Health-related quality of life in relation to shark symptomatic and radiographic definitions of knee osteoarthritis : data from Osteoarthritis Initiative (OAI) 4-year follow- up study

Background: The purpose was to quantify the decrement in health utility (referred as disutility) associated with knee osteoarthritis (OA) and different symptomatic and radiographic uni- and bilateral definitions of knee OA in a repeated measures design of persons with knee OA or at increased risk of developing knee OA. Methods: Data were obtained from the Osteoarthritis Initiative database. SF-12 health-related quality of life was converted into SF-6D utilities, and were then handled as the health utility loss by subtracting 1.000 from the utility score, yielding a negative value (disutility). Symptomatic OA was defined by radiographic findings (Kellgren-Lawrence, K-L, grade >= 2) and frequent knee pain in the same knee. Radiographic OA was defined by five different definitions (K-L >= 2 unilaterally / bilaterally, or the highest / mean / combination of K-L grades of both knees). Repeated measures generalized estimating equation (GEE) models were used to investigate disutility in relation to these different definitions. Results: Utility decreased with worsening of symptomatic or radiographic status of knee OA. The participants with bilateral and unilateral symptomatic knee OA had 0.03 (p <0.001) and 0.02 (p <0.001) points lower utility scores, respectively, compared with the reference group. The radiographic K-L grade 4 defined as the mean or the highest grade of both knees was related to a decrease of 0.04 (p <0.001) and 0.03 (p <0.001) points in utility scores, respectively, compared to the reference group. Conclusions: Knee OA is associated with diminished health-related quality of life. Health utility can be quantified in relation to both symptomatic and radiographic uni- and bilateral definitions of knee OA, and these definitions are associated with differing disutilities. The performance of symptomatic definition was better, indicating that pain experience is an important factor in knee OA related quality of life.Peer reviewe

Review of the Properties of the W Boson at LEP, and the Precision Determination of its Mass

We review the precision measurement of the mass and couplings of the W Boson at LEP. The total and differential W+W- cross section is used to extract the WWZ and WWgamma couplings. We discuss the techniques used by the four LEP experiments to determine the W mass in different decay channels, and present the details of methods used to evaluate the sources of systematic uncertainty.Comment: 97 page

Charged Scalar Particles and τ\tau Leptonic Decay

Charged scalar particles introduced in some extensions of the standard model can induce $\tau$ leptonic decay at tree level. We find that with some charged SU(2)-singlet scalar particles, like ones introduced in Zee-type models, $\tau$ leptonic decay width is always smaller than what is predicted by the standard model, therefore they may offer a natural solution to $\tau$ decay puzzle. To be more specific, we examine some Zee-type models in detail to see if at the same time they are acceptable in particle physics, cosmology and astrophysics. It is shown that $\tau$ decay data do put some constrains on these models.Comment: ICTP Report No. IC/93/31, 12 pages, Latex, one figure is not included, it is available upon deman

Eight-year trajectories of changes in health-related quality of life in knee osteoarthritis : Data from the Osteoarthritis Initiative (OAI)

Background Knee osteoarthritis (OA) worsens health-related quality of life (HRQoL) but the symptom pathway varies from person to person. We aimed to identify groups of people with knee OA or at its increased risk whose HRQoL changed similarly. Our secondary aim was to evaluate if patient-related characteristics, incidence of knee replacement (KR) and prevalence of pain medication use differed between the identified HRQoL trajectory groups. Methods Eight-year follow-up data of 3053 persons with mild knee OA or at increased risk were obtained from the public Osteoarthritis Initiative (OAI) database. Group-based trajectory modeling was used to identify patterns of experiencing a decrease of >= 10 points (Minimal Important Change, MIC) in the Quality of Life subscale of the Knee injury and Osteoarthritis Outcome Score compared to baseline. Multinomial logistic regression, Cox regression and generalized estimating equation models were used to study secondary aims. Results Four HRQoL trajectory groups were identified. Persons in the 'no change' group (62.9%) experienced no worsening in HRQoL. 'Rapidly' (9.5%) and 'slowly' worsening (17.1%) groups displayed an increasing probability of experiencing the MIC in HRQoL. The fourth group (10.4%) had 'improving' HRQoL. Female gender, higher body mass index, smoking, knee pain, and lower income at baseline were associated with belonging to the 'rapidly worsening' group. People in 'rapidly' (hazard ratio (HR) 6.2, 95% confidence interval (CI) 3.6-10.7) and 'slowly' worsening (HR 3.4, 95% CI 2.0-5.9) groups had an increased risk of requiring knee replacement. Pain medication was more rarely used in the 'no change' than in the other groups. Conclusions HRQoL worsening was associated with several risk factors; surgical and pharmacological interventions were more common in the poorer HRQoL trajectory groups indicating that HRQoL does reflect the need for OA treatment. These findings may have implications for targeting interventions to specific knee OA patient groups.Peer reviewe

FU Orionis disk outburst: evidence for a gravitational instability scenario triggered in a magnetically dead zone

