse type and children’s statements, and alleged perpetrator and children’s statements. Results from the current study have implications for disclosure, treatment of psychological trauma, and how parents, social workers, police officers, attorneys, and judges view children’s statements

Information Systems Undergraduate Degree Project: Gaining a Better Understanding of the Final Year Project Module

The place of an individual project in the final year of Information Systems (IS) undergraduate degrees at UK universities is well established. In this paper we compare the final year project modules at four UK universities: the University of Brighton, the University of South Wales, University of West London and the University of Westminster. We find that the aims of the projects are similar, emphasising the application of the knowledge and skills from the taught element of their course in a complex development project, often including interactions with a real client. Although we show in this analysis that projects serve a similar purpose in the IS degree courses, the associated learning outcomes and the assessment practice varies across the institutions. We identify some gaps in the skills and abilities that are not being assessed. In further work we are planning to consult final year students undertaking their projects and their supervisors, in order to gain an understanding of how project assessment criteria are actually put to use

Three-dimensionality in quasi-two dimensional flows: recirculations and barrel effects

A scenario is put forward for the appearance of three-dimensionality both in quasi-2D rotating flows and quasi-2D magnetohydrodynamic (MHD) flows. We show that 3D recirculating flows and currents originate in wall boundary layers and that, unlike in ordinary hydrodynamic flows, they cannot be ignited by confinement alone. They also induce a second form of three-dimensionality with quadratic variations of velocities and current across the channel. This scenario explains both the common tendency of these flows to two-dimensionality and the mechanisms of the recirculations through a single formal analogy covering a wide class of flow including rotating and MHD flows. These trans-disciplinary effects are thus active in atmospheres, oceans or the cooling blankets of nuclear fusion reactors.Comment: 6 pages, 1 Figur

Mock Catalogs for UHECR Studies

We provide realistic mock-catalogs of cosmic rays above 40 EeV, for a pure proton composition, assuming their sources are a random subset of ordinary galaxies in a simulated, volume-limited survey, for various choices of source density: 10^-3.5 Mpc^-3, 10^-4.0 Mpc^-3 and 10^-4.5 Mpc^-3. The spectrum at the source is taken to be E^-2.3 and the effects of cosmological redshifting as well as photo-pion and e^+ e^- energy losses are included.Comment: 7 pages, 4 figure

The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines

Copyright @ 2014 the authors. This article is made available through the Brunel Open Access Publishing Fund. It is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Mammalian telomeric DNA consists of tandem repeats of the sequence TTAGGG associated with a specialized set of proteins, known collectively as Shelterin. These telosomal proteins protect the ends of chromosomes against end-to-end fusion and degradation. Short telomeres in breast cancer cells confer telomere dysfunction and this can be related to Shelterin proteins and their level of expression in breast cancer cell lines. This study investigates whether expression of Shelterin and Shelterin-associated proteins are altered, and influence the protection and maintenance of telomeres, in breast cancer cells. 5-aza-2'-deoxycytidine (5-aza-CdR) and trichostatin A (TSA) were used in an attempt to reactivate the expression of silenced genes. Our studies have shown that Shelterin and Shelterin-associated genes were down-regulated in breast cancer cell lines; this may be due to epigenetic modification of DNA as the promoter region of POT1 was found to be partially methylated. Shelterin genes expression was up-regulated upon treatment of 21NT breast cancer cells with 5-aza-CdR and TSA. The telomere length of treated 21NT cells was measured by q-PCR showed an increase in telomere length at different time points. Our studies have shown that down-regulation of Shelterin genes is partially due to methylation in some epithelial breast cancer cell lines. Removal of epigenetic silencing results in up-regulation of Shelterin and Shelterin-associated genes which can then lead to telomere length elongation and stability

Feedback control architecture & the bacterial chemotaxis network

Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to ‘reset’ (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a ‘cascade control’ feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance

New biostratigraphic, magnetostratigraphic and isotopic insights into the Middle Eocene Climatic Optimum in low latitudes

The Middle Eocene Climatic Optimum (MECO) was a warming event that interrupted the long-term Eocene cooling trend. While this event is well documented at high southern and mid-latitudes, it is poorly known from low latitudes and its timing and duration are not well constrained because of problems of hiati, microfossil preservation and weak magnetic polarity in key sedimentary sections. Here, we report the results of a study designed to improve the bio-, magneto- and chemostratigraphy of the MECO interval using high-resolution records from two low-latitude sections in the Atlantic Ocean, Ocean Drilling Program (ODP) Sites 1051 and 1260. We present the first detailed benthic foraminiferal stable isotope records of the MECO from the low latitudes as well as the biostratigraphic counts of Orbulinoides beckmanni and new magnetostratigraphic results. Our data demonstrate a ~ 750 kyr-long duration for the MECO characterized by increasing δ13C and decreasing δ18O, with minimum δ18O values lasting ~ 40 kyr at 40.1 Ma coincident with a short-lived negative δ13C excursion. Thereafter, δ18O and δ13C values recover rapidly. The shift to minimum δ18O values at 40.1 Ma is coincident with a marked increase in the abundance of the planktonic foraminifera O. beckmanni, consistent with its inferred warm-water preference. O. beckmanni is an important Eocene biostratigraphic marker, defining planktonic foraminiferal Zone E12 with its lowest and highest occurrences (LO and HOs). Our new records reveal that the LO of O. beckmanni is distinctly diachronous, appearing ~ 500 kyr earlier in the equatorial Atlantic than in the subtropics (40.5 versus 41.0 Ma). We also show that, at both sites, the HO of O. beckmanni at 39.5 Ma is younger than the published calibrations, increasing the duration of Zone E12 by at least 400 kyr. In accordance with the tropical origins of O. beckmanni, this range expansion to higher latitudes may have occurred in response to sea surface warming during the MECO and subsequently disappeared with cooling of surface waters

The worldwide costs of marine protected areas

Declines in marine harvests, wildlife, and habitats have prompted calls at both the 2002 World Summit on Sustainable Development and the 2003 World Parks Congress for the establishment of a global system of marine protected areas (MPAs). MPAs that restrict fishing and other human activities conserve habitats and populations and, by exporting biomass, may sustain or increase yields of nearby fisheries. Here we provide an estimate of the costs of a global MPA network, based on a survey of the running costs of 83 MPAs worldwide. Annual running costs per unit area spanned six orders of magnitude, and were higher in MPAs that were smaller, closer to coasts, and in high-cost, developed countries. Models extrapolating these findings suggest that a global MPA network meeting the World Parks Congress target of conserving 20–30% of the world’s seas might cost between $5 billion and$19 billion annually to run and would probably create around one million jobs. Although substantial, gross network costs are less than current government expenditures on harmful subsidies to industrial fisheries. They also ignore potential private gains from improved fisheries and tourism and are dwarfed by likely social gains from increasing the sustainability of fisheries and securing vital ecosystem services