Homeownership and Wealth in Switzerland and Germany

Property wealth represents the most important wealth component in nearly all OECD countries. Homeownership is linked to wealth accumulation in several ways: Wealthier households are more likely to buy a house or apartment, home owners tend to save more and rising house values typically yield higher returns than money in a bank account. Moreover, owners can borrow on a mortgage to finance, e.g., the formation of an enterprise or other economic activities. At the aggregate level, these relations can explain why countries with low rates of homeownership tend to have a high wealth inequality. This paper looks at wealth and homeownership in Germany and Switzerland. These countries show the lowest proportion of owner-occupiers in Europe and a high wealth inequality. We analyse to what extent this high inequality can be explained by homeownership status. In the first part of this contribution, we review explanations for the low share of owner-occupiers in the two countries. In the second part, we analyse wealth and homeownership empirically using data of the SHP and the German Socio-Economic Panel (SOEP) from 2012. We make use of decomposition methods to analyse how renter and owner households differ in wealth levels and wealth inequality

Insulin Restores Gestational Diabetes Mellitus–Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

OBJECTIVE-To determine whether insulin reverses gestational diabetes mellitus (GDM)-reduced expression and activity of human equilibrative nucleoside transporters 1 (hENT1) in human umbilical vein endothelium cells (HUVECs).RESEARCH DESIGN AND METHODS-Primary cultured HUVECs from full-term normal (n = 44) and diet-treated GDM (n = 44) pregnancies were used. Insulin effect was assayed on hENT1 expression (protein, mRNA, SLC29A1 promoter activity) and activity (initial rates of adenosine transport) as well as endothelial nitric oxide (NO) synthase activity (serine(1177) phosphorylation, L-citrulline formation). Adenosine concentration in culture medium and umbilical vein blood (high-performance liquid chromatography) as well as insulin receptor A and B expression (quantitative PCR) were determined. Reactivity of umbilical vein rings to adenosine and insulin was assayed by wire myography. Experiments were in the absence or presence of L-N-G-nitro-L-arginine methyl ester (L-NAME; NO synthase inhibitor) or ZM-241385 (an A(2A)-adenosine receptor antagonist).RESULTS-Umbilical vein blood adenosine concentration was higher, and the adenosine- and insulin-induced NO/endothelium-dependent umbilical vein relaxation was lower in GDM. Cells from GDM exhibited increased insulin receptor A isoform expression in addition to the reported NO-dependent inhibition of hENT1-adenosine transport and SLC29A1 reporter repression, and increased extracellular concentration of adenosine and NO synthase activity. Insulin reversed all these parameters to values in normal pregnancies, an effect blocked by ZM-241385 andCONCLUSIONS-GDM and normal pregnancy HUVEC phenotypes are differentially responsive to insulin, a phenomenon where insulin acts as protecting factor for endothelial dysfunction characteristic of this syndrome. Abnormal adenosine plasma levels, and potentially A2A-adenosine receptors and insulin receptor A, will play crucial roles in this phenomenon in GDM. Diabetes 60:1677-1687, 2011Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT), ChileComision Nacional de Investigacion en Ciencia y Tecnologia (CONICYT), AnillosFellowship Apoyo de Tesis CONICYT, ChileDireccion de InvestigacionVicerrectoria Academica (Anillos)Pontificia Universidad Catolica de Chile, Universidad de Antofagasta, Antofagasta, ChileDireccion de Investigacion (DIUC)Universidad de Concepcion, Concepcion, ChileCONICYT-PhD (Chile)Faculty of Medicine, Pontificia Universidad Catolica de Chile-PhD fellowshi

A HIGH RESOLUTION TEMPERATURE CLIMATOLOGY FOR THE GREATER ALPINE REGION (GAR)

The Greater Alpine Region (the GAR) covering the area between 4-19°E and 43-50°N and an altitude range between 0 and more than 4000 m asl. offers a challenging climate worth to be studied in any detail. However, it is surprising that up to now no comprehensive Alpine Temperature Climatology covering the whole region is existing. To overcome this deficiency as a first step we want to produce monthly temperature maps for this region in spatial resolution as high as possible. The period under investigation will be 1961-1990. In this paper we will describe the first steps of our initiative as well as the further plans