Context: FUors outbursts are a crucial stage of accretion in young stars. However a complete mechanism at the origin of the outburst still remains missing. Aims: We aim at constraining the instability mechanism in FU Orionis star itself, by directly probing the size and the evolution in time of the outburst region with near-infrared interferometry, and to confront it to physical models of this region. Methods: FU Orionis has been a regular target of near-infrared interferometry. In this paper, we analyze more than 20 years of interferometric observations to perform a temporal monitoring of the region of the outburst, and compare it to the spatial structure deduced from 1D MHD simulations. Results: We measure from the interferometric observations that the size variation of the outburst region is compatible with a constant or slightly decreasing size over time in the H and K band. The temporal variation and the mean sizes are consistently reproduced by our 1D MHD simulations. We find that the most compatible scenario is a model of an outburst occurring in a magnetically layered disk, where a Magneto-Rotational Instability (MRI) is triggered by a Gravitational Instability (GI) at the outer edge of a dead-zone. The scenario of a pure Thermal Instability (TI) fails to reproduce our interferometric sizes since it can only be sustained in a very compact zone of the disk <0.1 AU. The scenario of MRI-GI could be compatible with an external perturbation enhancing the GI, such as tidal interactions with a stellar companion, or a planet at the outer edge of the dead-zone. Conclusions: The layered disk model driven by MRI turbulence is favored to interpret the spatial structure and temporal evolution of FU Orionis outburst region. Understanding this phase gives a crucial link between the early phase of disk evolution and the process of planet formation in the first inner AUs.Comment: Accepted for publication in A&

Modelling the dispersion of particle numbers in five European cities

We present an overview of the modelling of particle number concentrations (PNCs) in five major European cities, namely Helsinki, Oslo, London, Rotterdam, and Athens, in 2008. Novel emission inventories of particle numbers have been compiled both on urban and European scales. We used atmospheric dispersion modelling for PNCs in the five target cities and on a European scale, and evaluated the predicted results against available measured concentrations. In all the target cities, the concentrations of particle numbers (PNs) were mostly influenced by the emissions originating from local vehicular traffic. The influence of shipping and harbours was also significant for Helsinki, Oslo, Rotterdam, and Athens, but not for London. The influence of the aviation emissions in Athens was also notable. The regional background concentrations were clearly lower than the contributions originating from urban sources in Helsinki, Oslo, and Athens. The regional background was also lower than urban contributions in traffic environments in London, but higher or approximately equal to urban contributions in Rotterdam. It was numerically evaluated that the influence of coagulation and dry deposition on the predicted PNCs was substantial for the urban background in Oslo. The predicted and measured annual average PNCs in four cities agreed within approximatelyPeer reviewe

Study of Inclusive J/psi Production in Two-Photon Collisions at LEP II with the DELPHI Detector

Inclusive J/psi production in photon-photon collisions has been observed at LEP II beam energies. A clear signal from the reaction gamma gamma -> J/psi+X is seen. The number of observed N(J/psi -> mu+mu-) events is 36 +/- 7 for an integrated luminosity of 617 pb^{-1}, yielding a cross-section of sigma(J/psi+X) = 45 +/- 9 (stat) +/- 17 (syst) pb. Based on a study of the event shapes of different types of gamma gamma processes in the PYTHIA program, we conclude that (74 +/- 22)% of the observed J/psi events are due to `resolved' photons, the dominant contribution of which is most probably due to the gluon content of the photon.Comment: 13 pages, 8 figures, Accepted by Phys. Lett.

Probing the Inner Disk Emission of the Herbig Ae Stars HD 163296 and HD 190073

This is the author accepted manuscript. The final version is available from American Astronomical Society / IOP Publishing via the DOI in this record.The physical processes occurring within the inner few astronomical units of proto-planetary disks surrounding Herbig Ae stars are crucial to setting the environment in which the outer planet-forming disk evolves and put critical constraints on the processes of accretion and planet migration. We present the most complete published sample of high angular resolution H- and K-band observations of the stars HD 163296 and HD 190073, including 30 previously unpublished nights of observations of the former and 45 nights of the latter with the CHARA long-baseline interferometer, in addition to archival VLTI data. We confirm previous observations suggesting significant near-infrared emission originates within the putative dust evaporation front of HD 163296 and show this is the case for HD 190073 as well. The H- and K-band sizes are the same within (3±3)% for HD 163296 and within (6±10)% for HD 190073. The radial surface brightness profiles for both disks are remarkably Gaussian-like with little or no sign of the sharp edge expected for a dust evaporation front. Coupled with spectral energy distribution analysis, our direct measurements of the stellar flux component at H and K bands suggest that HD 190073 is much younger (<400 kyr) and more massive (~5.6 M⊙) than previously thought, mainly as a consequence of the new Gaia distance (891 pc).JDM and BRS acknowledge support from NSF-AST 1506540 and AA acknowledges support from NSF-AST 1311698. CLD, AK, and SK acknowledge support from the ERC Starting Grant “ImagePlanetFormDiscs” (Grant Agreement No. 639889), STFC Rutherford fellowship/grant (ST/J004030/1, ST/K003445/1) and Philip Leverhulme Prize (PLP2013-110). FB acknowledges support from NSF-AST 1210972 and 1445935. MS acknowledges support by the NASA Origins of Solar Systems grant NAG5-9475, and NASA Astrophysics Data Program contract NNH05CD30C. The CHARA Array is supported by the National Science Foundation under Grant No. AST-1211929, AST-1636624, and AST-1715788. Institutional support has been provided from the GSU College of Arts and Sciences and the GSU Office of the Vice President for Research and Economic Development