Benchmarking homogenization algorithms for monthly data

The COST (European Cooperation in Science and Technology) Action ES0601: Advances in homogenization methods of climate series: an integrated approach (HOME) has executed a blind intercomparison and validation study for monthly homogenization algorithms. Time series of monthly temperature and precipitation were evaluated because of their importance for climate studies. The algorithms were validated against a realistic benchmark dataset. Participants provided 25 separate homogenized contributions as part of the blind study as well as 22 additional solutions submitted after the details of the imposed inhomogeneities were revealed. These homogenized datasets were assessed by a number of performance metrics including i) the centered root mean square error relative to the true homogeneous values at various averaging scales, ii) the error in linear trend estimates and iii) traditional contingency skill scores. The metrics were computed both using the individual station series as well as the network average regional series. The performance of the contributions depends significantly on the error metric considered. Although relative homogenization algorithms typically improve the homogeneity of temperature data, only the best ones improve precipitation data. Moreover, state-of-the-art relative homogenization algorithms developed to work with an inhomogeneous reference are shown to perform best. The study showed that currently automatic algorithms can perform as well as manual ones

Association analysis between symptomology and herpesvirus IgG antibody concentrations in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis

Data availability statement: The data set used in this study is freely available from the United Kingdom ME/CFS biobank upon application.Supplementary data are available online at https://www.sciencedirect.com/science/article/pii/S2405844023054580?via%3Dihub#appsec2 .Copyright © 2023 The Authors. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS) are two complex and multifactorial diseases whose patients experience persistent fatigue, cognitive impairment, among other shared symptoms. The onset of these diseases has also been linked to acute herpesvirus infections or their reactivations. In this work, we re-analyzed a previously-described dataset related to IgG antibody responses to 6 herpesviruses (CMV – cytomegalovirus; EBV – Epstein-Barr virus; HHV6 – human herpesvirus-6; HSV1 and HSV2 – herpes simplex virus-1 and -2, respectively; VZV – varicella-zoster virus) from the United Kingdom ME/CFS biobank. The primary goal was to report the underlying symptomology and its association with herpesvirus IgG antibodies using data from 4 disease-trigger-based subgroups of ME/CFS patients (n = 222) and patients with MS (n = 46). The secondary objective was to assess whether serological data could distinguish ME/CFS and its subgroup from MS using a SuperLearner (SL) algorithm. There was evidence for a significant negative association between temporary eye insight disturbance and CMV antibody concentrations and for a significant positive association between bladder problems and EBV antibody concentrations in the MS group. In the ME/CFS or its subgroups, the most significant antibody-symptom association was obtained for increasing HSV1 antibody concentration and brain fog, a finding in line with a negative impact of HSV1 exposure on cognitive outcomes in both healthy and disease conditions. There was also evidence for a higher number of significant antibody-symptom associations in the MS group than in the ME/CFS group. When we combined all the serological data in an SL algorithm, we could distinguish three ME/CFS subgroups (unknown disease trigger, non-infection trigger, and an infection disease trigger confirmed in the lab at the time of the event) from the MS group. However, we could not find the same for the remaining ME/CFS group (related to an unconfirmed infection disease). In conclusion, IgG antibody data explains more the symptomology of MS patients than the one of ME/CFS patients. Given the fluctuating nature of symptoms in ME/CFS patients, the clinical implication of these findings remains to be determined with a longitudinal study. This study is likely to ascertain the robustness of the associations during natural disease course.This research was funded by: FCT - Fundação para a Ciência e Tecnologia, Portugal, ref. grant: SFRH/BD/149758/2019 (J.M.), and UIDB/00006/2020 (T.D.D., J.M., H.M., NS); the Polish National Agency for Academic Exchange (NAWA), ref. grant: PPN/ULM/2020/1/00069/U/00001 (N.S.). The UKMEB was established with a joint grant from the charities ME Association (including continuing support), ME Research UK and Action for ME, as well as private donors. Research reported in this manuscript was supported by the National Institutes of Health (NIH) under award number 2R01AI103629